Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association

Taylor, Brent; Miller, Elizabeth; Farrington, Paddy; Petropoulos, Maria-Christina; Favot-Mayaud, Isabelle; Li, Jun; Waight, Pauline

doi:10.1016/s0140-6736(99)01239-8

Cited by 640 publications

(208 citation statements)

References 18 publications

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“…77 Epidemiological and case-control studies did not show an increased risk by the vaccination. [78][79][80][81] Therefore, the MMR vaccination currently cannot be regarded as a risk factor for the development of AD.…”

Section: Associated Non-genetic Medical or Environmental Conditionsmentioning

confidence: 99%

The genetics of autistic disorders and its clinical relevance: a review of the literature

2006

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Twin and family studies in autistic disorders (AD) have elucidated a high heritability of the narrow and broad phenotype of AD. In this review on the genetics of AD, we will initially delineate the phenotype of AD and discuss aspects of differential diagnosis, which are particularly relevant with regard to the genetics of autism. Cytogenetic and molecular genetic studies will be presented in detail, and the possibly involved aetiopathological pathways will be described. Implications of the different genetic findings for genetic counselling will be mentioned.

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Section: Associated Non-genetic Medical or Environmental Conditionsmentioning

confidence: 99%

The genetics of autistic disorders and its clinical relevance: a review of the literature

2006

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“…Arguably, their views gained credence from clinical studies (Wakefield et al, 1998;Uhlmann et al, 2002). Subsequent studies considering the incidence of autism in relation to MMR among larger populations claim not to show an association (e.g., Taylor et al, 1999;DeWilde, Carey, Richards, Hilton, & Cook, 2001;Fombonne, 2001;see Miller, 2002, andJefferson, Price, Demicheli, &Bianco, 2003, for reviews). The debate turns, in part, on the significance attributed to epidemiological as opposed to clinical evidence, and on the status attributed to parents' own observations.…”

Section: Introductionmentioning

confidence: 99%

‘MMR talk’ and vaccination choices: An ethnographic study in Brighton

Poltorak

Leach

Fairhead

et al. 2005

Social Science & Medicine

164

136

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In the context of the high-profile controversy that has unfolded in the UK around the measles, mumps and rubella (MMR) vaccine and its possible adverse effects, this paper explores how parents in Brighton, southern England, are thinking about MMR for their own children. Research focusing on parents' engagement with MMR has been dominated by analysis of the proximate influences on their choices, and in particular scientific and media information, which have led health policy to focus on information and education campaigns. This paper reports ethnographic work including narratives by mothers in Brighton. Our work questions such reasoning in showing how wider personal and social issues shape parents' immunisation actions. The narratives by mothers show how practices around MMR are shaped by personal histories, by birth experiences and related feelings of control, by family health histories, by their readings of their child's health and particular strengths and vulnerabilities, by particular engagements with health services, by processes building or undermining confidence, and by friendships and conversations with others, which are themselves shaped by wider social differences and transformations. Although many see vaccination as a personal decision which must respond to the particularities of a child's immune system, 'MMR talk', which affirms these conceptualisations, has become a social phenomenon in itself. These perspectives suggest ways in which people's engagements with MMR reflect wider changes in their relations with science and the state. r

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“…Additional evidence includes primarily anecdotal reports, from parents noticing the onset of autism closely following immunization. Epidemiological evidence consistently does not support any correlation between the administration of the MMR vaccine and the incidence of autism (Chen, Landau, Sham, & Fombonne, 2004;Fombonne & Chakrabarti, 2001;Kaye, del Mar Melero-Montes, & Jick, 2001;Taylor et al, 1999), suggesting that anecdotal evidence may often be due to the concordance in the age of MMR vaccination and onset of autistic symptomatology. Another related theory is autism induced by neurotoxic levels of mercury, or from the presence of ethylmercury in the vaccine preservative thimerosal.…”

Section: Alternative Theoriesmentioning

confidence: 99%

A Review on the Cognitive Neuroscience of Autism

Koyama

2009

Act Nerv Super

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With increased recognition in the media, heightened prevalence, and advances in research technologies, investigation into the causes of autism has broadened in recent years. Studies at the molecular, structural, and behavioral levels have resulted in significant findings, linking autism to qualitative differences in neurological function and an alteration of early development. Familial aggregation of autism demonstrates a strong genetic factor, although genetics can not completely account for its pathogenesis. Studies show autism having one of the most complex pathologies among neurodevelopmental disorders. Future studies applying sophisticated methodologies in new areas may shed light on current mysteries surrounding the disorder.

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Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association

Abstract: Our analyses do not support a causal association between MMR vaccine and autism. If such an association occurs, it is so rare that it could not be identified in this large regional sample.

Cited by 640 publications

References 18 publications

The genetics of autistic disorders and its clinical relevance: a review of the literature

The genetics of autistic disorders and its clinical relevance: a review of the literature

‘MMR talk’ and vaccination choices: An ethnographic study in Brighton

A Review on the Cognitive Neuroscience of Autism

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