Autoantibodies against CD28 are associated with atopic diseases

Neuber, Karsten; Mähnß, Birgit; Hübner, Carlos von Krakauer; Gergely, H.; Weichenthal, Michael

doi:10.1111/j.1365-2249.2006.03218.x

Cited by 15 publications

(10 citation statements)

References 41 publications

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“…It is also known that autoantibody against α-enolase is involved in autoimmune disease [19]. Many previous studies have shown that sera of patients with severe AD contain autoantibody specific for self-proteins, supporting the hypothesis of autoreactivity as a pathogenic factor in AD [20, 21]. Thus, it also seems possible that α-enolase is involved in the pathogenesis of AD as an autoreactive factor.…”

Section: Discussionmentioning

confidence: 94%

New Horny Layer Marker Proteins for Evaluating Skin Condition in Atopic Dermatitis

Yamane

Moriyama²,

Yasuda³

et al. 2009

Int Arch Allergy Immunol

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Background: Atopic dermatitis (AD) has a complicated pathogenesis and its clinical features vary greatly among patients. Although many clinical parameters have been reported, it remains difficult to evaluate AD skin conditions adequately. Objective: To support better evaluation of AD patients, we attempted to develop a new, objective and noninvasive method that assesses skin condition in AD using biochemical markers in the skin’s horny layer (HL). Methods: Thirty-six patients with AD, 8 with psoriasis and 16 healthy volunteers were recruited. HL samples were obtained by tape stripping from involved and uninvolved skin of the forearms. Expression levels of 6 proteins in the HL [fatty acid-binding protein-5 (FABP-5), squamous cell carcinoma antigens 2 (SCCA2), α-enolase, annexin II, apolipoprotein A-I and albumin] were analyzed by immunoblotting and compared with clinical data. Results: The 6 proteins were detected at a high level in AD skin lesions, but scarcely in the normal controls. FABP-5 showed correlation with the local severity of the involved skin. Annexin II, apoprotein A-I and albumin showed correlation with the severity of specific eruptions. SCCA2 correlated significantly with total serum IgE level. Albumin levels in the uninvolved skin of AD patients showed significant correlation with the local severity in the involved skin of the same patient and with the trans-epidermal water loss. Albumin levels in psoriatic skin were very low, even with scratch marks, compared to those in AD skin. Conclusion: FABP-5, albumin and some other proteins in HL seem to be useful as biomarkers to evaluate inflammation and skin barrier conditions in AD patients.

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Section: Discussionmentioning

confidence: 94%

New Horny Layer Marker Proteins for Evaluating Skin Condition in Atopic Dermatitis

Yamane

Moriyama²,

Yasuda³

et al. 2009

Int Arch Allergy Immunol

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“…In addition to immunologic sensitization to chemicals, both intrinsic asthma (Nahm et al 2002) and asthma caused by diisocyanate exposure are associated with antibodies directed to epithelial components (Ye et al 2006a). Other autoantibodies in asthma include those directed to heatshock protein (HSP)-70 (Yang et al 2005), CD28 (Neuber et al 2006), and a-enolase (Nahm et al 2006). Whether such autoantibodies are truly pathogenetic or related more to tissue damage and inflammation remains to be established (Ye et al 2006b).…”

Section: Nonallergic (Late-onset or Intrinsic) Asthmamentioning

confidence: 99%

Pathogenesis of Asthma

Holgate¹

2008

Clin Experimental Allergy

692

486

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While asthma is considered an inflammatory disorder of the conducting airways, it is becoming increasingly apparent that the disease is heterogeneous with respect to immunopathology, clinical phenotypes, response to therapies, and natural history. Once considered purely an allergic disorder dominated by Th2-type lymphocytes, IgE, mast cells, eosinophils, macrophages, and cytokines, the disease also involves local epithelial, mesenchymal, vascular and neurologic events that are involved in directing the Th2 phenotype to the lung and through aberrant injury-repair mechanisms to remodeling of the airway wall. Structural cells provide the necessary "soil" upon which the "seeds" of the inflammatory response are able to take root and maintain a chronic phenotype and upon which are superimposed acute and subacute episodes usually driven by environmental factors such as exposure to allergens, microorganisms, pollutants or caused by inadequate antiinflammatory treatment. Greater consideration of additional immunologic and inflammatory pathways are revealing new ways of intervening in the prevention and treatment of the disease. Thus increased focus on environmental factors beyond allergic exposure (such as virus infection, air pollution, and diet) are identifying targets in structural as well as immune and inflammatory cells at which to direct new interventions.

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“…19 Autoantibodies against CD28 were found stimulate T cells and overcome the CD152-Ig-induced anergy of T cells in an mixed lymphocyte reaction. 20 The function of autoantibodied to CD80 need to be clarified.…”

Section: Discussionmentioning

confidence: 99%

Autoantibodies against CD80 in patients with COPD

et al. 2016

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Chronic obstructive pulmonary disease (COPD) is an inflammation disorder and possibly an autoimmune disease. The components of the autoimmune response in the circulatory system are of considerable interest to clinicians. Because aberrations of costimulation status have been noted in COPD, the presence of autoantibodies to B7 costimulatory factor CD80 were investigated in a cohort of patients. Recombinant rs1CD80 (lacking the transmembrane domain of CD80) was used for Western blot analysis and ELISA to investigate the presence of autoantibodies in sera of patients with stable COPD and in controls without COPD. Cytokines IL-6 and IL-8 were detected using ELISA. Western blot revealed a specific band reacting to rs1CD80 by diluting sera pool of patients, which indicated the existence of autoantibodies to CD80. The serum level of anti-rs1CD80 was higher in patients with COPD than in controls(P=0.0185) and was positively correlated to the serum level of IL-6 (r=0.797, P<0.001) and IL-8 (r=0.608, P<0.001). There was a tendency that more higher level of anti-rs1CD80, more severe COPD stage. The existence of autoantibodies to costimulatory factor CD80 may suggest a pathogenic role of costimulatory factors in COPD.

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Autoantibodies against CD28 are associated with atopic diseases

Cited by 15 publications

References 41 publications

New Horny Layer Marker Proteins for Evaluating Skin Condition in Atopic Dermatitis

New Horny Layer Marker Proteins for Evaluating Skin Condition in Atopic Dermatitis

Pathogenesis of Asthma

Autoantibodies against CD80 in patients with COPD

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