Autoantibodies in Chinese patients with chronic hepatitis B: Prevalence and clinical associations

Abstract

ANA-H could be an indicator of early-stage CHB. Dichotomizing the autoantibody profiles revealed that the PBC profile is strongly associated with cirrhosis in CHB.

Anti‐ENA antibody profiles in patients with hepatitis C virus infection

“…Four of the positive IFA samples showed a cytoplasmic IFA pattern. Increased rates of ANA positivity with cytoplasmic pattern on IFA have been previously reported for hepatitis infections, including hepatitis A and hepatitis B . In summary, our study emphasizes the relatively high prevalence of anti‐ENA antibodies in HCV antibody‐positive patients when compared to healthy controls.…”

A Young Man with Non-alcoholic Steatohepatitis and Serum Anti-mitochondrial Antibody Positivity

“…In patients with PBC, which is characterized histologically by bile duct lesions and chronic cholangitis, AMA positivity (a diagnostic criterion of PBC) is present in around 95% of patients ( 9 ). In contrast, in non-PBC patients, the frequency of AMA positivity in the general population is 0.64% ( 10 ), whereas that in patients with liver injury [chronic hepatitis B ( 11 , 12 ), chronic hepatitis C ( 13 ), autoimmune hepatitis ( 14 ), non-alcoholic fatty liver disease (NAFLD) ( 4 - 7 ), and acute liver failure ( 15 )] is even higher ( Table 2 ). Therefore, in non-PBC patients with factors predisposing them to eventually develop PBC, liver injury might trigger AMA production or contribute to the manifestation of AMAs below detection sensitivity.…”

Subtle presentation of active primary biliary cirrhosis in chronic hepatitis B: a case report

“…In a recently published study in China, Bo-An Li et al . reported presence of the AMA-M2 antibody in 22 of 325 (6.8%) patients with chronic hepatitis B [ 10 ].…”