Autoantibodies against complement C1q correlate with the thyroid function in patients with autoimmune thyroid disease

Potluková, Eliška; Jiskra, Jan; Límanová, Z; Sandova, Petra; Smutek, Daniel; Marecková, H; Schneider, Brigitte; Antošová, Marie; Trendelenburg, Marten

doi:10.1016/j.molimm.2007.06.079

Cited by 5 publications

(9 citation statements)

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“…This is comprehensible, as C1q and anti-C1q are linked to immune-complex-mediated disorders. However, the recent preliminary findings of our group suggest that anti-C1q antibodies might be associated with autoimmune thyroid diseases as typical representatives of organspecific autoimmune disorders [35]. We have found an increased prevalence of anti-C1q antibodies in patients with Graves' disease (7 ⁄ 23 patients; 30%) and Hashimoto's thyroiditis (11 ⁄ 52 patients; 21%) in comparison with healthy controls (6 ⁄ 72 controls; 8%) and patients with non-autoimmune thyroid disorders (1 ⁄ 21; 5%).…”

Section: Anti-c1q Antibodies In Organ-specific Autoimmune Diseasesmentioning

confidence: 86%

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Complement Component C1q and Anti‐C1q Antibodies in Theory and in Clinical Practice

Potluková

Králíková

2008

Scand J Immunol

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The complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti‐C1q) have been found in a number of autoimmune and infectious diseases. They have been best described in patients with systemic lupus erythematosus, where they are thought to play a pathogenic role in lupus nephritis (LN). Their high negative predictive value for the occurrence of active proliferative LN, as well as their possible ability to indicate a renal flare as soon as 6 months in advance, have rendered anti‐C1q antibodies a novel non‐invasive tool in the detection of active LN.

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Section: Anti-c1q Antibodies In Organ-specific Autoimmune Diseasesmentioning

confidence: 86%

“…Anti-C1q antibodies were mostly of the IgG subtype with IgG1 and IgG2 being the predominant subclasses [29,32,33]. The prevalence of anti-C1q in the general population varies between 2% and 8% [21,28,29,[33][34][35]. As is the case with other autoantibodies, the occurrence of anti-C1q increases with age.…”

Section: Immune Complexmentioning

confidence: 99%

Complement Component C1q and Anti‐C1q Antibodies in Theory and in Clinical Practice

Potluková

Králíková

2008

Scand J Immunol

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“…In our study we could show that 36Á7% of pregnant TPOAb-positive women were also positive for anti-C1q, in contrast to only 17Á5% of pregnant controls without AITD. However, anti-C1q positivity in AITD-negative pregnant women were still significantly higher than in the group of blood donors (8%), and similar to the 21% anti-C1q positivity in non-pregnant women with AITD [21]. Thus, it seems that pregnancy per se has a strong effect on anti-C1q levels both in women with and without AITD.…”

Section: Discussionmentioning

confidence: 56%

“…However, their role in organ-specific autoimmune diseases is less clear. Previously, we have shown that patients with autoimmune thyroid diseases (AITD) are more frequently positive for anti-C1q, and that anti-C1q levels correlate with thyroid dysfunction both in Hashimoto's thyroiditis (HT) and Graves' disease (GD) [21]. Although it seems that alterations in C1q and/or anti-C1q levels during pregnancy might be associated with adverse pregnancy outcome (spontaneous abortions and extrauterine gravidity) [22], the prevalence and clinical value of anti-C1q in pregnancyassociated AITD remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Anti-C1q autoantibodies are linked to autoimmune thyroid disorders in pregnant women

Vítková

Jiskra

Springer

et al. 2016

Clinical and Experimental Immunology

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Anti-C1q antibodies (anti-C1q) have been implicated in the pathogenesis of autoimmune diseases, including autoimmune thyroid disorders (AITD). The aim of this study was to evaluate the association between anti-C1q and thyroid function in pregnancy-associated AITD. In 96 pregnant women screened positive for AITD (thyroid dysfunction and/or antibodies against thyroperoxidase - TPOAb), anti-C1q were measured during the 9-11th gestational week and after delivery (median 16 months after delivery), and compared to the corresponding serum levels of thyroid hormones. As controls, 80 healthy pregnant women, 72 non-pregnant AITD patients and 72 blood donors were included. In the non-pregnant AITD group, two serum samples ≥ 6 months apart were analysed. Compared to blood donors, anti-C1q levels were substantially higher in all pregnant women analysed. In pregnancy, anti-C1q levels were higher in the TPOAb-positive women than in controls (37 versus 17·5%, P < 0·0001). Anti-C1q-positive pregnant women screened positive for AITD had higher thyroid-stimulating hormone (TSH) levels than anti-C1q-negative women (2·41 versus 1·94 mU/l, P = 0·01), and TSH correlated positively with anti-C1q (r = 0·226, P = 0·045) in the TPOAb-positive women. After delivery, serum levels of anti-C1q decreased in the positively screened TPOAb-negative women (8·8 versus 5·9 U/l, P = 0·002), but not in the TPOAb-positive ones, and they no longer correlated with TSH. Anti-C1q antibody levels increase during pregnancy in general and even more in the context of AITD, where they correlate with thyroid stimulating hormone levels.

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“…Potlukova and cols. reported that auto-antibodies against C1q are more prevalent in AITD patients compared with controls (27), while Brohee and cols. reported that circulating immune complexes containing C1q are also more prevalent in AITD patients than controls (28).…”

Section: Discussionmentioning

confidence: 93%

Association between C1q gene polymorphisms and autoimmune thyroid diseases

Yao

et al. 2017

Arch. Endocrinol. Metab.

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Objective: In the present study, we aimed to assess the associations of C1q gene polymorphisms with autoimmune thyroid diseases (AITD) susceptibility. Subjects and methods: A set of 1,003 AITD patients (661 with Graves' disease and 342 with Hashimoto's thyroiditis) and 880 ethnicallyand geographically-matched controls from Chinese Han population were included. Five common single nucleotide polymorphisms (SNPs) (rs294185, rs292001, rs682658, rs665691 and rs294179) in C1q gene locus were genotyped. Frequencies of genotypes and alleles were compared between patients and controls, and haplotype analysis was also performed. Results: There was no statistically significant difference between AITD patients and controls in the frequencies of alleles of rs294185 (P = 0.41), rs292001 (P = 0.71), rs682658 (P = 0.68), rs665691 (P = 0.68) and rs294179 (P = 0.69). There was also no statistically significant difference between AITD patients and controls in the frequencies of genotypes of rs294185 (P = 0.72), rs292001 (P = 0.89), rs682658 (P = 0.83), rs665691 (P = 0.90) and rs294179 (P = 0.43). Stratified analyses showed that none of those five SNPs in C1q gene were associated with Graves' disease or Hashimoto's thyroiditis (all P values > 0.05). Haplotype analysis revealed that there were no obvious genetic associations of C1q gene polymorphisms with AITD susceptibility. Conclusions: We, for the first time, identified the associations between C1q gene SNPs and AITD, and our findings suggested that five common SNPs in C1q gene were not associated with AITD susceptibility in Chinese Han population. Arch Endocrinol Metab. 2017;61(3):337-42.

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Autoantibodies against complement C1q correlate with the thyroid function in patients with autoimmune thyroid disease

Cited by 5 publications

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Complement Component C1q and Anti‐C1q Antibodies in Theory and in Clinical Practice

Complement Component C1q and Anti‐C1q Antibodies in Theory and in Clinical Practice

Anti-C1q autoantibodies are linked to autoimmune thyroid disorders in pregnant women

Association between C1q gene polymorphisms and autoimmune thyroid diseases

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