Author response: Sustained NPY signaling enables AgRP neurons to drive feeding

Chen, Yiming; Essner, Rachel; Kosar, Seher; Miller, Oliver H.; Lin, Yen‐Chu; Mesgarzadeh, Sheyda; Knight, Zachary A.

doi:10.7554/elife.46348.013

Cited by 5 publications

(1 citation statement)

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“…To tie these results to the prevailing mechanistic understanding of ARC AGRP neuronal activity, previous studies suggest that during physiological hunger, ARC AGRP neurons are highly active and release neurotransmitters such as GABA, AGRP, and neuropeptide Y (NPY) to downstream brain regions such as the paraventricular hypothalamus (PVH). 84 Once this happens, food seeking and intake occur even in the absence of concurrent AR-C AGRP neuronal activity, 8,84 suggesting that these effects are long-lasting and dependent on brain regions and neuronal circuits outside the ARC. When a mouse detects and/or consumes a food source, ARC AGRP neuronal activity drops proportionately to the perceived and actual energy content of the food, such that more caloric foods induce larger and longer-lasting inhibition of AGRP neuronal activity.…”

Section: Articlementioning

confidence: 99%

Hypothalamic control of interoceptive hunger

et al. 2021

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Section: Articlementioning

confidence: 99%

Hypothalamic control of interoceptive hunger

et al. 2021

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Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling inC. elegans

Cermak

Clark

et al. 2020

Preprint

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Animal behaviors are commonly organized into long-lasting states that coordinately impact the generation of diverse motor outputs such as feeding, locomotion, and grooming. However, the neural mechanisms that coordinate these diverse motor programs remain poorly understood. Here, we examine how the distinct motor programs of the nematode C. elegans are coupled together across behavioral states. We describe a new imaging platform that permits automated, simultaneous quantification of each of the main C. elegans motor programs over hours or days. Analysis of these wholeorganism behavioral profiles shows that the motor programs coordinately change as animals switch behavioral states. Utilizing genetics, optogenetics, and calcium imaging, we identify a new role for dopamine in coupling locomotion and egg-laying together across states. These results provide new insights into how the diverse motor programs throughout an organism are coordinated and suggest that neuromodulators like dopamine can couple motor circuits together in a state-dependent manner.

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Neuromodulation Exerts Feedback and Feedforward Control of Action Selection

Diao¹,

Peabody²,

White³

2020

Preprint

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To be effective, behavioral choices must result in actions that are appropriate to an animal's needs and environmental circumstances. In addition, the actions must be ones the animal can sustain until its needs are met. This aligning of goals, action, and motivation requires the coordinated activity of multiple brain circuits, but how such coordination is achieved is poorly understood. Here, we show how the insect hormone Bursicon coordinates the selection and sustains execution of a behavior in newly emerged adult Drosophila. Such flies must expand and harden their wings after metamorphosis, but they choose to delay expansion in confined conditions. We show that the decision to expand is mediated by an environmentally-sensitive, positive feedback loop in which Bursicon promotes its own sustained release. Released Bursicon then modulates motor neurons to promote wing expansion behavior. Bursicon thus exerts feedforward and feedback control to coordinately select and motivate a goal-directed action.

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Author response: Sustained NPY signaling enables AgRP neurons to drive feeding

Cited by 5 publications

References 0 publications

Hypothalamic control of interoceptive hunger

Hypothalamic control of interoceptive hunger

Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling inC. elegans

Neuromodulation Exerts Feedback and Feedforward Control of Action Selection

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