Autism Spectrum Disorder and Amplified Pain

Clarke, Ciaran

doi:10.1155/2015/930874

Cited by 39 publications

(47 citation statements)

References 17 publications

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“…Opposing direction of effect of genetic variants on MCP versus low RA may mean that insomnia and other sleep difficulties (for which low RA represents a proxy phenotype) associated with MCP are due to environmental and lifestyle factors related to chronic pain, rather than shared genetic factors predisposing to increased risk for both traits. There was also significant negative genetic correlation between MCP and both AN and ASD, which may be linked to changes in interoception and atypical pain experience seen in individuals with these conditions (Strigo et al, 2013;Bär et al, 2015;Clarke, 2015;Bischoff-Grethe et al, 2018;Gu et al, 2018), and may suggest a genetic basis for increased pain thresholds.…”

Section: Genetic Correlationsmentioning

confidence: 94%

“…This has been observed for Major Depressive Disorder (MDD) (Nicholl et al, 2014;McIntosh et al, 2016), post-traumatic stress-disorder (PTSD) (Shipherd et al, 2007;Dunn et al, 2011;Phifer et al, 2011;Outcalt et al, 2015;Akhtar et al, 2018), schizophrenia (Watson, Chandarana and Merskey, 1981;de Almeida et al, 2013;Engels et al, 2014) and bipolar disorder (BD) (Nicholl et al, 2014;Stubbs et al, 2015). There are also reported differences in the perception of pain and interoception (sensing and integration of bodily signals) for people with schizophrenia (Lévesque et al, 2012;Urban-Kowalczyk, Pigońska and Śmigielski, 2015), anorexia nervosa (AN) (Strigo et al, 2013;Bär et al, 2015;Bischoff-Grethe et al, 2018) and autism spectrum disorders (ASD) (Clarke, 2015;Gu et al, 2018), with some evidence of an increase in pain thresholds for AN and ASD.…”

Section: Genetic Correlationsmentioning

confidence: 95%

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Genome-wide Association Study of Multisite Chronic Pain in UK Biobank

Johnston

Adams

Nicholl

et al. 2018

Preprint

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Chronic pain is highly prevalent worldwide, contributing a significant socioeconomic and public health burden. Several aspects of chronic pain, for example back pain and a severity-related phenotype, chronic pain grade, have been shown to be complex, heritable traits with a polygenic component. Additional pain-related phenotypes capturing aspects of an individual's overall sensitivity to experiencing and reporting chronic pain have also been suggested. We have here made use of a measure of the number of sites of chronic pain in individuals within the general UK population. This measure, termed Multisite Chronic Pain (MCP), is also a complex trait, but its genetic architecture has not previously been investigated. To address this, a large-scale genome-wide association study (GWAS) of MCP was carried out in ~380,000 UK Biobank participants to identify associated genetic variants. Findings were consistent with MCP having a significant polygenic component with a SNP heritability of 10.2%, and 76 independent lead single nucleotide polymorphisms (SNPs) at 39 risk loci were identified. Additional gene-level association analyses identified neurogenesis, synaptic plasticity, nervous system development, cell-cycle progression and apoptosis genes as being enriched for genetic association with MCP. Genetic correlations were observed between MCP and a range of psychiatric, autoimmune and anthropometric traits including major depressive disorder (MDD), asthma and BMI. Furthermore, in Mendelian randomisation (MR) analyses a bi-directional causal relationship was observed between MCP and MDD. A polygenic risk score (PRS) for MCP was found to significantly predict chronic widespread pain (pain all over the body), indicating the existence of genetic variants contributing to both of these pain phenotypes. These findings support the proposition that chronic pain involves a strong nervous system component and have implications for our understanding of the physiology of chronic pain and for the development of novel treatment strategies.

