Author response: Decoding odor quality and intensity in the Drosophila brain

Strutz, Antonia; Soelter, Jan; Baschwitz, Amelie; Farhan, Abu; Grabe, Veit; Rybak, Jürgen; Knaden, Markus; Schmuker, Michael; Hansson, Bill S.; Sachse, Silke

doi:10.7554/elife.04147.020

Cited by 4 publications

(3 citation statements)

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“…The lateral horn has been shown to mediate olfactory behaviors in a rapid, experience-independent manner and also to segregate attractive and aversive odors into anatomical subdomains of the neuropil [26,27,29,31]. Our findings support the hypothesis that the attractive olfactory pathway is specifically engaged for visual object valence reversal [27,28,32].…”

Section: Resultssupporting

confidence: 78%

Olfactory and Neuromodulatory Signals Reverse Visual Object Avoidance to Approach in Drosophila

2019

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Section: Resultssupporting

confidence: 78%

Olfactory and Neuromodulatory Signals Reverse Visual Object Avoidance to Approach in Drosophila

2019

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“…The LH can be roughly compartmentalized according to biological valence [8,[36][37][38][39]. To explore whether a similar organization exists within the PN/PN network, we applied a high-fidelity community detection algorithm [40].…”

Section: The Synaptic Organization Of Olfactory Projection Neuronsmentioning

confidence: 99%

Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain

et al. 2020

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Summary Nervous systems contain sensory neurons, local neurons, projection neurons, and motor neurons. To understand how these building blocks form whole circuits, we must distil these broad classes into neuronal cell types and describe their network connectivity. Using an electron micrograph dataset for an entire Drosophila melanogaster brain, we reconstruct the first complete inventory of olfactory projections connecting the antennal lobe, the insect analog of the mammalian olfactory bulb, to higher-order brain regions in an adult animal brain. We then connect this inventory to extant data in the literature, providing synaptic-resolution “holotypes” both for heavily investigated and previously unknown cell types. Projection neurons are approximately twice as numerous as reported by light level studies; cell types are stereotyped, but not identical, in cell and synapse numbers between brain hemispheres. The lateral horn, the insect analog of the mammalian cortical amygdala, is the main target for this olfactory information and has been shown to guide innate behavior. Here, we find new connectivity motifs, including axo-axonic connectivity between projection neurons, feedback, and lateral inhibition of these axons by a large population of neurons, and the convergence of different inputs, including non-olfactory inputs and memory-related feedback onto third-order olfactory neurons. These features are less prominent in the mushroom body calyx, the insect analog of the mammalian piriform cortex and a center for associative memory. Our work provides a complete neuroanatomical platform for future studies of the adult Drosophila olfactory system.

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“…These possibilities could be tested using a discrimination task across a number of odorants followed by a recall test to similar and dissimilar odorants, as done in Guerrieri et al (2005). Coding of complex olfactory mixtures is not well studied in the AL, despite these stimuli being abundant in natural settings (Laloi et al, 2000;Strutz et al, 2014;Locatelli et al, 2016;Guerrieri et al, 2005;Zhou et al, 2018). More complex olfactory stimuli could be computationally more intensive to process.…”

Section: Perception Of Odors With Reduced Experiencementioning

confidence: 99%

Experience-dependent tuning of early olfactory processing in the adult honey bee,Apis mellifera

Jernigan

Halby

Gerkin

et al. 2019

Journal of Experimental Biology

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Experience-dependent plasticity in the central nervous system allows an animal to adapt its responses to stimuli over different time scales. In this study, we explored the impacts of adult foraging experience on early olfactory processing by comparing naturally foraging honey bees, Apis mellifera, with those that experienced a chronic reduction in adult foraging experience. We placed age-matched sets of sister honey bees into two different olfactory conditions, in which animals were allowed to forage ad libitum. In one condition, we restricted foraging experience by placing honey bees in a tent in which both sucrose and pollen resources were associated with a single odor. In the second condition, honey bees were allowed to forage freely and therefore encounter a diversity of naturally occurring resourceassociated olfactory experiences. We found that honey bees with restricted foraging experiences had altered antennal lobe development. We measured the glomerular responses to odors using calcium imaging in the antennal lobe, and found that natural olfactory experience also enhanced the inter-individual variation in glomerular response profiles to odors. Additionally, we found that honey bees with adult restricted foraging experience did not distinguish relevant components of an odor mixture in a behavioral assay as did their freely foraging siblings. This study highlights the impacts of individual experience on early olfactory processing at multiple levels.

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Author response: Decoding odor quality and intensity in the Drosophila brain

Cited by 4 publications

References 0 publications

Olfactory and Neuromodulatory Signals Reverse Visual Object Avoidance to Approach in Drosophila

Olfactory and Neuromodulatory Signals Reverse Visual Object Avoidance to Approach in Drosophila

Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain

Experience-dependent tuning of early olfactory processing in the adult honey bee,Apis mellifera

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