Author response: Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis

Martínez‐Abadías, Neus; Estivill, Roger Mateu; Tomas, Jaume Sastre; Perrine, Susan M. Motch; Yoon, Melissa; Robert‐Moreno, Alexandre; Swoger, Jim; Russo, Lucía; Kawasaki, Kazuhiko; Richtsmeier, Joan T.; Sharpe, James

doi:10.7554/elife.36405.032

2018

DOI: 10.7554/elife.36405.032

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Author response: Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis

Neus Martínez‐Abadías

Roger Mateu Estivill

Jaume Sastre Tomas

et al.

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It’s about Time: Ossification Center Formation in C57BL/6 Mice from E12–E16

Flaherty

Richtsmeier

2018

JDB

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The establishment of precise, high-resolution temporal sequences for morphogenetic events in laboratory mice remains a vexing issue in developmental biology. Mouse embryos collected at the same period of gestation, even those from the same litter, show wide variation in individual levels of progress along their developmental trajectory. Therefore, age at harvest does not provide sufficient information about developmental progress to serve as the basis for forming samples for the study of rapidly or near-simultaneously occurring events such as the sequence of ossification center formation. Here, we generate two measures of individual developmental progress (developmental age) for a large sample of mouse embryos using crown–rump lengths that measures size, and limbstaging ages produced by the embryonic Mouse Ontogenetic Staging System (eMOSS) that measure shape. Using these measures, we establish fine-grained sequences of ossification center appearance for mouse embryos. The two measures of developmental progress generate slightly different sequences of ossification center formation demonstrating that despite their tight correlation throughout the developmental period, size and shape are aspects of form that are at least partially dissociated in development.

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It’s about Time: Ossification Center Formation in C57BL/6 Mice from E12–E16

Flaherty

Richtsmeier

2018

JDB

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Author response: Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis

Cited by 1 publication

References 0 publications

It’s about Time: Ossification Center Formation in C57BL/6 Mice from E12–E16

It’s about Time: Ossification Center Formation in C57BL/6 Mice from E12–E16

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