2011
DOI: 10.1177/070674371105601204
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Autism Spectrum Disorders and Maternal Serum alpha-Fetoprotein Levels during Pregnancy

Abstract: Objective: Numerous studies have been trying to disentangle the complex pathophysiology of autism spectrum disorders (ASD). In our study, we explored the potential role of maternal serum (MS) alpha-fetoprotein (AFP) in the prediction and the pathophysiology of ASD.Methods: A total of 112 patients with ASD and 243 control subjects were included in a case-control study, using a historic birth cohort maintained at Statens Serum Institute. Measurements of MS-AFP were obtained from a multicentre screening program, … Show more

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Cited by 4 publications
(2 citation statements)
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“…AFP has a direct relationship with ASD in that it is elevated in the maternal serum of mothers giving birth to children later diagnosed with ASD [89]. Mothers with ASD children exhibited maternal serum AFP levels that were significantly elevated compared with control subjects.…”
Section: Discussionmentioning
confidence: 99%
“…AFP has a direct relationship with ASD in that it is elevated in the maternal serum of mothers giving birth to children later diagnosed with ASD [89]. Mothers with ASD children exhibited maternal serum AFP levels that were significantly elevated compared with control subjects.…”
Section: Discussionmentioning
confidence: 99%
“…Distribution of ABO blood types in fathers/mothers of children with ASD and the control population showed no statistically significant differences (χ 2 = 7.01, df = 6, P = 0.28) ( Table 1). Numerous studies have been trying to disentangle the complex pathophysiology of ASDs [9]. In this study, we postulated that specific blood type of parents may contribute to the risk of autism with some unknown genetic mechanism which subsequently disrupts fetal neurodevelopment.…”
mentioning
confidence: 98%