2014
DOI: 10.1016/j.jneuroim.2014.09.001
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Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy

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Cited by 33 publications
(22 citation statements)
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“…One study found that 62% of patients had IgG autoantibodies against gliomedin or NF186 in combination with anti-GM1 IgM or alone in 10% of patients 78. In the same study, antibodies to gliomedin or NF186 were found in only 1% of patients with CIDP.…”
Section: Chronic Autoimmune Paranodopathies: Expanding the Conceptmentioning
confidence: 90%
“…One study found that 62% of patients had IgG autoantibodies against gliomedin or NF186 in combination with anti-GM1 IgM or alone in 10% of patients 78. In the same study, antibodies to gliomedin or NF186 were found in only 1% of patients with CIDP.…”
Section: Chronic Autoimmune Paranodopathies: Expanding the Conceptmentioning
confidence: 90%
“…Like many other myelin proteins, gliomedin is a target for autoantibodies in peripheral neuropathies (62)(63)(64), with implications for multifocal motor neuropathy, chronic inflammatory demyelinating polyneuropathy, and Guillain-Barré syndrome. The exact autoimmune epitopes on gliomedin are not yet known.…”
Section: Discussionmentioning
confidence: 99%
“…Application of high concentration anti-GM1 sera to rat single myelinated axons after addition of complement, reduced Na + currents sufficient to block action potential electrogenesis 41. Very recently, complement activating antibodies to neurofascin and or gliomedin were found in 62% of patients with MMN; interestingly 10% of patients without IgM anti-GM1 reactivity had antineurofascin antibodies 42. The localisation and function of neurofascin and gliomedin (figure 1C) suggest an additional role of antibodies to these axoglial proteins in the involvement of the nodal region in MMN.…”
Section: Nodopathies Of the Peripheral Nervementioning
confidence: 99%