Autism symptoms, depression, and active social avoidance in schizophrenia: Association with self-reports and informant assessments of everyday functioning

Harvey, Philip D.; Deckler, Elizabeth; Jones, Mackenzie T.; Jarskog, L. Fredrik; Penn, David L.; Pinkham, Amy E.

doi:10.1016/j.jpsychires.2019.05.010

Cited by 54 publications

(57 citation statements)

References 41 publications

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“…ASD symptoms are more frequent in subjects diagnosed with SSD than in healthy controls (33,34), and appear to play a relevant role in the clinical situation of patients with SSD, as more severe ASD symptoms represent an individual predictor of worse SC performance (35,36) and poorer real-world social functioning (37), and are correlated with greater impairments in the ability to judge the quality of everyday functioning (38). Individuals diagnosed with SSD and showing prominent ASD features could represent a particular sub-population with specific clinical characteristics, including lower IQ and poorer cognitive performance (39,40) and worse response to antipsychotic treatment (41).…”

Section: Schizophrenia and Autism Spectra Disorders: Areas Of Clinicamentioning

confidence: 99%

Social Cognition in a Research Domain Criteria Perspective: A Bridge Between Schizophrenia and Autism Spectra Disorders

et al. 2020

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Schizophrenia and autism spectra disorders are currently conceptualized as distinct clinical categories. However, the relationship between these two nosological entities has been revisited in recent years due to the evidence that they share some important clinical and neurobiological features, putting into question the nature and the extent of their commonalities and differences. In this respect, some core symptoms that are present in both disorders, such as social cognitive deficits, could be a primary target of investigation. This review briefly summarizes the commonalities and overlapping features between schizophrenia and autism spectra disorders in social cognitive functions, considering this construct in a Research Domain Criteria perspective. The clinical manifestation of deficits in social cognition are similar in schizophrenia spectrum disorders and autism spectrum disorders, and brain areas that appear to be altered in relation to these impairments are largely shared; however, the results of various studies suggest that, in some cases, the qualitative nature of these alterations may be different in the two spectra. Moreover, relevant differences could be present at the level of brain networks and connections. More research is required in this field, regarding molecular and genetic aspects of both spectra, to better define the neurobiological mechanisms involved in social cognition deficits, with the objective of developing specific and targeted treatments.

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Section: Schizophrenia and Autism Spectra Disorders: Areas Of Clinicamentioning

confidence: 99%

Social Cognition in a Research Domain Criteria Perspective: A Bridge Between Schizophrenia and Autism Spectra Disorders

et al. 2020

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“…ASDs symptoms are more frequent in people diagnosed with schizophrenia than in healthy subjects [16,17], and, in people with SSDs, more severe ASD symptoms emerged as predictors of poorer performance on different measures of social cognitive abilities, both in the emotion processing and in the mental state attribution/ theory of mind domains [18]. Prominent ASD symptoms have also been linked to poorer real-world functioning and greater impairments in the ability to judge the quality of everyday functioning [19].…”

Section: Introductionmentioning

confidence: 99%

The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study

et al. 2020

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Background. Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic disorder but their relationships with cognitive aspects and functional outcomes of the disease remain to be addressed in large samples of individuals. Aims. To investigate the clinical, cognitive, and functional correlates of ASD symptoms in a large sample of people diagnosed with schizophrenia. Methods. The severity of ASD symptoms was measured with the PANSS Autism Severity Scale (PAUSS) in 921 individuals recruited for the Italian Network for Research on Psychoses multicenter study. Based on the PAUSS scores, three groups of subjects were compared on a wide array of cognitive and functional measures. Results. Subjects with more severe ASD symptoms showed a poorer performance in the processing speed (p = 0.010), attention (p = 0.011), verbal memory (p = 0.035), and social cognition (p = 0.001) domains, and an overall lower global cognitive composite score (p = 0.010). Subjects with more severe ASD symptoms also showed poorer functional capacity (p = 0.004), real-world interpersonal relationships (p < 0.001), and participation in community-living activities (p < 0.001). Conclusions. These findings strengthen the notion that ASD symptoms may have a relevant impact on different aspects of the disease, crucial to the life of people with schizophrenia. Prominent ASD symptoms may characterize a specific subpopulation of individuals with SSD.

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“…Recent studies show that greater severity of ASD symptoms in patients with schizophrenia spectrum disorders predicts poorer performance on different social cognitive tests, both in the emotion processing and in the mental state attribution/theory of mind domains (19). Some authors have also hypothesized that schizophrenia patients with prominent ASD symptoms may represent a subpopulation with specific clinical characteristics (12), including poorer real-world functioning and greater impairments in the ability to judge the quality of their everyday functioning (20). Impairment in real-world settings remains one of the most problematic issues that patients with schizophrenia have to face.…”

Section: Introduction Backgroundmentioning

confidence: 99%

Autistic Symptoms and Social Cognition Predict Real-World Outcomes in Patients With Schizophrenia

et al. 2020

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Objective: Real-world functioning is a complex construct influenced by different factors. The impact of social cognition and autism spectrum disorder (ASD) symptoms on different aspects of the life of people with schizophrenia has been demonstrated independently, but it is unclear how these factors are related to functioning when considered concurrently. We hypothesized that ASD symptoms could play a major role in predicting real-world functioning in schizophrenia. Methods: Existent databases from two studies (SCOPE Phase 3 and SCOPE Phase 5), in which a total of 361 patients (mean age 41.7 years; 117 females) were assessed with measures of symptom severity, neuro-and socio-cognitive abilities, functional capacity, social skills, and informant-reported real-world functioning outcomes, were analyzed. Results: Active social avoidance, social skills, ASD symptoms, and emotion processing emerged as predictors of real-world interpersonal relationships. Cognitive performance, positive symptoms, and functional capacity emerged as predictors of real-world participation in daily activities. Cognitive performance, emotion processing, positive symptoms severity, and social skills emerged as predictors of real-world work outcomes. Conclusion: Among other demographic, clinical, and functional capacity variables, increased ASD symptoms emerged as a significant predictor of poorer social relationships and may therefore represent a key factor in predicting real-world social functioning in schizophrenia.

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Autism symptoms, depression, and active social avoidance in schizophrenia: Association with self-reports and informant assessments of everyday functioning

Cited by 54 publications

References 41 publications

Social Cognition in a Research Domain Criteria Perspective: A Bridge Between Schizophrenia and Autism Spectra Disorders

Social Cognition in a Research Domain Criteria Perspective: A Bridge Between Schizophrenia and Autism Spectra Disorders

The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study

Autistic Symptoms and Social Cognition Predict Real-World Outcomes in Patients With Schizophrenia

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