Author response: Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3

Park, Jeong Hyang; Chung, Chang Geon; Park, Sung Soon; Lee, Davin; Kim, Kyung Min; Jeong, Yeonjin; Kim, Eun Sun; Cho, Jaeho; Jeon, Yu-Mi; Shen, C-K James; Hwang, Daehee; Lee, Sung Bae

doi:10.7554/elife.60132.sa2

2020

DOI: 10.7554/elife.60132.sa2

|View full text |Cite

Author response: Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3

Jeong Hyang Park

Chang Geon Chung

Sung Soon Park

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Unraveling the impact of disrupted nucleocytoplasmic transport systems in C9orf72-associated ALS

McGoldrick,

Robertson

2023

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two adult-onset neurodegenerative diseases that are part of a common disease spectrum due to clinical, genetic, and pathological overlap. A prominent genetic factor contributing to both diseases is a hexanucleotide repeat expansion in a non-coding region of the C9orf72 gene. This mutation in C9orf72 leads to nuclear depletion and cytoplasmic aggregation of Tar DNA-RNA binding protein 43 (TDP-43). TDP-43 pathology is characteristic of the majority of ALS cases, irrespective of disease causation, and is present in ~50% of FTD cases. Defects in nucleocytoplasmic transport involving the nuclear pore complex, the Ran-GTPase cycle, and nuclear transport factors have been linked with the mislocalization of TDP-43. Here, we will explore and discuss the implications of these system abnormalities of nucleocytoplasmic transport in C9orf72-ALS/FTD, as well as in other forms of familial and sporadic ALS.

show abstract

Unraveling the impact of disrupted nucleocytoplasmic transport systems in C9orf72-associated ALS

McGoldrick,

Robertson

2023

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Author response: Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3

Cited by 1 publication

References 0 publications

Unraveling the impact of disrupted nucleocytoplasmic transport systems in C9orf72-associated ALS

Unraveling the impact of disrupted nucleocytoplasmic transport systems in C9orf72-associated ALS

Contact Info

Product

Resources

About