Autism spectrum disorder and air pollution: A systematic review and meta-analysis

Dutheil, Frédéric; Comptour, Aurélie; Morlon, Roxane; Mermillod, Martial; Pereira, Bruno; Baker, Julien S.; Charkhabi, Morteza; Clinchamps, Maëlys; Bourdel, Nicolas

doi:10.1016/j.envpol.2021.116856

Cited by 66 publications

(33 citation statements)

References 84 publications

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“…Even if the weight of studies requires careful thought, because some studies had several measurement interval times and training duration, sensitivity analyses based on median or last time of follow-up time demonstrated similar results. Moreover, our method had the advantage of avoiding selection bias [72]. ) Embase ('low back pain'/exp OR 'low back pain *': ti,ab,kw OR lumbago:ti,ab,kw OR 'low back ache': ti,ab,kw OR 'lower back pain *': ti,ab,kw OR 'pain, low back': ti,ab,kw OR 'low backache': ti,ab,kw OR 'back pain, low': ti,ab,kw OR 'back pain, lower': ti,ab,kw OR 'low back syndrome': ti,ab,kw OR lumbalgia:ti,ab,kw OR 'lumbar pain': ti,ab,kw OR lbp:ti,ab,kw AND ('exercise'/exp OR 'kinesiotherapy'/exp OR 'physical activity'/exp OR 'sport'/exp OR exercise *: ti,ab,kw OR 'exercise therapy': ti,ab,kw OR 'exercise movement techniques': ti,ab,kw OR 'activity physical': ti,ab,kw OR 'physical activities': ti,ab,kw OR 'physical activity': ti,ab,kw OR sports:ti,ab,kw OR sport:ti,ab,kw) AND (homes:ti,ab,kw OR home:ti,ab,kw OR housing:ti,ab,kw OR domiciliary:ti,ab,kw) Cochrane ("low back pain" OR "low back pain*" OR "lumbago" OR "low back ache" OR "lower back pain*" OR "pain, low back" OR "low backache" OR "back pain, low" OR "back pain, lower" OR "Low back syndrome" OR "Lumbalgia" OR "Lumbar pain" OR "LBP") AND ("exercise" OR "exercise therapy" OR "exercise movement techniques" OR exercise OR exercises OR "activity physical" OR "physical activities" OR "physical activity" OR "sports" OR "sport") AND (Homes OR "housing" OR Home OR domiciliary) Science-Direct "low back pain" AND "exercise" AND "home".…”

Section: Limitationsmentioning

confidence: 99%

Effect of Home Exercise Training in Patients with Nonspecific Low-Back Pain: A Systematic Review and Meta-Analysis

Quentin

Bagheri

Ugbolue

et al. 2021

IJERPH

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Background: Exercise therapy is recommended to treat non-specific low back pain (LBP). Home-based exercises are promising way to mitigate the lack of availability of exercise centers. In this paper, we conducted a systemic review and meta-analysis on the effects of home-based exercise on pain and functional limitation in LBP. Method: PubMed, Cochrane, Embase and ScienceDirect were searched until April 20th, 2021. In order to be selected, studies needed to report the pain and functional limitation of patients before and after home-based exercise or after exercise both in a center and at-home. Random-effect meta-analyses and meta-regressions were conducted. Results: We included 33 studies and 9588 patients. We found that pain intensity decreased in the exclusive home exercise group (Effect size = −0.89. 95% CI −0.99 to −0.80) and in the group which conducted exercise both at-home and at another setting (−0.73. −0.86 to −0.59). Similarly, functional limitation also decreased in both groups (−0.75. −0.91 to −0.60, and −0.70, −0.92 to −0.48, respectively). Relaxation and postural exercise seemed to be ineffective in decreasing pain intensity, whereas trunk, pelvic or leg stretching decreased pain intensity. Yoga improved functional limitation. Supervised training was the most effective method to improve pain intensity. Insufficient data precluded robust conclusions around the duration and frequency of the sessions and program. Conclusion: Home-based exercise training improved pain intensity and functional limitation parameters in LBP.

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Section: Limitationsmentioning

confidence: 99%

Effect of Home Exercise Training in Patients with Nonspecific Low-Back Pain: A Systematic Review and Meta-Analysis

Quentin

Bagheri

Ugbolue

et al. 2021

IJERPH

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“…However, previous studies conducted in Stockholm, Sweden, did not nd associations between exposure to tra c-related air pollution during pregnancy and ASD 56,57 . Reasons for this con ict could include that these studies considered PM 10 and NO X , while ours investigated PM 2.5 , which has been the pollutant with the most evidence for autism development in systematic reviews 23,24 . One register-based study also used "symptoms of neurodevelopmental disorders" as its outcome as opposed to physician-diagnosed ASD 56 .…”

Section: Discussionmentioning

confidence: 95%

“…As the sources of locally produced air pollution may vary from setting to setting and each source can have unique effects on human health, previous research has encouraged more source-apportionment studies of PM 40 . Road tra c is often one of the largest contributors to PM emissions and is predicted to increase 24 , thus, exploring the various sources of tra c-related PM can provide a better understanding of their individual impacts on public health. Additionally, too few epidemiological studies investigating the association between ambient wood smoke from residential wood combustion and health exist to date 41 , and none consider ASD.…”

