Autoantibodies in Connective Tissue Diseases. Clinical Significance and Analysis of Target Autoantigens.

Mimori, Tsuneyo

doi:10.2169/internalmedicine.38.523

Cited by 25 publications

(15 citation statements)

References 86 publications

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“…It is a member of group D SOX-proteins [6] and is ubiquitously expressed in human tissues with highest expressions in pancreas, placenta and kidney [5]. Because autoantibodies against proteins associated with DNA replication and transcription are well known to be present in patients with rheumatic diseases [7], we decided that sera from those patients could serve as optimal controls to determine the specificity of SOX-13Ab. We observed SOX-13Ab in 4.0±11.4 % of those patients which clearly shows their non-diabetes specific nature.…”

Section: Discussionmentioning

confidence: 99%

Autoantibodies to ICA12 (SOX-13) are not specific for Type I diabetes

et al. 2000

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Section: Discussionmentioning

confidence: 99%

Autoantibodies to ICA12 (SOX-13) are not specific for Type I diabetes

et al. 2000

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“…These include antibodies reactive with nuclear antigens, membrane proteins, cytoplasmic proteins, and secreted products. Many autoantigens are intracellular enzymes and regulatory factors required for cellular function, especially gene replication, transcription, RNA processing, and protein synthesis 121. Interestingly, these molecules have little in common in terms of structure, subcellular localization, or biological function.…”

Section: Etiology Of Sjogren Syndrome and Sjogren Syndrome-like DImentioning

confidence: 99%

Unraveling the Pathophysiology of Sjogren Syndrome-Associated Dry Eye Disease

2009

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Sjogren syndrome (SS) is one of the most common autoimmune diseases. Early clinical manifestations of SS are primarily decreased tear and saliva secretion, leading to dry eye and dry mouth syndromes, but in its later stages, it can become systemic, even resulting in B cell lymphomas. The use of new animal models, coupled with new technologies, is providing exciting insights into the pathogenesis, genetic predisposition, and, possibly, early diagnosis of SS. This article reviews newly described features of SS identified in experimental animal models and their relationship to human disease. New technologies, such as genomics and proteomics, may permit identification of potential candidate genes and biomarkers for disease diagnosis. Current studies using appropriate animal models in parallel with studies of human subjects is rapidly establishing a foundation for new intervention strategies that go beyond merely treating symptoms.

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“…Other associated autoantibodies include anti-DNA protein kinase complex antibodies and anti-U2 RNP antibodies, rare antibodies that usually coexist with anti-U1 RNP. 8 The aetiology and pathogenic mechanisms of PM-Scl overlap remain unknown. A strong association of anti-PM-Scl antibody with HLA DR3 and an increased frequency of HLA DQA*0501 suggest a genetic influence.…”

Section: Scleroderma-polymyositis Overlap Syndrome (Pm-scl)mentioning

confidence: 99%

Autoantibodies and overlap syndromes in autoimmune rheumatic disease

Jury¹

2001

Journal of Clinical Pathology

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Many patients diagnosed with autoimmune rheumatic disease cannot be categorised easily into one of the established clinical entities such as systemic lupus erythematosus, dermatomyositis, or systemic sclerosis. The term "overlap syndrome" has been increasingly used to identify such patients and is useful in terms of clarifying prognosis and facilitating disease management. This article reviews overlap syndrome in autoimmune rheumatic disease, with particular emphasis on the associated serological markers. (J Clin Pathol 2001;54:340-347)

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Autoantibodies in Connective Tissue Diseases. Clinical Significance and Analysis of Target Autoantigens.

Cited by 25 publications

References 86 publications

Autoantibodies to ICA12 (SOX-13) are not specific for Type I diabetes

Autoantibodies to ICA12 (SOX-13) are not specific for Type I diabetes

Unraveling the Pathophysiology of Sjogren Syndrome-Associated Dry Eye Disease

Autoantibodies and overlap syndromes in autoimmune rheumatic disease

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