The expressions of Autism Spectrum Disorder (ASD) in children are explored in this research, with particular attention given to challenging behaviors, personal self-care capabilities, and adaptive behaviors. Insights into the unique difficulties faced by children with ASD are sought after. A sample of 60 children, aged 24 to 84 months, consisting of 40 boys and 20 girls, was engaged in the study, utilizing the Psychoeducational Profile – Third Edition (PEP-3) for assessment. Although no statistically significant distinctions were found between genders in the measured areas, possible gender-specific manifestations and challenges in ASD were identified by the research. Gender-sensitive approaches are suggested to be necessary for diagnosing, assessing, and developing interventions for ASD based on the research findings. Future studies should consider adopting longitudinal designs, utilizing gender-balanced samples, and collecting detailed sociodemographic data to enhance understanding and refine support strategies for children with ASD.