Auto Anti-M Antibody Following Renal Transplantation

Lown, J.A.G.; Barr, A.L.; Kelly, A.

doi:10.1159/000467012

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Over the past years search for brain-derived EVs as peripheral non-invasive biomarker(s) for neurodegenerative diseases has gained momentum [24,25]. Based on the premise that in the CNS the expression of cell adhesion molecule L1CAM is primarily restricted to neurons, the presence of this protein in the exosomes demonstrates its neuronal origin [26][27][28]. EVs derived from cultured cortical neurons have been demonstrated to exhibit cell adhesion molecule L1 (L1CAM) on their surface, with implications for various neurodegenerative diseases [28].…”

Section: Introductionmentioning

confidence: 99%

Neuronal‐derived extracellular vesicles are enriched in the brain and serum of HIV‐1 transgenic rats

Dagur

Liao

Sil

et al. 2019

J of Extracellular Vesicle

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Despite the efficacy of combination antiretroviral therapy (ART) in controlling human immunodeficiency virus (HIV-1) replication, cytotoxic viral proteins such as HIV-1 transactivator of transcription (Tat) persist in tissues such as the brain. Although HIV-1 does not infect neuronal cells, it is susceptible to viral Tat protein-mediated toxicity, leading to neuroinflammation that underlies HIV-associated neurocognitive disorders (HAND). Given the role of extracellular vesicles (EVs) in both cellular homoeostasis and under pathological conditions, we sought to investigate the alterations in the quantity of neuronal-derived EVs in the brainas defined by the presence of cell adhesion molecule L1 (L1CAM) and to evaluate the presence of L1CAM + EVs in the peripheral circulation of HIV-1 transgenic (HIV-1 Tg) rats. The primary goal of this study was to investigate the effect of long-term exposure of HIV-1 viral proteins on the release of neuronal EVs in the brain and their transfer in the systemic compartment. Brain and serum EVs were isolated from both wild type and HIV-1 Tg rats using differential ultracentrifugation with further purification using the Optiprep gradient method. The subpopulation of neuronal EVs was further enriched using immunoprecipitation. The current findings demonstrated increased presence of L1CAM + neuronal-derived EVs both in the brain and serum of HIV-1 Tg rats.

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Section: Introductionmentioning

confidence: 99%

Neuronal‐derived extracellular vesicles are enriched in the brain and serum of HIV‐1 transgenic rats

Dagur

Liao

Sil

et al. 2019

J of Extracellular Vesicle

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show abstract

“…There are reports of 7 cases of auto-anti-M (6 females, 1 male), who had no evidence of antibody activity in vivo [4,6,7,9,18,19], and a further two cases (both females) associated with chronic CHAD (2,16). Of these 9 cases with autoanti-M, 3 were MM and 6 MN.…”

Section: Discussionmentioning

confidence: 99%

Chronic Cold Haemagglutinin Disease Due to an Anti-M-Like Autoantibody

Chapman¹,

Murphy²,

Waters³

1982

Vox Sanguinis

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A case of chronic cold haemagglutinin disease due to an IgM monoclonal (kappa) autoantibody with anti-M-like specificity is described in a patient with the MN phenotype. The autoantibody was present in very high titre and active at body temperature, but haemolysis was only mild. The direct antiglobulin test was positive due to C(3)d on the patient’s red cells, and the autoantibody was able to bind complement to normal MM and MN cells with a marked dosage effect.

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In vitro reactions with red blood cells that are not due to blood group antibodies: a review

Garratty

1998

Immunohematology

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Auto Anti-M Antibody Following Renal Transplantation

Cited by 3 publications

References 7 publications

Neuronal‐derived extracellular vesicles are enriched in the brain and serum of HIV‐1 transgenic rats

Neuronal‐derived extracellular vesicles are enriched in the brain and serum of HIV‐1 transgenic rats

Chronic Cold Haemagglutinin Disease Due to an Anti-M-Like Autoantibody

In vitro reactions with red blood cells that are not due to blood group antibodies: a review

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