Autism spectrum disorder and birth spacing: Findings from the study to explore early development (SEED)

Schieve, Laura A.; Tian, Lin; Drews‐Botsch, Carolyn; Windham, Gayle C.; Newschaffer, Craig J.; Daniels, Julie L.; Lee, Li Ching; Croen, Lisa; Fallin, M. Danielle

doi:10.1002/aur.1887

Cited by 23 publications

(12 citation statements)

References 33 publications

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“…Maternal infection or immune activation during pregnancy is another area of interest and may be a potential risk factor according to recent investigations (62)(63)(64)(65). Both shorter and longer inter-pregnancy intervals have also been reported to increase ASD risk (66). Infants born prematurely have been demonstrated to carry a higher risk for ASD in addition to other neurodevelopmental disorders (34).…”

Section: Causesmentioning

confidence: 99%

Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation

Hodges¹,

Fealko²,

Soares³

2020

Transl Pediatr

541

237

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and the presence of restricted interests and repetitive behaviors (1). In 2013, the Diagnostic and Statistical Manual of Mental Disorders-5 th edition (DSM-5) was published, updating the diagnostic criteria for ASD from the previous 4 th edition (DSM-IV) (Table 1) (1,2).In DSM-5, the concept of a "spectrum" ASD diagnosis was created, combining the DSM-IV's separate pervasive developmental disorder (PDD) diagnoses: autistic disorder, Asperger's disorder, childhood disintegrative disorder, and pervasive developmental disorder not otherwise specified (PDD-NOS), into one. Rett syndrome is no longer included under ASD in DSM-5 as it is considered a discrete neurological disorder. A separate social (pragmatic) communication disorder (SPCD) was established for those with disabilities in social communication, but lacking repetitive, restricted behaviors. Additionally, severity level descriptors were added to help categorize the level of support needed by an individual with ASD.This new definition is intended to be more accurate and works toward diagnosing ASD at an earlier age (3). However, studies estimating the potential impact of moving from the DSM-IV to the DSM-5 have predicted a decrease in ASD prevalence (4,5) and there has been concern that children with a previous PDD-NOS diagnosis would not meet criteria for ASD diagnosis (5-7). There are varying reports estimating the extent of and effects of this change. One study found that with parental report of ASD symptoms alone, the DSM-5 criteria identified 91% of children with clinical DSM-IV PDD diagnoses (8). However, a systematic review suggests only 50% to 75% of

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Section: Causesmentioning

confidence: 99%

Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation

Hodges¹,

Fealko²,

Soares³

2020

Transl Pediatr

541

237

View full text Add to dashboard Cite

show abstract

“…In the study, both short (<12 months) and long (>84 months) inter‐pregnancy intervals (IPI) were associated with twice the risk of ASD in comparison to the IPI of 24 to 47 months ( P < 0.05) . A recent study used data from the Study to Explore Early Development, which consisted of 356 cases with ASD, 627 non‐ASD developmental disabilities cases, and 524 population controls . ASD was associated with IPI less than 18 months and more than 60 months (adjusted OR [aOR], 1.5 [95%CI, 1.1–2.2] and 1.5 [95%CI, 0.99–2.4], respectively).…”

Section: Parental Risk Factorsmentioning

confidence: 99%

“…31 A recent study used data from the Study to Explore Early Development, which consisted of 356 cases with ASD, 627 non-ASD developmental disabilities cases, and 524 population controls. 32 ASD was associated with IPI less than 18 months and more than 60 months (adjusted OR [aOR], 1.5 [95% CI, 1.1-2.2] and 1.5 [95%CI, 0.99-2.4], respectively). The association was stronger amongst the more severe cases of ASD.…”

Section: Parental Risk Factorsmentioning

confidence: 99%

Autism spectrum disorder: Trends in research exploring etiopathogenesis

Gyawali

Patra

2019

Psychiatry Clin Neurosci

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Autism spectrum disorder is a neurodevelopmental condition in which affected individuals have difficulties while interacting and communicating socially, and repetitive behaviors. It has a multifactorial etiology. Various risk factors, including genetic and environmental influences, have been explored while trying to understand its causation. As older evidence was suggestive of a high heritability, a majority of research focused on finding the underlying genetic causes of autism. Due to these efforts, there have been advances in the knowledge of some of the genetic factors associated with autism. But a recent trend also shows an increasing interest in exploration of various potential environmental triggers. These efforts have brought us closer to understanding the elusive disorder more so than ever before. The current review discusses the recent trends in research exploring the etiopathogenesis of autism spectrum disorder.

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“…Similar have been found for schizophrenia 7 . However, a recent study discovered that the relationship of IPI with neurodevelopment was unique to ASD 5 . Most previous studies concentrated on ASD and did not extend to other general neurodevelopment, and the impact of IPI on neurodevelopmental delay is inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Interpregnancy interval and early neurodevelopment in offspring: A Prospective Birth Cohort Study

Ma¹,

Wang

Yang³

et al. 2022

Preprint

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Objective This study aimed to determine the correlation between interpregnancy interval (IPI) and neurodevelopmental delay in infants and to explore the potential mediating role of maternal-fetal glucose metabolism. Design Population based cohort study. Setting China Participants A total of 2559 mother-infant pairs between 2018 and 2022. Methods The prospective birth cohort study included 2559 mother-infant pairs. The IPI is calculated by subtracting the gestational age of the current pregnancy from the interval at the end of the previous pregnancy. Maternal fasting venous blood collection at 24-28 weeks and cord blood collection at delivery. The association between IPI and neurodevelopment was determined by logistic regression. Main outcome measures Neurodevelopmental outcomes at 12 months in offspring were assessed by the Ages and Stages Questionnaire Edition 3 (ASQ-3). Results In our cohort, 14.0% had an IPI <12 months. IPI <12 months increased the failure of the communication domain, fine motor domain, and personal social domain of the ASQ [relative risks (RRs) with 95% confidence interval (CI): 1.75(1.13, 2.72); 1.77(1.13, 2.77); 1.51(1.01, 2.28)]. Maternal homeostasis model assessment of insulin resistance (HOMA-IR) and cord blood C-peptide was significantly associated with failure in the communication domain [RRs with 95% CI: 1.15(1.02, 1.31); 2.15(1.26, 3.67)]. The proportion of the association between IPI and failure of the communication domain risk mediated by maternal HOMA-IR and cord blood C-peptide was 14.4%. Conclusions IPI <12 months was associated with failing the communication domain in offspring. Maternal-fetal glucose metabolism abnormality may partially explain the neurodevelopmental delay caused by short IPI.

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Autism spectrum disorder and birth spacing: Findings from the study to explore early development (SEED)

Cited by 23 publications

References 33 publications

Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation

Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation

Autism spectrum disorder: Trends in research exploring etiopathogenesis

Interpregnancy interval and early neurodevelopment in offspring: A Prospective Birth Cohort Study

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