Autoantibodies to thyroid peroxidase in patients with type 1 diabetes in Taiwan

Chang, Chiz‐Tzung; Huang, Chien‐Ning; Chuang, Lee‐Ming

doi:10.1530/eje.0.1390044

Cited by 42 publications

(27 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, an increased anti-GAD positivity was observed in patients whose duration of diabetes was less than one year compared with that of those whose duration of diabetes was longer than one year; but the difference between two groups was statistically insignificant. Consistent with our results, Chang and his colleagues determined no relations between anti-GAD positivity and duration of diabetes and gender [10].…”

Section: Discussionsupporting

confidence: 92%

“…In the study by Chang et al on type 1 diabetics in Taiwan, it was demonstrated that the presence of positive anti-TPO in the presence of anti-GAD was 23.2%. This difference was not statistically significant when compared with the 22% positivity among cases negative for anti-GAD [10]. Premawardhana et al did not find any statistical difference between anti-GAD65/anti-IA-2 positive and negative type 1 DM patients in terms of TA [22].…”

Section: Discussionmentioning

confidence: 84%

“…Ultrasound studies of the thyroid gland have shown that typical patterns of parenchyma hypoechogenicity, as well as gland enlargement, may be present in patients with ATD [9]. In adults with longstanding type 1 DM, 27% to 44% of patients have thyroid autoantibodies (TA) [10,11], while 23% to 25% of these patients develop abnormal TSH values (sub-or clinical hypo-or hyperthyroidism) [6,7].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Autoimmune thyroid disease in patients with anti-GAD positive type 1 diabetes mellitus

et al. 2009

View full text Add to dashboard Cite

AbstractThe aim of the study was to determine the frequency and titers of anti-thyroid peroxidase (Anti-TPO), anti-thyroglobulin (Anti-TG), and anti-glutamic acid decarboxylase (Anti-GAD) antibodies in Turkish patients with type 1 diabetes mellitus (DM), and to compare the frequency of anti-TPO and anti-TG titers in the presence or absence of anti-GAD. A total of 104 patients including 56 males and 48 females with type 1 DM and their age-, gender-, and body mass index-matched control group, including 31 males and 27 females, 58 cases in total with an age range of 15-50 years, were recruited into this study. In patients with type 1 DM, positive anti-GAD was detected in 30.8% (n=32). In patients with positive anti-GAD, rate of positive anti-TPO was 37.5%; however, in patients with negative anti-GAD, the rate of positive anti-TPO was 9.7% and the difference was statistically significant (p=0.001). In patients with positive anti-GAD, the rate of positive anti-TG was 18.8%. In patients with negative anti-GAD, the rate of positive anti-TG was 2.8%, and the difference between them was statistically significant (p=0.005). In patients with positive and negative anti-GAD, rates of both positive anti-TPO and anti-TG were 15.6% and 1.4%, respectively, with the difference showing statistical significance (p=0.004). Thyroid autoimmunity in type 1 DM patients with positive anti-GAD was apparently higher; therefore, these patients should be followed more frequently and carefully.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Autoimmune thyroid disease in patients with anti-GAD positive type 1 diabetes mellitus

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Similarly, in a study of patients with long-standing DM 1 (mean follow-up 18 years) by Umpierrez GE et al, the prevalence of anti-TPO was 33%. In other studies concerning patients with shorter disease duration the anti-TPO prevalence is much lower (19.3% and 21.8% respectively) [19,20]. In a study conducted in Polish population, Madej A. reports the anti-TPO prevalence in 26.9% of patients with mean DM 1 duration of 12.7 years [21].…”

