Autoantibodies in outbred Swiss Webster mice following exposure to gold and mercury

Amirhosseini, Mehdi; Alkaissi, Hammoudi; Hultman, Per; Havarinasab, Said

doi:10.1016/j.taap.2020.115379

Cited by 5 publications

(2 citation statements)

References 57 publications

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“…Clearly, because of biomagnification, pollutants are mostly concentrated in the longer-living and larger predatory fish species such as swordfish, tuna, and shark. Classical fish contaminants are the heavy metals, with Hg being worthy of mention in this review because it acts as an environmental trigger of autoimmunity ( 17 , 44 – 51 ), a mechanism that has also been observed for cadmium (Cd) ( 51 – 55 ). In predatory marine fish, approximately 90% of Hg is methylated (methylmercury), while the remainder consists of minimal amounts of inorganic mercury, ethylmercury, and phenylmercury ( 4 ).…”

Section: The Bad Face Of Janusmentioning

confidence: 99%

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Fish and the Thyroid: A Janus Bifrons Relationship Caused by Pollutants and the Omega-3 Polyunsaturated Fatty Acids

et al. 2022

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Benefits of the omega-3 polyunsaturated fatty acids (PUFA) on a number of clinical disorders, including autoimmune diseases, are widely reported in the literature. One major dietary source of PUFA are fish, particularly the small oily fish, like anchovy, sardine, mackerel and others. Unfortunately, fish (particularly the large, top-predator fish like swordfish) are also a source of pollutants, including the heavy metals. One relevant heavy metal is mercury, a known environmental trigger of autoimmunity that is measurable inside the thyroid. There are a number of interactions between the omega-3 PUFA and thyroid hormones, even at the level of the thyroid hormone transport proteins. Concerning the mechanisms behind the protection from/amelioration of autoimmune diseases, including thyroiditis, that are caused by the omega-3 PUFA, one can be the decreased production of chemokines, a decrease that was reported in the literature for other nutraceuticals. Recent studies point also to the involvement of resolvins. The intracellular increase in resolvins is associated with the tissue protection from inflammation that was observed in experimental animals after coadministration of omega-3 PUFA and thyroid hormone. After having presented data on fish consumption at the beginning, we conclude our review by presenting data on the market of the dietary supplements/nutraceuticals. The global omega-3 products market was valued at USD 2.10 billion in 2020, and was projected to go up at a compound annual growth rate of 7.8% from 2020 to 2028. Among supplements, fish oils, which are derived mainly from anchovies, are considered the best and generally safest source of omega-3. Taking into account (i) the anti-autoimmunity and anti-cancer properties of the omega-3 PUFA, (ii) the increasing incidence of both autoimmune thyroiditis and thyroid cancer worldwide, (iii) the predisposing role for thyroid cancer exerted by autoimmune thyroiditis, and (iv) the risk for developing metabolic and cardiovascular disorders conferred by both elevated/trendwise elevated serum TSH levels and thyroid autoimmunity, then there is enough rationale for the omega-3 PUFA as measures to contrast the appearance and/or duration of Hashimoto’s thyroiditis as well as to correct the slightly elevated serum TSH levels of subclinical hypothyroidism.

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Section: The Bad Face Of Janusmentioning

confidence: 99%

“…In the preceding section, we have reminded the role of Hg as an autoimmunity trigger ( 17 , 44 – 51 ). However, omega-3 PUFA antagonize this effect of Hg ( 128 , 129 ).…”

Section: Fish and Omega-3 Pufa As Protection From Thyroid Disordersmentioning

confidence: 99%

Fish and the Thyroid: A Janus Bifrons Relationship Caused by Pollutants and the Omega-3 Polyunsaturated Fatty Acids

et al. 2022

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Working with Miraculous Mice: Mus musculus as a Model Organism

Standley,

Xie,

Lau

et al. 2024

Current Protocols

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The laboratory mouse has been described as a “miracle” model organism, providing a window by which we may gain an understanding of ourselves. Since the first recorded mouse experiment in 1664, the mouse has become the most used animal model in biomedical research. Mice are ideally suited as a model organism because of their small size, short gestation period, large litter size, and genetic similarity to humans. This article provides a broad overview of the laboratory mouse as a model organism and is intended for undergraduates and those new to working with mice. We delve into the history of the laboratory mouse and outline important terminology to accurately describe research mice. The types of laboratory mice available to researchers are reviewed, including outbred stocks, inbred strains, immunocompromised mice, and genetically engineered mice. The critical role mice have played in advancing knowledge in the areas of oncology, immunology, and pharmacology is highlighted by examining the significant contribution of mice to Nobel Prize winning research. International mouse mutagenesis programs and accurate phenotyping of mouse models are outlined. We also explain important considerations for working with mice, including animal ethics; the welfare principles of replacement, refinement, and reduction; and the choice of mouse model in experimental design. Finally, we present practical advice for maintaining a mouse colony, which involves adequate training of staff, the logistics of mouse housing, monitoring colony health, and breeding strategies. Useful resources for working with mice are also listed. The aim of this overview is to equip the reader with a broad appreciation of the enormous potential and some of the complexities of working with the laboratory mouse in a quest to improve human health. © 2024 The Author(s). Current Protocols published by Wiley Periodicals LLC.

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Immunotoxicology of metals

Hultman¹,

Pollard²

2022

Handbook on the Toxicology of Metals

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Autoantibodies in outbred Swiss Webster mice following exposure to gold and mercury

Cited by 5 publications

References 57 publications

Fish and the Thyroid: A Janus Bifrons Relationship Caused by Pollutants and the Omega-3 Polyunsaturated Fatty Acids

Fish and the Thyroid: A Janus Bifrons Relationship Caused by Pollutants and the Omega-3 Polyunsaturated Fatty Acids

Working with Miraculous Mice: Mus musculus as a Model Organism

Immunotoxicology of metals

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