Autoantibodies as putative biomarkers and triggers of cell dysfunctions in systemic sclerosis
Irene Rosa,
Eloisa Romano,
Bianca Saveria Fioretto
et al.
Abstract:Purpose of review
Antinuclear autoantibodies represent a serological hallmark of systemic sclerosis (SSc), with anticentromere, antitopoisomerase-I, and anti-RNA polymerase III antibodies routinely assessed for diagnosis, clinical subset classification, and prognosis. In addition, an increasing number of autoantibodies have been demonstrated to play a pathogenic role by mediating different SSc manifestations. This review aims to give an overview on autoantibodies as putative biomarkers in SSc and d… Show more
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