Autoamplification of Notch Signaling in Macrophages by TLR-Induced and RBP-J–Dependent Induction of Jagged1

Foldi, Julia; Chung, Andy; Xu, Haixia; Zhu, Jimmy; Outtz, Hasina H.; Kitajewski, Jan; Li, Yueming; Hu, Xiaoyu; Ivashkiv, Lionel B.

doi:10.4049/jimmunol.1001544

Cited by 113 publications

(119 citation statements)

References 56 publications

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“…A recent study by Foldi et al demonstrated that stimulation with TLR agonists led to upregulation of the Notch ligand Jagged1, which is mediated by NF-kB. 16 The authors suggested that this event initiates the Notch signaling cascade during a pro-inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

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Direct regulation of interleukin-6 expression by Notch signaling in macrophages

2011

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Section: Discussionmentioning

confidence: 99%

“…Notch signaling is reported to activate the NF-kB pathway, and in turn, the NF-kB pathway sustains the activation of Notch signaling via the induction of Notch ligands. 16,18,19 In addition, Notch and NF-kB may cooperatively bind Notch signaling partially regulates IL-6 expression in macrophages W Wongchana and T Palaga 160…”

Section: Discussionmentioning

confidence: 99%

Direct regulation of interleukin-6 expression by Notch signaling in macrophages

2011

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“…22,23 Activation of Notch signaling regulates proinflammatory responses. 22,24 Furthermore, it has been reported that in macrophages infected with Bacillus Calmette-Guérin (BCG), Notch1 is upregulated and SOCS3 expression is induced. 25 Mycobacterial infection also induces the expression of dll4, a Notch ligand, via TLR9 and promotes TH17 activity during granuloma formation.…”

Section: Introductionmentioning

confidence: 99%

Notch signaling regulates expression of Mcl-1 and apoptosis in PPD-treated macrophages

et al. 2013

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“…Among the nine gene-signatures found by our new method (JAG1, MET, CDH5, ABCC3, DSP, ABCD3, PECAM1, MAPRE2 and PDF5), proteins encoded by some of these gene-signatures (e.g., JAG1 and MAPRE2) have been showed to involve in the signal transduction of cells and proliferation control of normal cells [18]. It has also been found that MAPRE2 is highly expressed in pancreatic cancer cells, and seems to be involved in perineural invasion [19].…”

Section: Introductionmentioning

confidence: 99%

A novel method for finding non-small cell lung cancer diagnosis biomarkers

Tran

2013

BMC Med Genomics

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BackgroundOne of the most common causes of worldwide cancer premature death is non-small cell lung carcinoma (NSCLC) with a very low survival rate of 8%-15%. Since patients with an early stage diagnosis can have up to four times the survival rate, discovering cost-effective biological markers that can be used to improve the diagnosis and prognosis of the disease is an important clinical challenge.In the last few years, significant progress has been made to address this challenge with identified biomarkers ranging from 5-gene signatures to 133-gene signatures. However, A typical molecular sub-classification method for lung carcinomas would have a low predictive accuracy of 68%-71% because datasets of gene-expression profiles typically have tens of thousands of genes for just few hundreds of patients. This type of datasets create many technical challenges impacting the accuracy of the diagnostic prediction.ResultsWe discovered that a small set of nine gene-signatures (JAG1, MET, CDH5, ABCC3, DSP, ABCD3, PECAM1, MAPRE2 and PDF5) from the dataset of 12,600 gene-expression profiles of NSCLC acts like an inference basis for NSCLC lung carcinoma and hence can be used as genetic markers. This very small and previously unknown set of biological markers gives an almost perfect predictive accuracy (99.75%) for the diagnosis of the disease the sub-type of cancer. Furthermore, we present a novel method that finds genetic markers for sub-classification of NSCLC. We use generalized Lorenz curves and Gini ratios to overcome many challenges arose from datasets of gene-expression profiles. Our method discovers novel genetic changes that occur in lung tumors using gene-expression profiles.ConclusionsWhile proteins encoded by some of these gene-signatures (e.g., JAG1 and MAPRE2) have been showed to involve in the signal transduction of cells and proliferation control of normal cells, specific functions of proteins encoded by other gene-signatures have not yet been determined. Hence, this work opens new questions for structural and molecular biologists about the role of these gene-signatures for the disease.

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Autoamplification of Notch Signaling in Macrophages by TLR-Induced and RBP-J–Dependent Induction of Jagged1

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Cited by 113 publications

References 56 publications

Direct regulation of interleukin-6 expression by Notch signaling in macrophages

Direct regulation of interleukin-6 expression by Notch signaling in macrophages

Notch signaling regulates expression of Mcl-1 and apoptosis in PPD-treated macrophages

A novel method for finding non-small cell lung cancer diagnosis biomarkers

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