Author response: Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task

Tsutsui-Kimura, Iku; Matsumoto, Hideyuki; Akiti, Korleki; Yamada, Melissa M; Uchida, Naoshige; Watabe-Uchida, Mitsuko

doi:10.7554/elife.62390.sa2

2020

DOI: 10.7554/elife.62390.sa2

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Author response: Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task

Iku Tsutsui-Kimura

Hideyuki Matsumoto

Korleki Akiti

et al.

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Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction

Akiti

Tsutsui-Kimura

Xie

et al. 2021

Preprint

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Animals exhibit diverse behavioral responses, such as exploration and avoidance, to novel cues in the environment. However, it remains unclear how dopamine neuron-related novelty responses influence behavior. Here, we characterized dynamics of novelty exploration using multi-point tracking (DeepLabCut) and behavioral segmentation (MoSeq). Novelty elicits a characteristic sequence of behavior, starting with investigatory approach and culminating in object engagement or avoidance. Dopamine in the tail of striatum (TS) suppresses engagement, and dopamine responses were predictive of individual variability in behavior. Behavioral dynamics and individual variability were explained by a novel reinforcement learning (RL) model of threat prediction, in which behavior arises from a novelty-induced initial threat prediction (akin to shaping bonus), and a threat prediction that is learned through dopamine-mediated threat prediction errors. These results uncover an algorithmic similarity between reward- and threat-related dopamine sub-systems.

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Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction

Akiti

Tsutsui-Kimura

Xie

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

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Author response: Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task

Cited by 1 publication

References 0 publications

Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction

Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction

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