Autoantibodies in early breast cancer: a stage-related phenomenon?

Turnbull, A. R.; Turner, DP; Fraser, James D.; Lloyd, R. S.; Láng, Cs.; Wright, Ralph

doi:10.1038/bjc.1978.230

Cited by 29 publications

(8 citation statements)

References 9 publications

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“…It has been shown that immune response to autoantigens seen in patients with limited tumors prolonged survival or tumor regression 28, 29, 30, 31. Conversely, the presence of anti‐nuclear and anti‐smooth muscle in patients with breast carcinoma was associated with poor prognosis 32, 33. Furthermore, autoantibodies that inhibit tumor cell apoptosis have been identified in several malignancies, indicating an important functional effect of these autoantibodies on tumor behavior 34.…”

Section: Discussionmentioning

confidence: 99%

Autoantibodies to tubulin are specifically associated with the young age onset of the nasopharyngeal carcinoma

Jalbout

Jrad

Bouaouina

et al. 2002

Intl Journal of Cancer

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By far the highest incidence of the Epstein-Barr virus (EBV)-associated nasopharyngeal carcinomas in young subjects was found in North Africa, a region of intermediate risk for adults. We used the immunofluorescence analysis and ELISA to characterize the presence of IgG autoantibodies to the cytoskeleton and nuclear proteins in sera of 82 Tunisian patients with primary nasopharyngeal carcinoma and those of 82 healthy subjects. To assess the specificity of the sera autoreactivity, inhibition tests were carried out using free autoantigens. Analysis of sera autoreactivity in patients with nasopharyngeal carcinoma and in control subjects showed that 23% of the patients had serum reactivity against more than 1 autoantigen tested compared to 1.2% in the control group (p ‫؍‬ 10 ؊4 ). The most frequent auto reactivity in patient's sera was found with tubulin and nuclear proteins (19.5% and 22% respectively vs. 6.1% and 1.2% in controls). The IgG auto reactivity inhibition studies indicate that all autoantigens, except native DNA, showed low values of IC 50 (concentration of antigen causing 50% inhibition of the antibody binding) reflecting the high affinity of these IgG autoantibodies. When patients and controls were stratified according to their age, IgG autoantibodies to tubulin were found specifically associated with the young age onset of the nasopharyngeal carcinoma (age under 25 years). IgG auto reactivity comparison before and after cancer therapy showed that only anti-tubulin reactivity was significantly affected by treatment. Our results demonstrate that the autoantibodies to the cytoskeleton and nuclear proteins are associated with the nasopharyngeal carcinoma in Tunisians. The anti-tubulin IgG autoantibodies may represent a serologic marker for the nasopharyngeal carcinoma in children and adolescents Tunisians.

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Section: Discussionmentioning

confidence: 99%

Autoantibodies to tubulin are specifically associated with the young age onset of the nasopharyngeal carcinoma

Jalbout

Jrad

Bouaouina

et al. 2002

Intl Journal of Cancer

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“…It is, however, reported that some cancer and even AIDS patients are also characterized by the increase in production of anti-dsDNA autoantibodies [3][4][5][6][7]. Although our understanding of autoimmune diseases remains confused, origins of anti-dsDNA autoantibodies and their pathological role have been widely investigated.…”

Section: Introductionmentioning

confidence: 99%

Origin and anti-tumor effects of anti-dsDNA autoantibodies in cancer patients and tumor-bearing mice

Zhang

et al. 2005

Immunology Letters

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“…After this study, other publications showed how the presence of high RF titers in patient sera were associated with an increased cancer risk, tumor recurrence, and tumor load if compared with patients that were RF-negative [ 54 , 55 , 56 , 57 , 58 , 59 , 60 ].…”

Section: Rheumatoid Factor and Cancer Historymentioning

confidence: 90%

Rheumatoid Factor: A Novel Determiner in Cancer History

Ugolini

Nuti

2021

Cancers

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The possible interplay between autoimmunity and cancer is a topic that still needs to be deeply explored. Rheumatoid factors are autoantibodies that are able to bind the constant regions (Fc) of immunoglobulins class G (IgGs). In physiological conditions, their production is a transient event aimed at contributing to the elimination of pathogens as well as limiting a redundant immune response by facilitating the clearance of antibodies and immune complexes. Their production can become persistent in case of different chronic infections or diseases, being for instance a fundamental marker for the diagnosis and prognosis of rheumatoid arthritis. Their presence is also associated with aging. Some studies highlighted how elevated levels of rheumatoid factors (RFs) in the blood of patients are correlated with an increased cancer risk, tumor recurrence, and load and with a reduced response to anti-tumor immunotherapies. In line with their physiological roles, RFs showed in different works the ability to impair in vitro anti-cancer immune responses and effector functions, suggesting their potential immunosuppressive activity in the context of tumor immunity. Thus, the aim of this review is to investigate the emerging role of RFs as determiners of cancer faith.

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Autoantibodies in early breast cancer: a stage-related phenomenon?

Cited by 29 publications

References 9 publications

Autoantibodies to tubulin are specifically associated with the young age onset of the nasopharyngeal carcinoma

Autoantibodies to tubulin are specifically associated with the young age onset of the nasopharyngeal carcinoma

Origin and anti-tumor effects of anti-dsDNA autoantibodies in cancer patients and tumor-bearing mice

Rheumatoid Factor: A Novel Determiner in Cancer History

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