Author response: Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network

Arnold, Torey R.; Shawky, Joseph H.; Stephenson, Rachel E.; Dinshaw, Kayla M; Higashi, Tomohito; Huq, Farah; Davidson, Lance A.; Miller, Ann L.

doi:10.7554/elife.39065.035

2019

DOI: 10.7554/elife.39065.035

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Author response: Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network

Torey R. Arnold

Joseph H. Shawky

Rachel E. Stephenson

et al.

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2023

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Neighbor cells restrain furrowing during epithelial cytokinesis

Landino

Misterovich

Chumki

et al. 2023

Preprint

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Cytokinesis challenges epithelial tissue homeostasis by generating forces that pull on neighboring cells via cell-cell junctions. Previous work has shown that junction reinforcement at the furrow in Xenopus laevis epithelia regulates the speed of furrowing. This suggests the cytokinetic array that drives cell division is subject to resistive forces from epithelial neighbor cells. We show here that contractility factors accumulate in neighboring cells near the furrow during cytokinesis. Additionally, increasing neighbor cell stiffness, via α-actinin overexpression, or contractility, through optogenetic Rho activation in one neighbor cell, slows or asymmetrically pauses furrowing, respectively. Notably, optogenetic stimulation of neighbor cell contractility on both sides of the furrow induces cytokinetic failure and binucleation. We conclude that forces from the cytokinetic array in the dividing cell are carefully balanced with restraining forces generated by neighbor cells, and neighbor cell mechanics regulate the speed and success of cytokinesis.

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Neighbor cells restrain furrowing during epithelial cytokinesis

Landino

Misterovich

Chumki

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

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Author response: Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network

Cited by 1 publication

References 0 publications

Neighbor cells restrain furrowing during epithelial cytokinesis

Neighbor cells restrain furrowing during epithelial cytokinesis

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