Author Correction: The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel

Stephan, Gabriele; Huang, Lumei; Tang, Yong; Vilotti, Sandra; Fabbretti, Elsa; Yu, Ye; Nörenberg, Wolfgang; Franke, Heike; Gölöncsér, Flóra; Sperlágh, Beáta; Dopychai, Anke; Hausmann, Ralf; Schmalzing, Günther; Rubini, Patrizia; Illéš, Peter

doi:10.1038/s41467-018-05621-7

Cited by 5 publications

(2 citation statements)

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“…In particular, P2X receptors may physically interact with members of the Cys-loop receptor family such as nicotinic, GABA A/C , and 5-HT 3A receptors [ 46 , 47 , 48 , 49 , 50 ]. A recent study revealed that P2X3 receptors in sensory neurons tightly associate with acid-sensing ion channels, thereby forming a protein complex that mediates unidirectional inhibition [ 51 ]. Furthermore, protein modifications such as glycosylation can affect the function of ion channels at the level of subunit assembly, protein trafficking, ligand binding, and channel opening.…”

Section: Discussionmentioning

confidence: 99%

Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing

Metzner

Zhou

et al. 2021

IJMS

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The sodium-activated potassium channel Slack (KNa1.1, Slo2.2, or Kcnt1) is highly expressed in populations of sensory neurons, where it mediates the sodium-activated potassium current (IKNa) and modulates neuronal activity. Previous studies suggest that Slack is involved in the processing of neuropathic pain. However, mechanisms underlying the regulation of Slack activity in this context are poorly understood. Using whole-cell patch-clamp recordings we found that Slack-mediated IKNa in sensory neurons of mice is reduced after peripheral nerve injury, thereby contributing to neuropathic pain hypersensitivity. Interestingly, Slack is closely associated with ATP-sensitive P2X3 receptors in a population of sensory neurons. In vitro experiments revealed that Slack-mediated IKNa may be bidirectionally modulated in response to P2X3 activation. Moreover, mice lacking Slack show altered nocifensive responses to P2X3 stimulation. Our study identifies P2X3/Slack signaling as a mechanism contributing to hypersensitivity after peripheral nerve injury and proposes a potential novel strategy for treatment of neuropathic pain.

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Section: Discussionmentioning

confidence: 99%

Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing

Metzner

Zhou

et al. 2021

IJMS

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“…Homomeric P2X3 and P2X7Rs and heteromeric P2X2/3Rs (North, 2002;Wirkner et al, 2007) mediate inflammatory, neuropathic, visceral, and cancer pain (Burnstock 2013, Burnstock, 2016. Interestingly, ASIC3 and P2X3Rs appear to interact with each other in response to protons and ATP, by forming an ASIC3/P2X3 "cognate" receptor, establishing a tight relationship between acidic and purinergic mechanisms in pain induction (Stephan et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Increasing Efficiency of Repetitive Electroacupuncture on Purine- and Acid-Induced Pain During a Three-Week Treatment Schedule

Zhang

Illéš

et al. 2021

Front. Pharmacol.

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Acupuncture (AP) is an important constituent of the therapeutic repertoire of traditional Chinese medicine and has been widely used to alleviate chronic painful conditions all over the world. We studied in rats the efficiency of electroacupuncture (EAP) applied to the Zusanli acupoint (ST36) as an analgesic treatment over a 3-week period of time on purine (α,β-methylene ATP, dibenzoyl-ATP)- and acid (pH 6.0 medium)-induced pain in the rat paw. The two ATP derivatives stimulated P2X3 and P2X7 receptors, respectively, while the slightly acidic medium stimulated the “acid-sensitive ion channel 3” (ASIC3). It was found that the P2X7 receptor and ASIC-mediated pain was counteracted by EAP with greater efficiency at the end than at the beginning of the treatment schedule, while the P2X3 receptor–mediated pain was not. Our findings have important clinical and theoretical consequences, among others, because they are difficult to reconcile with the assumption that AP is primarily due to the release of peripheral and central opioid peptides causing the well-known tolerance to their effects. In consequence, AP is a convenient therapeutic instrument to treat subacute and chronic pain.

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Peripheral Mechanism of Cancer-Induced Bone Pain

Yang,

Zhang

et al. 2023

Neurosci. Bull.

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Author Correction: The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel

Abstract: The originally published version of this article contained an error in the name of the author Flóra Gölöncsér, which was incorrectly given as Flóra Göröncsér. This has now been corrected in both the PDF and HTML versions of the article.

Cited by 5 publications

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Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing

Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing

Increasing Efficiency of Repetitive Electroacupuncture on Purine- and Acid-Induced Pain During a Three-Week Treatment Schedule

Peripheral Mechanism of Cancer-Induced Bone Pain

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