Auto-Antibodies in Hashimoto's Disease (Lymphadenoid Goitre)

Roitt, Ivan M.; Doniach, Deborah; Campbell, P. N.; Hudson, Rupert Vaughan

doi:10.1016/s0140-6736(56)92249-8

Cited by 515 publications

(129 citation statements)

References 4 publications

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“…The association has been confirmed by subsequent reports (Table 7). Hashimoto's thyroiditis (lymphocytic thyroiditis), was first described by Roitt et al in 1956, and is also a common condition in the Down syndrome population (Saxena & Crawford, 1962;Leboeuf & Bongiovanni, 1964).…”

Section: Immunological Aspectsmentioning

confidence: 99%

Down Syndrome and Thyroid Disorders: A Review

Prasher¹

1999

Downs Syndr. Res. Pract.

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Thyroid disorders are common in the Down syndrome population but many specific areas of importance remain to be resolved. A detailed review of previously published case reports and research studies highlighting the clinical association between Down syndrome and thyroid disorders was undertaken. Historical, epidemiological, immunological, diagnostic and treatment issues are addressed. Recommendations for future management and research are considered.

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Section: Immunological Aspectsmentioning

confidence: 99%

Down Syndrome and Thyroid Disorders: A Review

Prasher¹

1999

Downs Syndr. Res. Pract.

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“…Hashimoto's thyroiditis, the most common autoimmune disease affecting humans, is an example of organ-specific autoimmunity with a strong humoral component [1][2][3]. This humoral response is manifest by IgG class autoantibodies to thyroid peroxidase (TPO), previously known as the thyroid microsomal antigen (reviewed in [4]).…”

Section: Introductionmentioning

confidence: 99%

Thyroid peroxidase autoantibody epitopic ‘fingerprints’ in juvenile Hashimoto’s thyroiditis: evidence for conservation over time and in families

Jaume

Burek

Hoffman

et al. 1996

Clinical and Experimental Immunology

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SUMMARYIn Hashimoto's thyroiditis, the humoral component is manifest by autoantibodies to thyroid peroxidase (TPO). Epitopic 'fingerprinting' of polyclonal serum TPO autoantibodies has been facilitated by the molecular cloning and expression as Fab of a repertoire of human TPO autoantibody genes. To investigate whether TPO autoantibody fingerprints are (i) stable over long periods of time ( 15 years), and (ii) inherited, we studied a cohort of nine patients with juvenile Hashimoto's thyroiditis and 21 first degree relatives of four of these patients. Fingerprints were determined by competition between four selected Fab and serum autoantibodies for binding to 125 I-TPO. Regardless of titre, the TPO epitopic profile was stable in 10/12 individuals whose TPO autoantibody levels were sufficient for analysis on two or three occasions over 12-15 years. Although the TPO epitopic fingerprint profiles in two families raised the possibility of inheritance, overall the data from all four families did not reveal an obvious pattern of genetic control. In no family was the TPO epitopic fingerprint associated with HLA A, B or DR. In conclusion, TPO autoantibody epitopic fingerprints are frequently conserved over many years. Studies on additional families are necessary to establish whether or not the epitopic profiles of TPO autoantibodies are inherited.

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“…This pathological entity was first described by Hashimoto in 1912 who reported four patients with goiter in whom the histology of the thyroid gland was characterised by diffuse lymphocyte infiltration, atrophy of follicular cells, presence of eosinophilic granular thyrocytes (also worded oncocytic cells or Hurtle's cells) and fibrosis (Hashimoto, 1912). Over 40 years later, presence of autoantibodies was discovered in patients with this disorder and HT was finally categorised as a chronic autoimmune thyroiditis (Roitt et al, 1956).…”

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confidence: 99%

Detection and molecular characterisation of thyroid cancer precursor lesions in a specific subset of Hashimoto's thyroiditis

Gasbarri

Sciacchitano²,

Marasco

et al. 2004

Br J Cancer

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Hashimoto's thyroiditis (HT) represents the most common cause of hypothyroidism and nonendemic goiter, but its clinical and pathological heterogeneity opens the question if this disease should be more properly considered as a spectrum of different thyroid conditions rather than as a single nosological entity. In this study, we analysed 133 cases of HT for the expression of galectin-3, a lectin molecule involved in malignant transformation, apoptosis and cell cycle control. An unexpected expression of galectin-3 was demonstrated in a subset of HT together with the presence of HBME-1, c-met and cyclin-D1 that are also involved in malignant transformation and deregulated cell growth. Furthermore, a loss of allelic heterozygosity in a specific cancer-related chromosomal region was demonstrated in some HT harbouring galectin-3-positive follicular cells, by using laser capture microdissection. On the basis of the morphological and molecular findings we identified four subsets of HT: (a) HT with classic features of chronic autoimmune thyroiditis; (b) HT associated to hyperplastic/adenomatous lesions; (c) HT harbouring thyroid cancer precursors; (d) HT associated to unequivocal thyroid microcarcinomas. Our findings provide a well-substantiated morphological and molecular demonstration that HT may include a spectrum of different thyroid conditions ranging from chronic autoimmune thyroiditis to thyroiditis triggered by specific immune-response to cancer-related antigens.

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Auto-Antibodies in Hashimoto's Disease (Lymphadenoid Goitre)

Cited by 515 publications

References 4 publications

Down Syndrome and Thyroid Disorders: A Review

Down Syndrome and Thyroid Disorders: A Review

Thyroid peroxidase autoantibody epitopic ‘fingerprints’ in juvenile Hashimoto’s thyroiditis: evidence for conservation over time and in families

Detection and molecular characterisation of thyroid cancer precursor lesions in a specific subset of Hashimoto's thyroiditis

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