Auto-Disinfectant Acrylic Paints Functionalised with Triclosan and Isoborneol—Antibacterial Assessment

Querido, Micaela Machado; Paulo, Ivo; Hariharakrishnan, Sriram; Rocha, Daniel Guimarães Corrêa Moreira; Pereira, Cristiana; Barbosa, Nuno; Bordado, João Moura; Teixeira, João Paulo; Santos, Rui Galhano dos

doi:10.3390/polym13132197

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…The paints were prepared according to the procedure disclosed by Silva et al [ 50 ] and Querido et al [ 51 ]. Briefly, after the derivatization, the substances CLF and CUR were added to the commercial acrylic paint matrix (Velvet by Tintas Barbot).…”

Section: Methodsmentioning

confidence: 99%

Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin

Querido

Paulo²,

Hariharakrishnan³

et al. 2021

Antibiotics

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The risk of infection arising from indirect sources—namely, contaminated surfaces—has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted. In this work, wall-paints with self-disinfecting properties were developed with the scope of being applied in environments prone to contamination, such as those at healthcare settings. Our approach was to develop new paint formulations containing two natural plant-based products with known antimicrobial activity—colophony (CLF) and curcumin (CUR). The natural substances were separately incorporated on a commercial paint and their antibacterial activity was evaluated with several bacterial species following ISO 22196. To assess the paints’ safety, cytotoxicity tests were performed on HaCaT and A549 cell lines, using tests on extracts and direct contact tests, as suggested by the standardized protocol ISO 10993. In general, both paints containing CLF and CUR were able to reduce the bacterial growth after 24 h, compared with the control, the commercial unmodified paint. Colophony was even able to reduce the number of culturable bacteria by over 2 log for Staphylococcus aureus, Escherichia coli, and Bacillus cereus. Regarding the cytotoxicity tests performed (WST-1, NRU, and LDH), both formulations revealed promising results regardless of the methodology used.

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Section: Methodsmentioning

confidence: 99%

Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin

Querido

Paulo²,

Hariharakrishnan³

et al. 2021

Antibiotics

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“…The paints were prepared and characterized in the previous work by Querido et al [6]. The samples used in the tests by direct contact and on extracts were the unmodified commercial water-based paint (Un_Paint) and the self-disinfecting paints containing TCS in the concentration 0.0012 g/L and ISB in the concentration of 1.2 g/L applied in a 10 × 10 mm polymeric film square.…”

Section: Samples Preparationmentioning

confidence: 99%

“…This strategy allowed us to obtain self-disinfecting paints with antibacterial properties aiming to be applied in healthcare settings. The self-disinfecting paints, containing either triclosan (TCS) at 0.0012 g/L or isoborneol (ISB) at 1.2 g/L, two substances with known antimicrobial properties, proved their high antibacterial activity against Gram-positive and Gram-negative bacteria [6]. The published results demonstrate that both paints present potential to be applied as an effective strategy to prevent surface contamination.…”

Section: Introductionmentioning

confidence: 96%

In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol

Querido

Rosário

Bessa

et al. 2022

Toxics

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Surfaces with antimicrobial properties are gaining notoriety as an efficient method to avoid surface contamination. Self-disinfecting paints are a promising strategy towards cleaner indoor environments by preventing the colonization of walls with microorganisms. However, its widespread use needs an appropriate toxicological safety evaluation due to the potential for biological disturbance associated to its biocidal activity. In this work, the cyto- and genotoxic assessment of two self-disinfecting paints containing the antimicrobial substances triclosan (TCS) and isoborneol (ISB) is performed. HaCaT and A549 cell lines models were selected for the in vitro assessment. To evaluate the cytotoxicity, tests by direct contact and on extracts obtained from leaching were performed following ISO 10993, whereas the genotoxicity was assessed by comet assay and cytokinesis-block micronucleus (CBMN) assay. The results showed low levels of cyto- and genotoxicity under the models and conditions tested, indicating that these substances have commercial potential.

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Selected organic micropollutants in the aquatic environment

Włodarczyk-Makuła

2024

Desalination and Water Treatment

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Auto-Disinfectant Acrylic Paints Functionalised with Triclosan and Isoborneol—Antibacterial Assessment

Cited by 6 publications

References 20 publications

Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin

Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin

In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol

Selected organic micropollutants in the aquatic environment

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