Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome

Rodríguez‐Bayona, Beatriz; Ruchaud, Sandrine; Rodrı́guez, Carmen; Linares, Mario Alfredo; Astola, Antonio; Ortiz, Manuela; Earnshaw, William C.; Valdivia, Manuel M.

doi:10.1186/1740-2557-4-1

Cited by 16 publications

(4 citation statements)

References 16 publications

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“…Recently, the presence of autoantibodies to centromere passenger INCENP has been documented [ 5 ]. This protein is a major component of the centromere during several phases of the mitotic cell cycle, where it plays an essential role in chromosome segregation and participates in the mechanisms regulating mitosis [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical, Dermoscopic and In-Vivo Reflectance Confocal Microscopy Evaluation of a Case of Graham Little-Piccardi-Lassueur Syndrome Successfully Treated with Narrowband-UVB Phototherapy

Arisi

Gelmetti

Zanca

et al. 2020

Dermatol Ther (Heidelb)

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Graham Little-Piccardi-Lassueur syndrome (GLPLS) is a rare variant of lichen planopilaris, characterized by a triad of clinical signs including follicular spinous papules on the body area, scarring alopecia of the scalp and non-scarring alopecia of the groin and/or axilla. To date, fewer than 50 cases have been described in the literature. We first report a case of GLPLS investigated with non-invasive techniques such as dermoscopy and in vivo reflectance confocal microscopy (RCM) and successfully treated with narrowband-UVB (NB-UVB) phototherapy.

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Section: Discussionmentioning

confidence: 99%

Clinical, Dermoscopic and In-Vivo Reflectance Confocal Microscopy Evaluation of a Case of Graham Little-Piccardi-Lassueur Syndrome Successfully Treated with Narrowband-UVB Phototherapy

Arisi

Gelmetti

Zanca

et al. 2020

Dermatol Ther (Heidelb)

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“…Rodríguez-Bayona B et al proposed an autoimmune theory of the disease and stated that the major autoantigen in a GLPL syndrome patient was INCENP protein [20]. INCENP is a major component of the centromere during several phases of the mitotic cell cycle where it plays an essential role in chromosome segregation and participates in the mechanisms regulating mitosis [21].…”

Section: Discussionmentioning

confidence: 99%

Graham-Little-Piccardi-Lassueur Syndrome: Two Case Reports and Review of the Literature

Dourmishev

Mironova

Popov

et al. 2020

Acta Medica Bulgarica

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Graham-Little-Piccardi-Lassueur syndrome (GLPLS) is a rare syndrome characterized by the triad of cicatricial alopecia of the scalp, non-cicatricial alopecia of the axilla and groin and follicular lichen planus eruptions on the trunk and extremities. GLPLS is considered to be a variant of lichen planopilaris. We report two cases that have fulfilled all of the criteria for GLPLS. The first case was a 71-year-old woman, admitted to the Department of Dermatology for pruritic perifollicullar erythema and scaling of the scalp, cicatricial scalp alopecia and hair loss of the axilla and pubic region for five months. Subsequently, follicular hyperkeratotic eruptions and hyperpigmented macules on the skin of the chest and abdomen appeared. The second case was a 48-year-old man with pruritic follicular papules on the face, trunk and extremities for four months. All of the laboratory examinations in both patients were within normal limits. No alternation in the general condition of the patients was observed. Histological examinations in both patients confirmed the diagnosis GLPLS. The patients were treated with systemic and local corticosteroid resulting in marked improvement of the skin lesions; however, cicatricial scalp alopecia showed no response to the treatment.

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“…Although its pathogenic mechanism remains unclear, following the description of the first antibody against the INCENP protein (a major component of the centromere during several phases of the mitotic cell cycle ) , an autoimmune etiology was more recently proposed.This protein is considered to be one of the main antigens in this syndrome. 9 …”

Section: Discussionmentioning

confidence: 99%

Piccardi-Lassueur-Graham-Little syndrome associated with frontal fibrosing alopecia

Griffiths

Sancho

Plaza

2017

An. Bras. Dermatol.

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Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome

Cited by 16 publications

References 16 publications

Clinical, Dermoscopic and In-Vivo Reflectance Confocal Microscopy Evaluation of a Case of Graham Little-Piccardi-Lassueur Syndrome Successfully Treated with Narrowband-UVB Phototherapy

Clinical, Dermoscopic and In-Vivo Reflectance Confocal Microscopy Evaluation of a Case of Graham Little-Piccardi-Lassueur Syndrome Successfully Treated with Narrowband-UVB Phototherapy

Graham-Little-Piccardi-Lassueur Syndrome: Two Case Reports and Review of the Literature

Piccardi-Lassueur-Graham-Little syndrome associated with frontal fibrosing alopecia

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