Author Response: Retinal Phenotypes in Patients Homozygous for the G1961E Mutation in the<i>ABCA4</i>Gene

Burke, Tomas R.; Allikmets, Rando

doi:10.1167/iovs.12-11528

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…Recent studies have challenged the long-standing perception that hemoglobin is specifically expressed in erythrocytes [6,7]. These studies have revealed hemoglobin expression in non-erythrocytes, including neurons, retinal cells, alveolar cells, mesangial cells of the kidney, and macrophages [10,11,13,16,26]. In the present study, we performed immunoblotting analysis to investigate the expression of HBQ1 in lung adenocarcinoma cell lines A549 and A427.…”

Section: Discussionmentioning

confidence: 88%

“…Its primary function is to transport oxygen from the lungs to various tissues in the body [8,9]. However, recent studies have revealed that hemoglobin is also expressed in non-erythroid cells, such as neurons [10][11][12], retinal cells [13][14][15], alveolar epithelial cells [16][17][18], endometrium [19,20], kidney mesangial cells [21,22], hepatocytes [23,24], and macrophages [25,26]. Furthermore, hemoglobin is differentially expressed in solid tumors, including breast, ovarian, and colorectal cancer [27][28][29].…”

Section: Of 10mentioning

confidence: 99%

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Hemoglobin Subunit Theta 1 Promotes Proliferation by Reducing Reactive Oxygen Species in Lung Adenocarcinoma

Kim,

Choi,

Ahn

et al. 2023

Cancers

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Lung adenocarcinoma is a crucial contributor to cancer-related mortality; however, effective treatments remain challenging. The present study aimed to investigate the role of hemoglobin subunit theta 1 (HBQ1), an α subunit of hemoglobin whose expression has recently been reported in non-erythroid cells, in lung adenocarcinoma. Comparative analysis showed that HBQ1 expression was significantly higher in lung adenocarcinoma tissues compared to normal lung tissues. Moreover, high HBQ1 expression was correlated with unfavorable overall survival and progression-free survival in patients, highlighting its potential as a prognostic marker. Our functional experiments revealed that when overexpressed, HBQ1 acts as an oncogene, enhancing cell proliferation, whereas HBQ1 knockdown inhibits it. Additionally, HBQ1 exhibited antioxidant properties by reducing basal reactive oxygen species levels, playing a crucial role in lung adenocarcinoma progression. These findings emphasize the critical role of HBQ1 in driving tumor growth and progression in lung adenocarcinoma. Our in vivo studies further supported the role of HBQ1 in lung adenocarcinoma. HBQ1 knockdown resulted in the inhibition of lung adenocarcinoma growth, demonstrating the potential of HBQ1 as a therapeutic target. Our findings highlight the importance of HBQ1 in lung adenocarcinoma and suggest its potential as both a diagnostic marker and a molecular target for therapeutic interventions.

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Section: Discussionmentioning

confidence: 88%

Section: Of 10mentioning

confidence: 99%

Hemoglobin Subunit Theta 1 Promotes Proliferation by Reducing Reactive Oxygen Species in Lung Adenocarcinoma

Kim,

Choi,

Ahn

et al. 2023

Cancers

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“…The significance of HS and its prognostic implications for ocular symptoms have not yet been determined. Studies on animal models show that intravitreal haemoglobin can cause retinal pigmented epithelial cell and glial cell proliferation and, hence, vitreous haemorrhage can aggravate the progression of certain non‐vascular proliferative retinopathies 12,13 . Further studies are required to determine how this translates to human ocular tissues in vivo.…”

Section: Discussionmentioning

confidence: 99%

Haemoglobin spherulosis: Fine needle aspiration biopsy of an unusual ocular lesion

Challa

Wakely

2023

Cytopathology

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Objective Haemoglobin spherulosis (HS) is a rare lesion occurring post‐vitreous haemorrhage that is absent from the cytopathology literature. Methods We present the fine needle aspiration (FNA) biopsy cytological features of a case of HS occurring in a 73‐year‐old woman. Results FNA smears of hemorrhagic vitreous fluid showed numerous variably sized smooth glassy spherules ranging from 3‐20 μm. Occasional red cells and a rare lymphocyte were observed, but other cell types were absent. Immunohistochemical staining of a cell block showed diffuse positive staining of spherules with haemoglobin A. Conclusions HS is a rare lesion that occurs post‐subretinal haemorrhage and may be encountered by pathologists examining ocular cytological specimens.

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Author Response: Retinal Phenotypes in Patients Homozygous for the G1961E Mutation in theABCA4Gene

Cited by 2 publications

References 5 publications

Hemoglobin Subunit Theta 1 Promotes Proliferation by Reducing Reactive Oxygen Species in Lung Adenocarcinoma

Hemoglobin Subunit Theta 1 Promotes Proliferation by Reducing Reactive Oxygen Species in Lung Adenocarcinoma

Haemoglobin spherulosis: Fine needle aspiration biopsy of an unusual ocular lesion

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