Autism in tuberous sclerosis: evoked potential evidence for a deficit in auditory sensory processing

Seri, Stefano; Cerquiglini, Antonella; Pisani, Francesco; Curatolo, Paolo

doi:10.1016/s1388-2457(99)00137-6

Cited by 111 publications

(82 citation statements)

References 29 publications

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“…Under this view, the preference for insistence to sameness and the repetitive behaviours people with ASD display are thought to relate to their hyper/hypo sensitivities to detect change. Studies in preattentional auditory novelty detection and pre-attentive neural responses (e.g., MMN) in children with ASD have provided evidence of enhanced (Ferri et al, 2003), intact (Ceponiene et al, 2003;Kamner, Verbaten, Cuperus, Camfferman, and van Engeland, 1995) and reduced (Gomot et al, 2006;Seri, Cerquiglini, Pisani, and Curatolo, 1999) frequency detection. A similar pattern of results is also evident in the findings across the studies on low-level discrimination ability in ASD.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Auditory Processing and Restricted, Repetitive Behaviors in Adults with Autism Spectrum Disorders

Kargas

López

Reddy

et al. 2014

J Autism Dev Disord

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Section: Discussionmentioning

confidence: 99%

The Relationship Between Auditory Processing and Restricted, Repetitive Behaviors in Adults with Autism Spectrum Disorders

Kargas

López

Reddy

et al. 2014

J Autism Dev Disord

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“…Evidence from cortical auditory evoked potentials in autism, especially mismatch negativity (MMN) evidence, suggests that children with autism have difficulty encoding auditory information into transient memory (Bomba and Pang 2004;Seri et al 1999;Jansson-Verkasalo et al 2003; for a review see Groen et al 2008). MMN reflects the neural processing that is required when an incoming auditory stimulus is processed against stimulus representations that are already stored in transient auditory memory.…”

Section: Discussionmentioning

confidence: 99%

Intact Spectral but Abnormal Temporal Processing of Auditory Stimuli in Autism

Groen

Orsouw

Huurne

et al. 2009

J Autism Dev Disord

106

105

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The perceptual pattern in autism has been related to either a specific localized processing deficit or a pathway-independent, complexity-specific anomaly. We examined auditory perception in autism using an auditory disembedding task that required spectral and temporal integration. 23 children with high-functioning-autism and 23 matched controls participated. Participants were presented with two-syllable words embedded in various auditory backgrounds (pink noise, moving ripple, amplitude-modulated pink noise, amplitude-modulated moving ripple) to assess speech-in-noise-reception thresholds. The gain in signal perception of pink noise with temporal dips relative to pink noise without temporal dips was smaller in children with autism (p = 0.008). Thus, the autism group was less able to integrate auditory information present in temporal dips in background sound, supporting the complexity-specific perceptual account.

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“…There was no associated task in either of these paradigms. Seri et al (1999) then studied MMN in children with Tuberous Sclerosis Complex (TSC) and found that the amplitudes were smaller in children with TSC and autism compared to children with TSC who did not have autism (the authors did not specify developmental level of non-autistic children) (Seri et al 1999). These findings support the notion that there are differences, but not necessarily impairments, in the speed and robustness of auditory sensory memory in low functioning children with autism.…”

Section: Mismatch Negativity (Mmn)mentioning

confidence: 94%

Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review

Jeste

Nelson

2008

J Autism Dev Disord

162

160

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In this paper we critically review the literature on the use of event related potentials (ERPs) to elucidate the neural sources of the core deficits in autism. We review auditory and visual ERP studies, and then review the use of ERPs in the investigation of executive function. We conclude that, in autism, impairments likely exist in both low and higher level auditory and visual processing, with prominent impairments in the processing of social stimuli. We also discuss the putative neural circuitry underlying these deficits. As we look to the future, we posit that tremendous insight can be gained by applying ERPs to the definition of endophenotypes, which, in turn, can facilitate early diagnosis and the creation of informed interventions for children with autism. KeywordsEvent related potential (ERP); Autism; Auditory processing; Visual processing Since autism was first described by Kanner over fifty years ago (Kanner 1943), the neurobiology of this disorder has become the focus of intense scientific investigation. While extensive efforts have been made in describing the behaviors that define autism, only in recent years has progress been made to elucidate the underlying neural circuitry involved in autism, through structural and, more recently, functional neuroimaging. Through these studies has come a heightened interest in aberrant neural circuitry in autism. Of the neuroimaging tools that have been used to elucidate brain circuitry, functional electrophysiology stands alone in capacity to define early (i.e. in infancy) neural markers and endophenotypes. This technique, therefore, warrants further scrutiny. Using functional electrophysiology, defined by evoked potentials and then by event related potentials (ERPs), researchers have begun to elucidate sources of the core deficits in autism

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Autism in tuberous sclerosis: evoked potential evidence for a deficit in auditory sensory processing

Cited by 111 publications

References 29 publications

The Relationship Between Auditory Processing and Restricted, Repetitive Behaviors in Adults with Autism Spectrum Disorders

The Relationship Between Auditory Processing and Restricted, Repetitive Behaviors in Adults with Autism Spectrum Disorders

Intact Spectral but Abnormal Temporal Processing of Auditory Stimuli in Autism

Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review

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