Autoantibodies to Spermatozoa in Relation to Male Infertility and Vasectomy

Halim, A.

doi:10.1111/j.1464-410x.1973.tb06822.x

Cited by 39 publications

(14 citation statements)

References 9 publications

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“…Human ejaculated spermatozoa that show head-to-head agglutination exhibit low fertility (Halim & Antoniov, 1973) but this has not been shown for all the species studied (Bedford, 1970). An antagglutinin has been isolated from the ejaculates of several species (Lindahl et al, 1954), including man (Bullimore et al, 1981) but the occurrence of head-to-head agglutination of ejaculated spermatozoa may not be related to an epididymal antagglutinin deficiency because such a factor has also been found in prostatic secretions of the bull (Lindahl et al, 1954).…”

Section: Discussionmentioning

confidence: 96%

Head-to-head agglutination of ram and boar epididymal spermatozoa and evidence for an epididymal antagglutinin

Dacheux¹,

Paquignon²,

Combarnous³

1983

Reproduction

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Spermatozoa from the corpus epididymidis of boars and rams showed head\x=req-\ to-head agglutination when diluted. The occurrence of agglutination coincided with the appearance of motility but preceded the ability to bind to zona-free hamster eggs. Head-to-head agglutination was inhibited by the addition of caudal epididymal plasma. A protein acting as an antagglutinin on spermatozoa from the corpus epididymidis was extracted from cauda epididymal plasma and partly purified.

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Section: Discussionmentioning

confidence: 96%

Head-to-head agglutination of ram and boar epididymal spermatozoa and evidence for an epididymal antagglutinin

Dacheux¹,

Paquignon²,

Combarnous³

1983

Reproduction

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“…Since then anti-sperm antibodies have been studied extensively in serum and seminal plasma and their role in male subfertility has been recognized (Rumke, 1954;Wilson, 1954). Halim and Antoniou (1973) demonstrated the presence of antisperm antibodies in the serum or seminal plasma of 8-13% of infertile men. However, men with demonstrable antisperm antibodies often father children and this has given rise to the suggestion that any decreased fertility due to the presence of these antibodies may depend on the antibody titre (Rumke et al, 1974).…”

Section: Introductionmentioning

confidence: 97%

Total number of immunocompetent cells in the normal rat epididymis and after vasectomy

Hooper

Smythe²,

Richards³

et al. 1995

Reproduction

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The aim of this study was to make unbiased quantitative estimates of the number of T8 cytotoxic cells and T4 helper cells and macrophages in the head and tail of rat epididymides, using newly developed design-based stereological methods in fertile control animals, and to compare these with results from vasectomized animals. The location of these cells within the intra- and interepithelial compartments of the epididymis was also studied. In control animals, both the T4 helper cells and macrophages and T8 cytotoxic cells were found in significantly higher numbers (P < 0.01) in the head interepithelial location than in the intraepithelial site. In addition, there were significantly more (P < 0.01) T8 cytotoxic cells in the tail interepithelial region. Within the head region of vasectomized rats, there was a significant increase in T8 cytotoxic cells in the intraepithelial location (P < 0.01), and a decrease in T4 helper cells and macrophages in the interepithelial region (P < 0.05). Serum samples from vasectomized animals, when compared with those from control animals, showed a significant increase in cytotoxic antisperm antibody. This suggests that, in response to the increased spermatozoal antigenic absorption that takes place in the epididymis after vasectomy, the immune system redistributes its T cell subsets to modify the immune tolerance that may occur.

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“…Antisperm antibodies can be detected both in sera and in seminal plasma of about 10% of naturally infertile men [7,81. They may either inhibit sperm motility acting on spermatozoa as immobilizing or agglutinating factors [5,9,111 or interfere with normal sperm penetration of cervical mucus [2,10,121; finally, they might prevent egg penetration by blocking specific receptors on the sperm surface, as evidenced by the hamster egg test [2, 161. Men with high titers of antisperm antibodies are less able to cause pregnancy than those with low titer or free from antibodies [6], although the immunity to sperm is not an all-or-none phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Immunomagnetic Method to Select Human Sperm Without Sperm Surface-Bound Autoantibodies in Male Autoimmune Infertility

Varotto

Caretto

1990

Archives of Andrology

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Using supermagnetic polymer microspheres coated with anti-immunoglobulins, spermatozoa without autoantibodies bound on their surface can be isolated from a sperm population showing a variable percentage of cells with autoantibodies bound on their surface. This simple technique seems to induce no modification of semen qualities; therefore, the concentration of sperm after immunomagnetic separation might be useful for in vivo or in vitro insemination in infertile couples with.autoimmune male infertility.

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Autoantibodies to Spermatozoa in Relation to Male Infertility and Vasectomy

Cited by 39 publications

References 9 publications

Head-to-head agglutination of ram and boar epididymal spermatozoa and evidence for an epididymal antagglutinin

Head-to-head agglutination of ram and boar epididymal spermatozoa and evidence for an epididymal antagglutinin

Total number of immunocompetent cells in the normal rat epididymis and after vasectomy

Immunomagnetic Method to Select Human Sperm Without Sperm Surface-Bound Autoantibodies in Male Autoimmune Infertility

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