Autism spectrum disorder is associated with gut microbiota disorder in children

Sun, Hairong; You, Zhong; Jia, Libo; Wang, Fang

doi:10.1186/s12887-019-1896-6

Cited by 38 publications

(31 citation statements)

References 24 publications

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“…Our results indicated that n-3/n-6 PUFAs (1:5) supplementation improved the behavioral patterns of autistic rats by reducing Firmicutes in their intestines. Sun et al found that the average abundance of Prevotellaceae in the ASD group was lower than in healthy children (25). Our findings showed that the abundance of Prevotellaceae in the VPA group was lower than that in the control group at the genus level.…”

Section: Discussionsupporting

confidence: 45%

“…The change of intestinal flora in autistic patients mainly, are manifested by the significant increase of intestinal bacterial translocation, the elevated amount of clostridium species, increased Desulfovibrio, and decreased bifidobacteria. Compared with neurotypical children, the intestinal flora abundance is decreased in children with autism (25).…”

Section: Discussionmentioning

confidence: 93%

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Effects of Dietary Fat Profile on Gut Microbiota in Valproate Animal Model of Autism

Wang

Hou

et al. 2020

Front. Med.

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Autism spectrum disorder (ASD) is a developmental disability which may cause significant social, communication, and behavioral challenges. Besides certain essential symptoms, a lot of ASD individuals also suffer the comorbidity of gut microbiota dysbiosis, which possibly causes a variety of gastrointestinal (GI) difficulties. Interestingly, evidence has indicated that behavioral output may be modulated through the communication between the central nervous system and gut microbiota via the gut-brain axis. Polyunsaturated fatty acids (PUFAs) and n-3 fatty acids (n-3 PUFA) are structurally and functionally crucial components for the brain, and the state of n-3 PUFAs also affects the gut microbiota. However, how varying intake ratios of n-3/n6 PUFAs affect the gut microbiota composition in ASDs is not well-understood. Pregnant female Wistar rats with intraperitoneal administration of valproate acid (VPA) at embryonic day (E) 12.5 and their male offspring were grouped and fed three diets: a control chow (VPA group), omega-3 deficient (A group), and n-3/n6 (1:5) diet (B group). The diet of pregnant female Wistar rats with intraperitoneal administration of saline and their male offspring was a control chow (normal group). Microbial composition and species abundance were investigated accordingly by the 16S rRNA gene-based metagenomics analysis on the fecal samples. Results showed that fecal microbial abundance was decreased because of VPA administration in the period of pregnancy, and the changing pattern of gut microbiota was similar to that reported in ASD patients. Furthermore, the n-3/n6 (1:5) diet increased the fecal microbial abundance and decreased the elevated Firmicutes. In conclusion, n-3/n6 PUFAs (1:5) diet supplementation may alter gut microbiota composition in VPA-exposed rats. This study put forward a new strategy for the intervention and treatment of autism by n-3/n-6 PUFAs ratio supplementation intakes.

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Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 93%

Effects of Dietary Fat Profile on Gut Microbiota in Valproate Animal Model of Autism

Wang

Hou

et al. 2020

Front. Med.

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“…Authors were contacted when the required data were not available. In this regard, although the study by Sun et al [30] met the main inclusion criteria, it was not included in the meta-analysis due to the lack of necessary data and no response from the authors.…”

Section: Resultsmentioning

confidence: 99%

Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

et al. 2020

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Background: Autism spectrum disorder (ASD) is a public health problem and has a prevalence of 0.6%–1.7% in children. As well as psychiatric symptoms, dysbiosis and gastrointestinal comorbidities are also frequently reported. The gut–brain microbiota axis suggests that there is a form of communication between microbiota and the brain underlying some neurological disabilities. The aim of this study is to describe and compare the composition of gut microbiota in children with and without ASD. Methods: Electronic databases were searched as far as February 2020. Meta-analyses were performed using RevMan5.3 to estimate the overall relative abundance of gut bacteria belonging to 8 phyla and 17 genera in children with ASD and controls. Results: We included 18 studies assessing a total of 493 ASD children and 404 controls. The microbiota was mainly composed of the phyla Bacteroidetes, Firmicutes, and Actinobacteria, all of which were more abundant in the ASD children than in the controls. Children with ASD showed a significantly higher abundance of the genera Bacteroides, Parabacteroides, Clostridium, Faecalibacterium, and Phascolarctobacterium and a lower percentage of Coprococcus and Bifidobacterium. Discussion: This meta-analysis suggests that there is a dysbiosis in ASD children which may influence the development and severity of ASD symptomatology. Further studies are required in order to obtain stronger evidence of the effectiveness of pre- or probiotics in reducing autistic behaviors.

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“…Three populations were found to signi cantly increase over time in the boy group: Selenomonadales,Negativicutes and Veillonellaceae. A recent study suggests that lower abundances of Selenomonadales and Veillonellaceae are associated with autism spectrum disorder 39,40 . Dysregulation of Selenomonadales affects gut secretion and in turn affects brain function by modulating the e cacy of the vagal response 41 .…”

Section: Discussionmentioning

confidence: 99%

Delivery, Feeding and Gender Differently Contribute to Infant Gut Microbiota Development

Ding

Ren

et al. 2021

Preprint

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To characterize gut microbiome of the infant during the first year of life and assess the different contributions of delivery mode, feeding mode and infant gender to gut microbial development. We collected 314 faecal samples from 80 infants at 5 time points of 0, 1st, 3rd, 6th and 12th months prospectively, and finally 213 samples completed Miseq sequencing and analysis. We characterized gut microbiome of the infant at the different phases and evaluated the different contributions of delivery mode, feeding mode and gender to gut microbial development. Delivery mode, gender and feeding mode were the strongest factors determining gut microbiome colonization at 0 months, from 1 month to 6 months and 12 months, respectively. Four genera including Bifidobacterium, Bacteroides, Parabacteroides and Phascolarctobacterium were increased, whereas 10 genera e.g. Salmonella and Enterobacter were reduced, in vaginal delivery versus cesarean section. Two genera including Peptostreptococcaceae incertae sedis and Anaerococcus were increased, whereas 3 genera e.g. Coriobacteriaceae uncultured were reduced, in exclusive breastfeeding versus combined feeding. This study indicated the contribution degrees of delivery mode, feeding mode and gender to gut microbial initiation and evolvement, and reported microbial differences induced by the different delivery mode, feeding mode and gender.

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Autism spectrum disorder is associated with gut microbiota disorder in children

Cited by 38 publications

References 24 publications

Effects of Dietary Fat Profile on Gut Microbiota in Valproate Animal Model of Autism

Effects of Dietary Fat Profile on Gut Microbiota in Valproate Animal Model of Autism

Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Delivery, Feeding and Gender Differently Contribute to Infant Gut Microbiota Development

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