Author response: Structural basis of malodour precursor transport in the human axilla

Minhas, G.S.; Bawdon, Daniel; Herman, Reyme; Rudden, Michelle; Stone, Abraham; James, A. Gordon; Thomas, Gavin H.; Newstead, Simon

doi:10.7554/elife.34995.028

Cited by 3 publications

(2 citation statements)

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“…Bacteria on the skin can take up the conjugate by active transport. This has been demonstrated for an isolate of S. hominis, and the uptake protein was characterized at the molecular level based on the crystal structure [29]. For Corynebacteria, the transport protein was not investigated, but we could show that the enzymes for the cleavage of the conjugate reside inside the cells [30] and hence active uptake is required, too.…”

Section: The Biochemical Steps For Odour Releasesulfur Compoundsmentioning

confidence: 96%

The specific biochemistry of human axilla odour formation viewed in an evolutionary context

Natsch

Emter

2020

Phil. Trans. R. Soc. B

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Human body odour is dominated by the scent of specific odourants emanating from specialized glands in the axillary region. These specific odourants are produced by an intricate interplay between biochemical pathways in the host and odour-releasing enzymes present in commensal microorganisms of the axillary microbiome. Key biochemical steps for the release of highly odouriferous carboxylic acids and sulfur compounds have been elucidated over the past 15 years. Based on the profound molecular understanding and specific analytical methods developed, evolutionary questions could be asked for the first time with small population studies: (i) a genetic basis for body odour could be shown with a twin study, (ii) no effect of genes in the human leukocyte antigen complex on the pattern of odourant carboxylic acid was found, and (iii) loss of odour precursor secretion by a mutation in the ABCC11 gene could explain why a large fraction of the population in the Far East lack body odour formation. This review summarizes what is currently known at the molecular level on the biochemistry of the formation of key odourants in the human axilla. At the same time, we present for the first time the crystal structure of the N α -acyl-aminoacylase, a key human odour-releasing enzyme, thus describing at the molecular level how bacteria on the skin surface have adapted their enzyme to the specific substrates secreted by the human host. This article is part of the Theo Murphy meeting issue ‘Olfactory communication in humans’.

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Section: The Biochemical Steps For Odour Releasesulfur Compoundsmentioning

confidence: 96%

The specific biochemistry of human axilla odour formation viewed in an evolutionary context

Natsch

Emter

2020

Phil. Trans. R. Soc. B

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“…The Bollywood stars experienced preferential treatment by the organisers. 73 Likewise, Modi's government started ‗Project Mausam' to highlight the country's historic maritime trade and civilisational links with the Gulf countries. 74 Through this project, Indian Ministry of Culture is organising cultural events in the GCC states on a regular basis.…”

Section: India's Soft Image In the Gulfmentioning

confidence: 99%

India’s Growing Influence in the Gulf States: Political, Strategic and Economic Risks for Pakistan

Abbas¹

2019

iprij

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The paper explores India's growing role in the Gulf Cooperation Council (GCC), the primary drivers behind its success in fostering a strong economic and strategic relationship with Council members, and its implications for Pakistan. The study observes that Pakistan's policy of neutrality in Yemen's conflict, Saudi-Qatar impasse, and support of Iran's nuclear deal may have pushed the GCC states closer to India over the past few years. It also finds that unlike their economic relationship, security cooperation between India and the Gulf region is still limited in scope, but enhancing gradually. If India's political and security interaction further expands, it could deprive Pakistan of strong political and economic partners in the region which is New Delhi's ultimate strategic objective.

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Molecular Modeling and <i>In Vitro</i> Study of Malodor Inhibition Using Thai Herbal Products

Namwong

Peungsamran

2020

KEM

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Eighty-one microbial odors were isolated and identified based on phenotypic characterization and 16S rRNA gene sequence similarity. The dominant microbial odors (Group C, 27 isolates) were classified as Staphylococcus hominis subsp. hominis DSM 20328T. The genome annotation of all representative microbial odors revealed that they consisted of malodor biosynthesis pathways; short-chain volatile fatty acids (VFAs) and thioalcohol (3-methyl-3-sulfanyl-hexan-1-ol, 3M3SH). Among them, 3M3SH was the most important malodor compound and its key enzyme was cystathionine beta-lyase. To screen the cystathionine beta-lyase inhibitors by docking with PyRx, three bioactive compounds from natural products [gallic acid (CID 370), 1-heneicosanol (CID 85014) and 2,6-dimethylheptadecane (CID 545603)] were predicted to be effective in binding with the target enzyme close to the synthetic inhibitor [N-(2-Hydrazinyl-2-oxoethyl)-3-(trifluoromethyl)benzamide (CID 16109340)]. The water extract of Terminalia catappa L. revealed the highest inhibitory effect against the growth of all microbial odor isolates. Hence, our study concludes that the bioactive compounds of T. catappa L. may be used as an appropriate natural source to develop the natural sport deodorant spray in the future.

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Author response: Structural basis of malodour precursor transport in the human axilla

Cited by 3 publications

References 0 publications

The specific biochemistry of human axilla odour formation viewed in an evolutionary context

The specific biochemistry of human axilla odour formation viewed in an evolutionary context

India’s Growing Influence in the Gulf States: Political, Strategic and Economic Risks for Pakistan

Molecular Modeling and <i>In Vitro</i> Study of Malodor Inhibition Using Thai Herbal Products

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