Authors' response: generic medications in ophthalmology

Connor, Alan; Fraser, Scott

doi:10.1136/bjophthalmol-2013-303159

Cited by 4 publications

(3 citation statements)

References 4 publications

(4 reference statements)

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“…3 Experimental studies showed that higher doses of NO induce apoptotic cell death in photoreceptors. 4 Our electrophysiological data suggest that retinal toxicity of poppers is not restricted to central cone photoreceptors only, as suggested by previous reports, but that damage may well extend peripherally also affecting rod photoreceptors. It remains elusive whether the degree of retinal damage and the involvement of rods depend on the highest level of local NO concentration or on frequency, subtype, or amount of poppers intake.…”

supporting

confidence: 87%

“…There was a small crossover study by Gandolfi and Cimino, 2 which showed IOP-lowering effect in 13 out of 15 latanoprost nonresponders who switched to bimatoprost. There have also been small studies 3,4 and anecdotal reports 5 regarding issues with generic latanoprost bottles due to the different manufacturers. These reasons may account for the move away from generic latanoprost to bimatoprost.…”

mentioning

confidence: 99%

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Reply to: ‘Glaucoma prescribing trends in England 2000 to 2012’

Tiew

Choudhary

2014

Eye

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supporting

confidence: 87%

mentioning

confidence: 99%

Reply to: ‘Glaucoma prescribing trends in England 2000 to 2012’

Tiew

Choudhary

2014

Eye

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“…Therefore, the compliance of many patients decreases when shifting to the generic drug. In direct contrast to this, compliance and adherence may paradoxically increase, especially in poor patients who cannot afford costly medications [25,26].…”

Section: Fixed Drug Combinations (Fdcs)mentioning

confidence: 98%

Generics versus brand-named drugs for glaucoma: the debate continues

Bhartiya¹,

Dhingra²

2020

rjo

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There are three options for a given class of drugs, including brand name drugs, generic and branded generic drugs. Brand name drugs are costlier as compared to generic and branded generic drugs because they are innovator molecules developed by a company after many years of research and come into the market with a patent, whereas branded generic drugs are produced by a different company once the patent of innovator company expires. Given that glaucoma is a chronic, largely asymptomatic disease, the choice of drugs is extremely important: the duration of medication is often lifelong, and the cost of drugs, side effects and efficacy affect compliance and adherence to therapy. This review is a brief overview of the available brand name and branded generic drugs for the management of glaucoma, in terms of efficacy and side effect profiles. It also aimed to guide rational and pragmatic drug choices in different clinical scenarios.

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