Authors’ reply re: Effect of <scp>QU</scp>i<scp>PP</scp> prediction algorithm on treatment decisions in women with a previous preterm birth: a prospective cohort study

Goodfellow, Laura; Alfirević, Z̄arko

doi:10.1111/1471-0528.15944

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…For the A-STIPP cohort, the prevalence (0.18) was derived from the QUIPP study. [26][27][28] The standard level of variance (0.15) was used to calculate the sample size.…”

Section: Power Analysismentioning

confidence: 99%

Assessment of cervical softening and the prediction of preterm birth (STIPP): protocol for a prospective cohort study

Breuking,

Oudijk,

van Eekelen

et al. 2023

BMJ Open

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IntroductionPreterm birth (PTB) is among the leading causes of perinatal and childhood morbidity and mortality. Therefore, accurate identification of pregnant women at high risk of PTB is key to enable obstetric healthcare professionals to apply interventions that improve perinatal and childhood outcomes. Serial transvaginal cervical length measurement is used to screen asymptomatic pregnant women with a history of PTB and identify those at high risk for a recurrent PTB. Cervical length measurement, fetal fibronectin test or a combination of both can be used to identify women at high risk of PTB presenting with symptoms of threatened PTB. The predictive capacity of these methods can be improved. Cervical softening is a precursor of cervical shortening, effacement and dilatation and could be a new marker to identify women a high risk of PTB. However, the predictive value of cervical softening to predict spontaneous PTB still needs to be determined.Methods and analysisThis is a single-centre, prospective cohort study, conducted at the Amsterdam University Medical Centers in the Netherlands. Cervical softening will be investigated with a non-invasive CE-marked device called the Pregnolia System. This device has been developed to evaluate consistency of the cervix based on tissue elasticity. Two different cohorts will be investigated. The first cohort includes women with a history of spontaneous PTB <34 weeks. These women undergo biweekly measurements between 14 and 24 weeks of gestation. The second cohort includes women with symptoms of threatened PTB. These women will receive the measurement once at presentation between 24 and 34 weeks of gestation. The primary outcome is spontaneous PTB before 34 weeks for women with a history of PTB and delivery within 7 days for women with threatened PTB. The minimum sample size required to analyse the primary outcome is 227 women in the cohort of women with a history of PTB and 163 women in the cohort of women with symptoms of threatened PTB. Once this number is achieved, the study will be continued to investigate secondary objectives.Ethics and disseminationThe study is approved by the Medical Ethics Committee of Amsterdam UMC (METC2022.0226). All patients will give oral and written informed consent prior to study entry. Results will be disseminated via a peer-reviewed journal.Trial registration numberNCT05477381.

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“…For the A-STIPP cohort, the prevalence (0.18) was derived from the QUIPP study. [26][27][28] The standard level of variance (0.15) was used to calculate the sample size.…”

Section: Power Analysismentioning

confidence: 99%

Assessment of cervical softening and the prediction of preterm birth (STIPP): protocol for a prospective cohort study

Breuking,

Oudijk,

van Eekelen

et al. 2023

BMJ Open

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“…Similarly, the QUiPP app v.2 algorithms developed and validated for the prediction of PTB in women with symptoms of threatened PTL demonstrated good accuracy, with AUCs of 0.96 for PTB < 30 weeks, 0.85 for PTB < 34 weeks, 0.77 for PTB < 37 weeks, 0.91 for PTB < 1 week from testing and 0.92 for PTB < 2 weeks from testing 183 . Of note, there has been some discussion about risk thresholds for spontaneous PTB to be used for individualized risk assessment/shared decision-making in women with a previous PTB and the applicability of the QUiPP app for small samples from tertiary centers [184][185][186] , which should stimulate further studies addressing this tool's performance. The 'Evaluation of the QUiPP app for Triage and Transfer' (EQUIPTT) multicenter cluster RCT studied the use of the QUiPP app to triage women with symptoms of PTL vs the unit's conventional management 187 .…”

Section: Recent Advances and New Perspectivesmentioning

confidence: 99%

ISUOGPractice Guidelines: role of ultrasound in the prediction of spontaneous preterm birth

Coutinho

Sotiriadis

Odibo

et al. 2022

Ultrasound in Obstet & Gyne

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and Gynecology (ISUOG) is a scientific organization that encourages sound clinical practice and high-quality teaching and research related to diagnostic imaging in women's healthcare. The ISUOG Clinical Standards Committee (CSC) has a remit to develop Practice Guidelines and Consensus Statements as educational recommendations that provide healthcare practitioners with a consensus-based approach, from experts, for diagnostic imaging. They are intended to reflect what is considered by ISUOG to be the best practice at the time at which they are issued. Although ISUOG has made every effort to ensure that Guidelines are accurate when issued, neither the Society nor any of its employees or members accepts liability for the consequences of any inaccurate or misleading data, opinions or statements issued by the CSC. The ISUOG CSC documents are not intended to establish a legal standard of care, because interpretation of the evidence that underpins the Guidelines may be influenced by individual circumstances, local protocol and available resources. Approved Guidelines can be distributed freely with the permission of ISUOG (

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Authors’ reply re: Effect of QUiPP prediction algorithm on treatment decisions in women with a previous preterm birth: a prospective cohort study

Cited by 2 publications

References 2 publications

Assessment of cervical softening and the prediction of preterm birth (STIPP): protocol for a prospective cohort study

Assessment of cervical softening and the prediction of preterm birth (STIPP): protocol for a prospective cohort study

ISUOGPractice Guidelines: role of ultrasound in the prediction of spontaneous preterm birth

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