Autoantibodies against Oxidized LDL in the First Phase of Life

Abstract

The study presents a comparison of data concerning lipid metabolism and lipid oxidation (oxidative stress) in children at the time of their birth and 3 months later, as well as of their mothers at the time of delivery, compared to a control group of non-pregnant women of the same age. The data confirm that labour represents an oxidative stress for both mother and child; it is expressed as a significant increase of malondialdehyde concentration in mothers immediately after delivery in comparison with non-pregnant women (p<0.001). Its concentration in newborns was even higher than in their mothers (p<0.005). Concentration of antibodies against oxidized LDL (oxLDLAb) was comparable in mothers and newborns due to their transplacental transport. During the first three months of life these autoantibodies increased almost two-fold. The importance of this unique observation is discussed with respect to possible early atherogenesis.

Oxidative stress in small-for-gestational age (SGA) term newborns and their mothers

“…Steinerova et al [18] found a significantly higher peroxide level in mothers after delivery, while Rogers et al [16] found lower peroxides levels in cord blood. Thus, our findings confirm both these studies.…”

Relationship of Oxidized Phospholipids and Biomarkers of Oxidized Low-Density Lipoprotein With Cardiovascular Risk Factors, Inflammatory Biomarkers, and Effect of Statin Therapy in Patients With Acute Coronary Syndromes

“…4) They display an acute phase response in acutely ill patients, often increasing significantly within hours to days after an event. 5) They may have different influences on atherogenesis, at least in experimental models, in which IgMs, which are more likely to be enriched in natural antibodies present even at birth (26) seem to be atheroprotective, but IgGs seem to be atherogenic, except perhaps in response to vaccination, in which they may be associated with atheroprotection (10,26,34,35,(37)(38)(39). In humans, we have recently shown that IgM OxLDL autoantibodies and IgM apoB-ICs were associated inversely with the presence of angiographically determined CAD, whereas IgG OxLDL autoantibodies and IgG apoB-ICs were positively associated (40).…”

Antiphospholipid antibodies: Paradigm in transition

“…The investigators found that anti-oxLDL IgA correlated closely with aCL (p < 0.0001) but IgM and IgG had weak or no association, respectively. Steinerova et al [148] measured anti-oxPL in infants and observed that breast-fed babies, during the first 3 months, had much lower levels (p < 0.001) and less DNA breaks than those not breast-fed. As noted later, CL easily oxidizes in air so that many reports actually measure aOxCL, not aCL.…”