Autoantibodies to glutamic acid decarboxylase in diabetic patients from a multi‐ethnic Australian community: the Fremantle Diabetes Study

Davis, Timothy; Zimmet, Paul; Davis, Wendy A.; Bruce, David; Fida, Shahnaz; Mackay, Ian R.

doi:10.1046/j.1464-5491.2000.00359.x

Cited by 119 publications

(189 citation statements)

References 38 publications

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“…Baseline assessment (1993)(1994)(1995)(1996) At baseline a comprehensive history of diabetes and comorbid conditions was taken, a physical examination was performed and the patients provided fasting blood and urine samples for standard biochemical tests, including serum glucose, HbA 1c , serum lipoproteins and albumin : creatinine ratio (ACR) [20][21][22][23]. Complications were identified using standard definitions.…”

Section: Clinical and Laboratory Methodsmentioning

confidence: 99%

“…Of 2258 diabetic patients identified between 1993 and 1996, 1426 (63%) were recruited to the FDS and 1294 (91%) had type 2 diabetes. Identification and recruitment methods, sample characteristics, including classification of diabetes and details of non-recruited patients, have been described elsewhere [20,21]. 31 December 2002, were invited to participate in a study of cognitive function.…”

Section: Subjectsmentioning

confidence: 99%

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Vascular depression in older people with diabetes

et al. 2006

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Aims/hypothesis Cerebrovascular disease may be causal or a vulnerability factor in late-onset depression and may explain the high rate of depression in older adults with diabetes. We explored a wide range of potential explanatory variables of depression in a longitudinal study of older diabetic subjects to investigate the vascular depression hypothesis in these patients. Methods We recruited 207 subjects with diabetes selected for potential cognitive deficits from an existing observational cohort study (average age 75.7±4.6 years, 52.2% men) for an assessment of depression using a standardised diagnostic instrument (Cambridge Examination for Mental Disorders of the Elderly -Revised). All subjects underwent a detailed clinical assessment at baseline and at follow-up (after 7.5± 1.1 years). Results Major depression was present in 45 subjects (21.7%) and minor depression in ten (4.8%). A positive history of strokes and the presence of peripheral arterial disease were significantly associated with depression at the time of diagnosis. In a subsample of 93 cases who underwent structural neuroimaging, the presence of cerebral infarcts was also significantly associated with depression. Treatment with glucose-lowering therapy, higher serum cholesterol levels and difficulties with activities of daily living at baseline were significant predictors of depression at follow-up. Conclusions/interpretation A history of cerebrovascular disease was strongly associated with depression and cerebrovascular risk factors were significant predictors of depression in older diabetic patients. Our findings are consistent with the hypothesis that the excess risk of depression in older diabetic patients is related to underlying cerebrovascular disease.

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Section: Clinical and Laboratory Methodsmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Vascular depression in older people with diabetes

et al. 2006

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“…The Fremantle Diabetes Study (FDS) recruited 1,426 diabetic patients (63%) from 2,258 identified in a postcode-defined urban Australian community between 1993 and 1996. Details of the FDS, including patient characteristics and methods used to diagnose diabetes, have been described previously [14]. In February 2001, there were 587 FDS survivors aged ≥70 years, of whom 302 (51.4%) agreed to undergo cognitive assessment.…”

Section: Patientsmentioning

confidence: 99%

“…Detailed sociodemographic, clinical and biochemical data were available at FDS entry for the present 302 patients and these data were updated on recruitment to the present study [14]. In addition, the FDS database was linked to the Western Australia Data Linkage System (WADLS) [16].…”

Section: Baseline Assessmentmentioning

confidence: 99%

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Severe hypoglycaemia and cognitive impairment in older patients with diabetes: the Fremantle Diabetes Study

et al. 2009

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Aims/hypothesis The aim was to investigate the relationship between severe hypoglycaemia and cognitive impairment in older patients with diabetes. Methods A sample of 302 diabetic patients aged ≥70 years was assessed for dementia or cognitive impairment without dementia in 2001-2002 and a subsample of non-demented patients (n=205) was followed to assess cognitive decline. A history of severe hypoglycaemia was determined from self-reports, physician assessments and records of health service use for hypoglycaemia (HSH). Prospective HSH was determined up to 2006. Data analysis, including multiple logistic and Cox regression models, was used to determine whether: (1) there were cross-sectional associations between hypoglycaemia and cognitive status, (2) historical hypoglycaemia predicted cognitive decline, and (3) baseline cognitive status predicted subsequent HSH.Results There were significant cross-sectional associations between both cognitive impairment and dementia and hypoglycaemia. Independent risk factors for future HSH included dementia (hazard ratio 3.00, 95% CI 1.06-8.48) and inability to self-manage medications (hazard ratio 4.17, 95% CI 1.43-12.13). However, there were no significant associations between historical hypoglycaemia, incident HSH and cognitive decline. Conclusions/interpretation Dementia is an important risk factor for hypoglycaemia requiring health service utilisation. We found no evidence that hypoglycaemia contributes to cognitive impairment in older patients with diabetes.

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Current Awareness

2001

Diabetes Metab. Res. Rev.

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 17 sections: 1 Books, Reviews & Symposia; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Prediction; 7 Prevention; 8 Intervention: a) General; b) Pharmacology; 9 Pathology: a) General; b) Cardiovascular; c) Neurological; d) Renal; 10 Endocrinology & Metabolism; 11 Nutrition; 12 Animal Studies; 13 Techniques. Within each section, articles are listed in alphabetical order with respect to author (11 Weeks journals ‐ Search completed at 15th Nov. 2000)

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Autoantibodies to glutamic acid decarboxylase in diabetic patients from a multi‐ethnic Australian community: the Fremantle Diabetes Study

Cited by 119 publications

References 38 publications

Vascular depression in older people with diabetes

Vascular depression in older people with diabetes

Severe hypoglycaemia and cognitive impairment in older patients with diabetes: the Fremantle Diabetes Study

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