This chapter first introduces the research on next-generation care systems and stations that the author’s group has actually conducted. Next, the development trends, challenges, and prospects for smart hospitals, which aim to improve overall hospital efficiency based on CPS technologies such as sensing, IoT, AI, and big data processing, in addition to robotics and control technologies, toward the realization of Society 5.0, are described. Third, the concept of the smart hospital and discussion will be explained to provide basic knowledge for its construction. Finally, future scope and conclusion will be described.