Auto-immune hepatitis following COVID vaccination

Rela, Mohamed; Jothimani, Dinesh; Vij, Mukul; Rajakumar, Akila; Rammohan, Ashwin

doi:10.1016/j.jaut.2021.102688

Cited by 81 publications

(98 citation statements)

References 9 publications

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“…In the study by Rela et al [ 8 ] , two patients developed AIH after the AstraZeneca-ChAdOx1 nCoV-19 (AZD1222) vaccination. Both patients presented with liver profile alterations 2 weeks after the administration of the vaccine and further tests confirmed the diagnosis (i.e., liver biopsy: lymphocyte infiltration, multiacinar hepatic necrosis, periportal neocholangiolar proliferation).…”

Section: Discussionmentioning

confidence: 99%

“…Findings in liver biopsy correlate with reports of AIH following SARS-CoV-2 vaccination. Necroinflammatory hepatitis was observed in all cases of AIH following vaccination with Moderna mRNA-1273 COVID-19 [ [24] , [25] , [26] , [27] , [28] , [29] ], Pfizer-BioNTech mRNA vaccine [ [30] , [31] , [32] , [33] ], and AstraZeneca ChAdOx1 nCoV-19 vaccine [ 8 , 34 ]. It has been suggested that portal infiltration with eosinophils correlates with drug-induced liver injury, including vaccines (i.e., Moderna mRNA-1273 and AstraZeneca ChAdOx1 nCoV-19 vaccines) [ 8 , 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Necroinflammatory hepatitis was observed in all cases of AIH following vaccination with Moderna mRNA-1273 COVID-19 [ [24] , [25] , [26] , [27] , [28] , [29] ], Pfizer-BioNTech mRNA vaccine [ [30] , [31] , [32] , [33] ], and AstraZeneca ChAdOx1 nCoV-19 vaccine [ 8 , 34 ]. It has been suggested that portal infiltration with eosinophils correlates with drug-induced liver injury, including vaccines (i.e., Moderna mRNA-1273 and AstraZeneca ChAdOx1 nCoV-19 vaccines) [ 8 , 27 , 28 ]. This could partially explain the existence of hepatitis following vaccination without positivity for liver-associated autoantibodies ( Table 1 ) [ 8 , 10 , 12 , 13 , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] ].…”

Section: Discussionmentioning

confidence: 99%

“…COVID-19 vaccination has been broadly associated with diverse autoimmune conditions. These include autoimmune hepatitis (AIH) [ 8 ], myocarditis [ 9 , 10 ], immune thrombotic thrombocytopenia [ 11 ], Guillain-Barré syndrome [ 12 ], and giant cell arteritis [ 13 ]. Interestingly, patients with autoimmune diseases (ADs) prior to vaccination may exhibit flares following the administration of the biologic [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

COVID-19 vaccine and autoimmunity. A new case of autoimmune hepatitis and review of the literature

Camacho-Domínguez

Rodríguez

Polo

et al. 2022

Journal of Translational Autoimmunity

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Autoimmunity following COVID-19 vaccination has been reported. Herein, a 79-year-old man with clinical and immunological features of autoimmune hepatitis type 1 after ChAdOx1 nCoV-19 vaccination is presented. Clinical manifestations rapidly remitted after the instauration of immunomodulatory management. This case, together with a comprehensive review of the literature, illustrates the association between COVID-19 vaccines and the development of autoimmune conditions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

COVID-19 vaccine and autoimmunity. A new case of autoimmune hepatitis and review of the literature

Camacho-Domínguez

Rodríguez

Polo

et al. 2022

Journal of Translational Autoimmunity

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“…At follow-up one month later, she remained well and asymptomatic. ( Cines and Bussel, 2021 ; Rela et al, 2021 ; Oxford Martin School UoO, 2021 )…”

Section: Case Presentationmentioning

confidence: 99%

Aseptic meningitis after BNT-162b2 COVID-19 vaccination

Chan

Tan

Goh

et al. 2022

Brain, Behavior, & Immunity - Health

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The COVID-19 pandemic has had an unprecedented impact on healthcare systems globally, giving rise to significant morbidity and mortality. Vaccination has been widely regarded as the most important strategy to contain the pandemic. Whilst local side-effects of the BNT-162b1 (Pfizer-BioNTech) vaccine are well known, concern has emerged due to sporadic reports of immune-mediated adverse effects (Cines and Bussel, 2021; Rela et al., 2021). As of August 19, 2021, 4.54 million individuals had received COVID-19 vaccines in Singapore (Oxford Martin School UoO, 2021). We report a case series of two patients who developed aseptic meningitis after vaccination.

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COVID‐19 vaccine‐associated myositis – a case report

Bose¹,

Goenka²,

Moitra³

et al. 2022

Clinical Case Reports

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Myositis is one of the uncommon adverse events following COVID‐19 vaccination, and its mechanism is still unclear. A strong clinical suspicion and further evaluation are important not only for early diagnosis and management but also for better understanding of the unprecedented effects of this novel vaccine. We present a case of myositis following the first dose of the ChAdOx1 nCoV‐19 Corona Virus Vaccine, evidenced by serology and MRI.

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Auto-immune hepatitis following COVID vaccination

Cited by 81 publications

References 9 publications

COVID-19 vaccine and autoimmunity. A new case of autoimmune hepatitis and review of the literature

COVID-19 vaccine and autoimmunity. A new case of autoimmune hepatitis and review of the literature

Aseptic meningitis after BNT-162b2 COVID-19 vaccination

COVID‐19 vaccine‐associated myositis – a case report

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