Autistic‐spectrum disorders in down syndrome: Further delineation and distinction from other behavioral abnormalities

Carter, John C.; Capone, George T.; Gray, Robert M.; Cox, Christiane; Kaufmann, Walter E.

doi:10.1002/ajmg.b.30407

Cited by 80 publications

(61 citation statements)

References 22 publications

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“…Even if the present study confirmed previous data of a relatively high prevalence of Anxiety disorder also in individuals with DS (more than 14%), results from the direct comparison between participants with DS and participants with WS support evidence indicating how Anxiety disorder is less common in DS than in other populations with ID [52][53][54].…”

Section: Discussionsupporting

confidence: 74%

Detecting Psychiatric Profile in Genetic Syndromes: A Comparison of Down Syndrome and Williams Syndrome

Vicari¹,

Costanzo²,

Arm³

et al. 2016

J Genet Syndr Gene Ther

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The occurrence and co-occurrence of psychiatric disorders have been more frequently reported in people with Intellectual Disability (ID) than in the general population. The present study was aimed at verifying whether the psychiatric profile of individuals with ID is just a consequence of ID or derives from a specific genotype. The psychiatric profile of 112 individuals with Down syndrome (DS) and 85 with Williams syndrome (WS) was examined. The interactions between psychiatric symptom clusters and the effect of age were also investigated.Participants with WS had higher rates of psychiatric disorders, and, specifically, of Anxiety disorders and Psychosis than DS. However, the psychiatric profile changed by age, since Anxiety disorder was higher in individuals with WS compared to DS in young age, while Psychosis in old age. A relation between the occurrence of disorders, as Anxiety disorder and Mood Disorder, was found only in participants with WS. Moreover, distinct Anxiety and Behavior Disorder subtypes emerged between groups.Results indicate that the genetic etiology of ID differently affects the psychiatric characteristics of the groups and suggest the importance of a targeted psychiatric care for individuals with WS and DS.

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Section: Discussionsupporting

confidence: 74%

Detecting Psychiatric Profile in Genetic Syndromes: A Comparison of Down Syndrome and Williams Syndrome

Vicari¹,

Costanzo²,

Arm³

et al. 2016

J Genet Syndr Gene Ther

View full text Add to dashboard Cite

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“…In-depth characterizations of other genetic disorders associated with ASD such as Down syndrome are in progress [25,26]. If their findings agree with those of FXS, they will solidify the notion of ASD as a selective disorder in intellectual disability, and should lead to a greater understanding of genetic contributions to ASD.…”

Section: Intellectual Disability In Fxs: Diagnosis Of Asd Reflects Sementioning

confidence: 99%

What Can We Learn about Autism from Studying Fragile X Syndrome?

Budimirović

Kaufmann²

2011

Dev Neurosci

Self Cite

165

140

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Despite early controversy, it is now accepted that a substantial proportion of children with fragile X syndrome (FXS) meets diagnostic criteria for autism spectrum disorder (ASD). This change has led to an increased interest in studying the association of FXS and ASD because of the clinical consequences of their co-occurrence and the implications for a better understanding of ASD in the general population. Here, we review the current knowledge on the behavioral, neurobiological (i.e., neuroimaging), and molecular features of ASD in FXS, as well as the insight into ASD gained from mouse models of FXS. This review covers critical issues such as the selectivity of ASD in disorders associated with intellectual disability, differences between autistic features and ASD diagnosis, and the relationship between ASD and anxiety in FXS patients and animal models. While solid evidence supporting ASD in FXS as a distinctive entity is emerging, neurobiological and molecular data are still scarce. Animal model studies have not been particularly revealing about ASD in FXS either. Nevertheless, recent studies provide intriguing new leads and suggest that a better understanding of the bases of ASD will require the integration of multidisciplinary data from FXS and other genetic disorders.

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“…In the largest clinical cohort of children with Down syndrome and ASD reported to date, Capone et al [2005] and Carter et al [2007] used two behavioral checklists to differentiate their 64 cases of children with Down syndrome and ASD from other Down syndrome patients with or without other psychiatric conditions. Children with Down syndrome and ASD had lower IQ's, and more severe, odd stereotypic behaviors, anxiety, and social withdrawal.…”

Section: Childrenmentioning

confidence: 99%

Psychiatric and behavioral disorders in persons with Down syndrome

Dykens

2007

Ment. Retard. Dev. Disabil. Res. Rev.

210

150

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Similar to the state of the broader intellectual disabilities field, many gaps exist in the research and treatment of mental health concerns in people with Down syndrome. This review summarizes key findings on the type and prevalence of behavior and emotional problems in children, adolescents, and adults with Down syndrome. Such findings include relatively low rates of severe problems in children, and well-documented risks of depression and Alzheimer's disease in older adults. The review also considers emerging data on autism, and the paucity of studies on adolescents. Three next steps for research are highlighted, including a need to: (1) connect research on psychiatric status and diagnoses across developmental periods, including adolescence, and to examine such associated processes as sociability, anxiety and attention; (2) unravel complicated biopsycho-social risk and protective factors that serve to increase or diminish psychopathology; and (3) identify evidence-based treatments that both reduce distressful symptoms and enhance well-being in individuals with Down syndrome.

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Autistic‐spectrum disorders in down syndrome: Further delineation and distinction from other behavioral abnormalities

Cited by 80 publications

References 22 publications

Detecting Psychiatric Profile in Genetic Syndromes: A Comparison of Down Syndrome and Williams Syndrome

Detecting Psychiatric Profile in Genetic Syndromes: A Comparison of Down Syndrome and Williams Syndrome

What Can We Learn about Autism from Studying Fragile X Syndrome?

Psychiatric and behavioral disorders in persons with Down syndrome

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