Autism symptoms in toddlers with Down syndrome: a descriptive study

Hepburn, Susan; Philofsky, Amy; Fidler, Deborah J.; Rogers, Sally J.

doi:10.1111/j.1468-3148.2007.00368.x

Cited by 71 publications

(48 citation statements)

References 21 publications

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“…These figures are broadly consistent with the majority of previous prevalence estimates reported within the DS population (Capone et al, 2005;Hepburn et al, 2008;Kent et al, 1999;Lowenthal et al, 2007;Lund, 1988;Turk and Graham, 1997). However, they are higher than that reported by Gillberg et al (1986) and Ghaziuddin et al (1992) (both 5%) and lower than that reported by Starr et al, 2005 (39%).…”

Section: Prevalence and Profile Of Asd Symptomatology In Dssupporting

confidence: 92%

“…These findings are consistent with reports from Capone et al (2005), Carter et al (2007), Hepburn et al (2008) and Molloy et al (2009). A comparison of individuals with DS scoring above the cut-off for ASD with those meeting the more stringent criteria for autism was limited by the small sample size but indicated that those scoring above the cut-off for ASD only were more able than those who scored above the cut-off for autism.…”

Section: Prevalence and Profile Of Asd Symptomatology In Dssupporting

confidence: 92%

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Prevalence of autism spectrum disorder symptomatology and related behavioural characteristics in individuals with Down syndrome

Moss

Richards

Nelson

et al. 2012

Autism

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We evaluated the proportion of individuals with Down syndrome (DS: N = 108) who met criteria for autism spectrum disorder (ASD) on the Social Communication Questionnaire and the severity of ASD-related symptomatology in this group. The proportions of individuals with DS meeting the cut-off for ASD and autism in this sample were 19% and 8%, respectively. We then evaluated the behavioural profile of individuals with DS who scored above cut-off for ASD (DS+ASD; N = 17) compared with those with DS-only (N = 17) and individuals with idiopathic ASD (N = 17), matched for adaptive behaviour skills and ASD symptom severity (ASD group only). Individuals in the DS+ASD and ASD-only groups showed more stereotyped behaviour, repetitive language, overactivity and self-injury than the DS-only group (p < .001). Individuals in the DS+ASD and DS-only groups appeared less withdrawn from their surroundings than those with ASD (p < .004). These findings indicate differences in the behavioural and cognitive profile of individuals with DS+ASD compared with those with DS-only, when controlling for adaptive behaviour skills. Individuals with DS+ASD show broad similarities with individuals with idiopathic ASD with regard to ASD and behavioural characteristics but may also show some areas of subtle difference from this group.

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Section: Prevalence and Profile Of Asd Symptomatology In Dssupporting

confidence: 92%

Section: Prevalence and Profile Of Asd Symptomatology In Dssupporting

confidence: 92%

Prevalence of autism spectrum disorder symptomatology and related behavioural characteristics in individuals with Down syndrome

Moss

Richards

Nelson

et al. 2012

Autism

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“…Additionally, an increasing incidence of individuals diagnosed with DS and comorbid 10 Daunhauer and Fidler autism has been reported in the literature (Dykens, 2007;Hepburn, Philofsky, Fidler, & Rogers, 2008;Kent, Evans, Paul, & Sharp, 1999). While once thought to occur at low rates in the DS population (1%-2%, see Dykens, 2007, for a review), currently, 5%-10% of children with DS also meet the criteria for autistic spectrum disorder (DiGuiseppi et al, 2010;Hepburn et al, 2008;Kent et al, 1999;Lowenthal, Paula, Schwartzman, Brunoni, & Mercadante, 2007). Below we address strengths and challenges in performance skills pertinent to occupational therapy practice.…”

Section: Client Factors: Body Functionsmentioning

confidence: 94%

The Down Syndrome Behavioral Phenotype: Implications for Practice and Research in Occupational Therapy

Daunhauer

Fidler

2011

Occupational Therapy In Health Care

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Down syndrome (DS) is the most common chromosomal cause of intellectual disability. The genetic causes of DS are associated with characteristic outcomes, such as relative strengths in visual-spatial skills and relative challenges in motor planning. This profile of outcomes, called the DS behavioral phenotype, may be a critical tool for intervention planning and research in this population. In this article, aspects of the DS behavioral phenotype potentially relevant to occupational therapy practice are reviewed. Implications and challenges for etiology-informed research and practice are discussed.

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“…ASD affects about 1 in 68 children (Centers for Disease Control and Prevention 2014) and is defined by deficits in sociocommunicative behaviors, the presence of odd or stereotypical behaviors, a restricted range of interests, and, sometimes, intellectual or language deficits. However, children with other developmental disabilities frequently display symptoms that overlap with those of children with ASD (Hepburn et al 2008;Klein-Tasman et al 2009), including significantly more behavioral and emotional problems than typically-developing peers (Baker et al 2003;Eisenhower et al 2005). Because symptoms associated with ASD vary in severity along a broad continuum, it is potentially helpful to study relations between the severity of these ASD-associated symptoms and parenting stress, as well as contributors to that stress, regardless of diagnostic classification.…”

Section: Introductionmentioning

confidence: 97%

Predictors of Parenting Stress in Children Referred for an Autism Spectrum Disorder Diagnostic Evaluation

2015

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Parents of children with autism spectrum disorder (ASD) report significantly higher stress than parents of children with other developmental disorders. Symptoms that overlap with the autism spectrum are often present in other developmental disorders, which could significantly increase parenting stress. Additionally, the severity of ASD symptoms within a group of children with ASD can greatly vary. In the present study, problem behaviors, cognitive and adaptive functioning, and parenting stress were examined in a group of 40 children aged 2-5 years who were referred for an autism evaluation. The children presented with varying levels of symptoms often associated with ASD, and some met criteria for an autism spectrum disorder diagnosis. This approach allowed for both categorical and dimensional consideration of ASDassociated symptoms and the relation to parenting stress in children with and without autism. When examined based on ultimate clinical diagnosis of ASD or non-ASD, child behavior problems and parenting stress were similar across groups. Clinicianbased autism severity ratings (based on the Autism Diagnostic Observation Schedule) did not significantly predict parenting stress; however, parental report of the severity of ASD-associated symptoms (from the Social Responsiveness Scale) showed a significant relation to stress. Cognitive ability did not uniquely contribute to stress. Problem behaviors as assessed by the Child Behavior Checklist accounted for the largest proportion of the variance in parenting stress; adaptive behaviors and severity of parent-or clinician-rated autism-associated symptoms did not uniquely contribute above and beyond problem behaviors. Parents who reported more behavior problems or more autism-associated symptoms reported higher parenting stress. Clinical applications and the need for more research on parenting stress and problem behaviors in children displaying autism symptomatology are highlighted. J Dev Phys Disabil

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Autism symptoms in toddlers with Down syndrome: a descriptive study

Abstract: Background-Research suggests that children with Down syndrome may be at increased risk of having an autism spectrum disorder; however, previous studies have not utilized comprehensive, state-of-the-art diagnostic tools to address the question of comorbid autism and Down syndrome.

Cited by 71 publications

References 21 publications

Prevalence of autism spectrum disorder symptomatology and related behavioural characteristics in individuals with Down syndrome

Prevalence of autism spectrum disorder symptomatology and related behavioural characteristics in individuals with Down syndrome

The Down Syndrome Behavioral Phenotype: Implications for Practice and Research in Occupational Therapy

Predictors of Parenting Stress in Children Referred for an Autism Spectrum Disorder Diagnostic Evaluation

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