Autoantibodies to protein transport and messenger RNA processing pathways: endosomes, lysosomes, Golgi complex, proteasomes, assemblyosomes, exosomes, and GW bodies

Stinton, Laura M.; Eystathioy, Theophany; Selak, Sanja; Chan, Edward K. L.; Fritzler, Marvin J.

doi:10.1016/j.clim.2003.10.005

Cited by 82 publications

(62 citation statements)

References 165 publications

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“…The ICAP group learned that in addition to laboratories that report anti-CytAb as a negative ANA, others generate separate reports indicating the presence of "true" ANA and/or antibodies to "other" (i.e., mitotic spindle, cytoplasmic, cell surface) reactivity, and some report a positive ANA when cytoplasmic components are reactive, such as mitochondria, cytoskeleton, GW/P bodies, endosomes, Golgi complex, endoplasmic reticulum, or the cytosol 6 . In considering this lack of standardized ANA reporting, the ICAP committee considered alternative nomenclature, such as anticellular antibodies, but after recognizing that the ANA terminology is entrenched in the literature, agreed to continue to use the term ANA, intending it to refer to the spectrum of intracellular components 5 .…”

Section: To the Editormentioning

confidence: 99%

The Antinuclear Antibody Test in the Diagnosis of Antisynthetase Syndrome and Other Autoimmune Myopathies

2018

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Section: To the Editormentioning

confidence: 99%

The Antinuclear Antibody Test in the Diagnosis of Antisynthetase Syndrome and Other Autoimmune Myopathies

2018

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“…Elevated levels of SS-A/Ro and SS-B/La mRNA were found in the salivary tissues of SS patients with xerostomia (Bolstad et al, 2003). Lupus-associated autoantigens also include golgins present in the Golgi apparatus and coilin proteins (Stinton et al, 2004).…”

mentioning

confidence: 99%

Inhibition of Autoantigen Expression by (-)-Epigallocatechin-3-gallate (the Major Constituent of Green Tea) in Normal Human Cells

Hsu

Dickinson

Qin

et al. 2005

J Pharmacol Exp Ther

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“…It is intriguing whether Rab1 GTPase which is located in the Golgi apparatus, including the family of golgin proteins (35) similarly located, are directly accessible to the anti-GTP and anti-golgin Abs synthesized in this organelle that are found in some autoimmune disorders (9,36).…”

Section: Discussionmentioning

confidence: 99%

Cells That Produce Deleterious Autoreactive Antibodies Are Vulnerable to Suicide

Niu

Leung

Hung

et al. 2008

The Journal of Immunology

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It is puzzling how autoreactive B cells that escape self-tolerance mechanisms manage to produce Abs that target vital cellular processes without succumbing themselves to the potentially deleterious effects of these proteins. We report that censorship indeed exists at this level: when the Ab synthesis in the cell is up-regulated in IL-6-enriched environments (e.g., adjuvant-primed mouse peritoneum), the cell dies of the increased intracellular binding between the Ab and the cellular autoantigen. In the case in which telomerase is the autoantigen, mouse hybridoma cells synthesizing such an autoantibody, which appeared to grow well in culture, could not grow in syngeneic BALB/c mice to form ascites, but grew nevertheless in athymic siblings. Culture experiments demonstrated that peritoneal cell-derived IL-6 (and accessory factors) affected the growth and functions of the hybridoma cells, including the induction of mitochondria-based apoptosis. Electron microscopy revealed an abundance of Abs in the nuclear chromatin of IL-6-stimulated cells, presumably piggy-backed there by telomerase from the cytosol. This nuclear presence was confirmed by light microscopy analysis of isolated nuclei. In two other cases, hybridoma cells synthesizing an autoantibody to GTP or osteopontin also showed similar growth inhibition in vivo. In all cases, Ab function was crucial to the demise of the cells. Thus, autoreactive cells, which synthesize autoantibodies to certain intracellular Ags, live delicately between life and death depending on the cytokine microenvironment. Paradoxically, IL-6, which is normally growth-potentiating for B cells, is proapoptotic for these cells. The findings reveal potential strategies and targets for immunotherapy.

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Autoantibodies to protein transport and messenger RNA processing pathways: endosomes, lysosomes, Golgi complex, proteasomes, assemblyosomes, exosomes, and GW bodies

Cited by 82 publications

References 165 publications

The Antinuclear Antibody Test in the Diagnosis of Antisynthetase Syndrome and Other Autoimmune Myopathies

The Antinuclear Antibody Test in the Diagnosis of Antisynthetase Syndrome and Other Autoimmune Myopathies

Inhibition of Autoantigen Expression by (-)-Epigallocatechin-3-gallate (the Major Constituent of Green Tea) in Normal Human Cells

Cells That Produce Deleterious Autoreactive Antibodies Are Vulnerable to Suicide

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