Section: Introductionmentioning

confidence: 99%

“…A 2019 systematic review and meta-analysis including both adults and children has demonstrated clearer associations, naming ASD among other neurological and developmental disorders associated with PM 2.5 exposure 22 . Two, more current, systematic reviews and meta-analyses focusing on children only and prenatal exposure speci cally identi ed the strongest evidence for PM 2.5 exposure and ASD 23,24 , with one reporting each 5 µg/m 3 incremental increase in PM 2.5 leading to a 5%, 7%, or 15% increased risk of ASD in newborns depending on the model used 24 . Prenatal exposure to nitrogen oxides (NO X ), mainly from tra c, has also been associated with an increased risk of ASD among children in a low-exposure setting 25 .…”

Section: Introductionmentioning

confidence: 99%

“…Although air pollution has been demonstrated to signi cantly affect neurodevelopment and contribute to ASD according to the latest systematic reviews and meta-analyses 23,24 , no study could be identi ed considering these associations with respect to source-speci c exposure. As the sources of locally produced air pollution may vary from setting to setting and each source can have unique effects on human health, previous research has encouraged more source-apportionment studies of PM 40 .…”

Section: Introductionmentioning

confidence: 99%

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Maternal Exposure to Local, Source-specific Ambient Air Pollution During Pregnancy and Autism in Children: a Cohort Study From Southern Sweden

Flanagan

Malmqvist

Rittner

et al. 2021

Preprint

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Evidence of air pollution exposure, namely, ambient particulate matter (PM), during pregnancy and an increased risk of autism spectrum disorders (ASD) in children is growing. Which PM sources contribute to this association is currently unknown, however. The aim of the present study was to investigate local source-specific ambient PM exposure and its association with ASD. A cohort of 48,571 singleton births from 1999 to 2009 in Scania, Sweden, was combined with data on locally emitted PM with an aerodynamic diameter <2.5 µm (PM2.5). A flat, two-dimensional dispersion model was used to model PM2.5 exposure (all-source PM2.5, tailpipe exhaust, vehicle wear-and-tear, and small-scale residential heating- mainly wood burning) at the residential address. Associations were analyzed using binary logistic regression in partially and fully adjusted models. Clear associations were observed between PM2.5 and ASD, with statistical significance for all investigated sources in the partially adjusted model. In the fully adjusted model, only all-source PM2.5 was statistically significant. The results add to existing evidence that exposure to air pollution during pregnancy may be associated with an increased risk for ASD among children. Further, these findings suggest that locally emitted tailpipe exhaust, vehicle wear-and-tear, and small-scale residential heating all contribute to this association.

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The social determinants of mental health and disorder: evidence, prevention and recommendations

Kirkbride,

Anglin,

Colman

et al. 2024

World Psychiatry

134

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People exposed to more unfavourable social circumstances are more vulnerable to poor mental health over their life course, in ways that are often determined by structural factors which generate and perpetuate intergenerational cycles of disadvantage and poor health. Addressing these challenges is an imperative matter of social justice. In this paper we provide a roadmap to address the social determinants that cause mental ill health. Relying as far as possible on high‐quality evidence, we first map out the literature that supports a causal link between social determinants and later mental health outcomes. Given the breadth of this topic, we focus on the most pervasive social determinants across the life course, and those that are common across major mental disorders. We draw primarily on the available evidence from the Global North, acknowledging that other global contexts will face both similar and unique sets of social determinants that will require equitable attention. Much of our evidence focuses on mental health in groups who are marginalized, and thus often exposed to a multitude of intersecting social risk factors. These groups include refugees, asylum seekers and displaced persons, as well as ethnoracial minoritized groups; lesbian, gay, bisexual, transgender and queer (LGBTQ+) groups; and those living in poverty. We then introduce a preventive framework for conceptualizing the link between social determinants and mental health and disorder, which can guide much needed primary prevention strategies capable of reducing inequalities and improving population mental health. Following this, we provide a review of the evidence concerning candidate preventive strategies to intervene on social determinants of mental health. These interventions fall broadly within the scope of universal, selected and indicated primary prevention strategies, but we also briefly review important secondary and tertiary strategies to promote recovery in those with existing mental disorders. Finally, we provide seven key recommendations, framed around social justice, which constitute a roadmap for action in research, policy and public health. Adoption of these recommendations would provide an opportunity to advance efforts to intervene on modifiable social determinants that affect population mental health.

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Autism spectrum disorder and air pollution: A systematic review and meta-analysis

Cited by 66 publications

References 84 publications

Effect of Home Exercise Training in Patients with Nonspecific Low-Back Pain: A Systematic Review and Meta-Analysis

Effect of Home Exercise Training in Patients with Nonspecific Low-Back Pain: A Systematic Review and Meta-Analysis

Maternal Exposure to Local, Source-specific Ambient Air Pollution During Pregnancy and Autism in Children: a Cohort Study From Southern Sweden

The social determinants of mental health and disorder: evidence, prevention and recommendations

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