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Section: Genetic Correlationsmentioning

confidence: 94%

Section: Genetic Correlationsmentioning

confidence: 95%

Genome-wide Association Study of Multisite Chronic Pain in UK Biobank

Johnston

Adams

Nicholl

et al. 2018

Preprint

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“…Also, another aspect worth mentioning here is represented by the pain perception in autistic pathology, which is known to be quite a problem, especially considering that now the classical theories stating that most of the ASD patients have lowered or even abolished sensitivity to pain [20,21], are questioned and challenged heavily to this date [22][23][24], since oxytocin was previously cited as having some interesting analgesic effects [25,26].…”

mentioning

confidence: 99%

Intranasal Oxytocin in Autism: Models, Pain and Oxidative Stress

Pădurariu¹,

Antioch²,

Ciobîcă³

et al. 2017

Rev. Chim.

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There is an increased interest in the current literature in how relevant the administration of oxytocin, mostly by using its intranasal administration, could be in some neuropsychiatric disorders and especially in those manifesting a deficit at their sociability level. These aspects made the possible usage of oxytocin as extremely attractive for some management and treatment solutions in the autistic pathology. Thus, we are describing here some original data and current literature status on how oxytocin could help pathophysiological autistic manifestations in both animal models and human patients, by mainly focusing on some specific behavioural or pain manifestations and related oxidative stress status.

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“…Hypo-and hyper-sensitivity to sensory are presented in individuals with autism [Hashimoto, Tayama, & Miyao, 1986]. Of the sensory abnormalities that were recognized for autism is either heightened or reduced sensitivity to pain [Clarke, 2015]. Recently, a neuroimaging study of high-functioning adults with ASD showed heightened brain response to pain anticipation, which is related to social impairments in individuals with autism [Gu et al, 2018].…”

Section: Discussionmentioning

confidence: 99%

Genome‐wide association analysis of autism identified multiple loci that have been reported as strong signals for neuropsychiatric disorders

et al. 2019

Autism Research

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Autism is a common neurodevelopmental disorder with a moderate to a high degree of heritability, but only a few common genetic variants that explain the heritability have been associated. We performed a genome‐wide transmission disequilibrium test analysis of a newly genotyped autism case–parent triad samples (127 trios) in Han Chinese, identified top association signals at multiple single nucleotide polymorphisms (SNPs), including rs9839376 (OR = 2.59, P = 1.27 × 10−05) at KCNMB2, rs6044680 (OR = 0.319, P = 4.82 × 10−05) and rs7274133 (OR = 0.313, P = 3.22 × 10−05) at PCSK2, and rs310619 (OR = 2.40, P = 7.44 × 10−05) at EEF1A2. Furthermore, a genome‐wide combined P‐value of individual SNPs in two independent case–parent triad samples (total 402 triads, n = 1,206) identified SNPs at EGFLAM, ZDHHC2, AGBL1, and SNX29 as additional association signals for autism. While none of these signals achieved a genome‐wide significance in the two samples of our study, they have been reported in a previous genome‐wide association study of neuropsychiatric disorders, and the majority of these SNP have a significant cis‐regulatory association with mRNA in human tissues (false discovery rate (FDR) < 0.05). Our study warrants further study or replication with additional sample for association with autism and other neuropsychiatric disorders. Autism Res 2020, 13: 382–396. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Autism is a common neurodevelopmental disorder, heritable, but only a few common genetic variants that explain the heritability have been associated. We conducted a genome‐wide association study with two cohorts of autism case–parent triad samples in Han Chinese and identified multiple single nucleotide polymorphisms that were reported as strong association signals in a previous genome‐wide association study of other neuropsychiatric disorders or related traits. Our study provides evidence for shared genetic variants among autism and other neuropsychiatric disorders.

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Autism Spectrum Disorder and Amplified Pain

Cited by 39 publications

References 17 publications

Genome-wide Association Study of Multisite Chronic Pain in UK Biobank

Genome-wide Association Study of Multisite Chronic Pain in UK Biobank

Intranasal Oxytocin in Autism: Models, Pain and Oxidative Stress

Genome‐wide association analysis of autism identified multiple loci that have been reported as strong signals for neuropsychiatric disorders

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