Author response: Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

Peer Review #1 of "Temporal expression profiles of lncRNA and mRNA in human embryonic stem cell-derived motor neurons during differentiation (v0.1)"

“…LncRNA Haunt functions as a genetic enhancer and an epigenetic repressor of HOXA gene activation during ESC differentiation [12]. Dlk1-Dio3 locus-derived lncRNAs play a critical role in maintaining postmitotic MN cell fate by repressing progenitor genes and they shape MN subtype identity by regulating Hox genes [13]. Nevertheless, at present very little functional characterization of lncRNAs in human motor neuron differentiation has been elucidated.…”