Author response: The molecular architecture of engulfment during Bacillus subtilis sporulation

Khanna, K. N.; López‐Garrido, Javier; Zhao, Ziyi; Watanabe, Reika; Yuan, Yuan; Sugie, Joseph; Pogliano, Kit; Villa, Elizabeth

doi:10.7554/elife.45257.045

Cited by 2 publications

(1 citation statement)

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“…While spoIIIE is among the best characterized spo loci, the field has made significant progress in the understanding of a myriad of dynamic processes associated with sporulation, such as the formation of the polar septum [129][130][131], the migration of the mother-cell membrane around the forespore during engulfment [132][133][134][135][136][137][138][139], the synthesis of the peptidoglycan cortex [140], and the assembly of the proteinaceous coat [20,141], to name a few.…”

Section: The Genetic Basis Of Cellular Dynamicsmentioning

confidence: 99%

Milestones in Bacillus subtilis sporulation research

Riley¹,

Schwarz²,

Derman³

et al. 2021

Microb Cell

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Endospore formation has been a rich field of research for more than a century, and has benefited from the powerful genetic tools available in Bacillus subtilis. In this review, we highlight foundational discoveries that shaped the sporulation field, from its origins to the present day, tracing a chronology that spans more than one hundred eighty years. We detail how cell-specific gene expression has been harnessed to investigate the existence and function of intercellular proteinaceous channels in sporulating cells, and we illustrate the rapid progress in our understanding of the cell biology of sporulation in recent years using the process of chromosome translocation as a storyline. Finally, we sketch general aspects of sporulation that remain largely unexplored, and that we envision will be fruitful areas of future research.

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Section: The Genetic Basis Of Cellular Dynamicsmentioning

confidence: 99%

Milestones in Bacillus subtilis sporulation research

Riley¹,

Schwarz²,

Derman³

et al. 2021

Microb Cell

Self Cite

View full text Add to dashboard Cite

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Ultrastructure of exospore formation inStreptomycesrevealed by cryo-electron tomography

Sexton

Tocheva

2020

Preprint

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AbstractMany bacteria form spores in response to adverse environmental conditions. Several sporulation pathways have evolved independently and occur through distinctive mechanisms. Here, using cryo-electron tomography (cryo-ET), we examine all stages of growth and exospore formation in the model organism Streptomyces albus. Our data reveal the native ultrastructure of vegetative hyphae, including the polarisome and filaments of ParA or FilP. In addition, we observed septal junctions in vegetative septa, likely involved in effector translocation between neighbouring cells. During sporulation, the cell envelope undergoes dramatic remodeling, including the formation of a spore cortex and two protective proteinaceous layers. Mature spores reveal the presence of a continuous spore coat and an irregular rodlet sheet. Together, these results provide an unprecedented examination of the ultrastructure in Streptomyces and further our understanding of the structural complexity of exospore formation.

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Author response: The molecular architecture of engulfment during Bacillus subtilis sporulation

Cited by 2 publications

References 0 publications

Milestones in Bacillus subtilis sporulation research

Milestones in Bacillus subtilis sporulation research

Ultrastructure of exospore formation inStreptomycesrevealed by cryo-electron tomography

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