Section: Fig 1 Prevalence Of Anti-tpo According To Tsh After Excludmentioning

confidence: 93%

Prevalence of Anti-Thyroid Peroxidase in Adults with Type 1 Diabetes Participating in Poznań Prospective Study

et al. 2015

View full text Add to dashboard Cite

Background. Type 1 diabetes (DM 1) is frequently associated with autoimmune thyroid diseases (AITD). Screening for AITD in adults is rarely performed. The aim of this study was to evaluate the prevalence of anti-thyroid peroxidase (anti-TPO) and thyroid function and their association with metabolic control in adults participating in Poznan Prospective Study (PoProStu). Material and Methods. The analysis included 74 patients (26 women and 48 men) aged 38.5 (IQR: 34.5-42.5), who have had diabetes for 15.0 (14-16) years. All patients have been treated with intensive functional insulin therapy (IFIT) from the onset of the disease. Anti-TPO and thyroid-stimulating hormone (TSH) were determined. The concentration of anti-TPO ≥ 5.61 IU/mL was considered positive. Based on the levels of anti-TPO the patients were divided into two groups: anti-TPO positive and anti-TPO negative. Metabolic control was assessed by the level of glycated hemoglobin (HbA 1c ). Results. Anti-TPO was positive in 32 (43.2%) patients. Prevalence of autoantibodies was significantly higher in women (53% vs 21%; p = 0.009). There was no significant difference in HbA 1c levels [median (IQR): 7.6% (7.1-8.6) vs 7.6% (7.1-8.8); p = 0.82] and TSH levels [median (IQR): 2.05 µIU/mL (1.23-3.15) vs 1.62 µIU/mL (1.00-2.10); p = 0.06] between anti-TPO positive and negative patients. After excluding patients with a thyroid dysfunction, a significant difference in TSH levels between anti-TPO positive and negative group was found [median (IQR): 2.11 µIU/mL (1.29-3.31) vs 1.66 µIU/mL (1.29-3.31); p = 0.04]. Conclusions. High anti-TPO prevalence is found in adult patients with long-standing DM 1, and autoantibodies occur more often in women. Therefore, screening for asymptomatic thyroid dysfunction should be performed in this group, as already recommended by the joint statement of Polish Society of Endocrinology and Diabetes Poland (Adv Clin Exp Med 2015, 24, 1, 79-84).

show abstract

“…Each disease is thought to be influenced by multiple susceptibility genes, as well as, environmental factors (10). The high prevalence of anti-thyroid peroxidase antibodies (anti-TPO) in patients with T1D prompts the necessity for further thyroid function evaluation (11). Patients with thyroid autoimmunity may also have higher antibody titers to beta cells (12).…”

Section: Introductionmentioning

confidence: 99%

Organ Specific Autoantibodies in Preclinical and Early Clinical Type 1 Diabetes in Turkey

Erten¹,

Gürol²,

Deniz³

et al. 2007

Upsala Journal of Medical Sciences

View full text Add to dashboard Cite

Type 1 diabetes mellitus (T1D) patients (G1; n=73) and first degree relatives with of FPIR (G2; n=18) were screened for two other autoantibodies, anti-glutamic acid decarboxylase (GADA) and insulin autoantibodies (IAA), and for other organ-specific autoantibodies, anti-gastric parietal cell (anti-PCA) and anti-thyroid peroxidase (anti-TPO) as well. The two control groups consisted of healthy subjects (G3; n:55 and G4; n:13). In G1, positivity of ICA, GADA, IAA, anti-TPO and anti-PCA were 63%, 75.1%, 27.4%, 17.8% and 8.2%, respectively. In G2, positivity for GADA, IAA, anti-TPO and anti-PCA were 55.6%, 11.1%, 16.7% and 11.1%, respectively. None of the anti-TPO or anti-PCA positive cases had clinical or laboratory thyroid disease or pernicious anemia.Other organ specific antibodies, in case they accompany GADA and/or IAA in high risk individuals, result in higher risk for T1D. Moreover, this condition may indicate future potential for developing thyrogastric autoimmune diseases.In conclusion; autoantibodies are markers for autoimmune destruction in T1D, and for identification of subjects at risk for disease. Even at the time of diagnosis of T1D, screening for thyrogastric autoimmunity might be recommended for early detection of the relevant diseases.

show abstract

Autoantibodies to thyroid peroxidase in patients with type 1 diabetes in Taiwan

Cited by 42 publications

References 34 publications

Autoimmune thyroid disease in patients with anti-GAD positive type 1 diabetes mellitus

Autoimmune thyroid disease in patients with anti-GAD positive type 1 diabetes mellitus

Prevalence of Anti-Thyroid Peroxidase in Adults with Type 1 Diabetes Participating in Poznań Prospective Study

Organ Specific Autoantibodies in Preclinical and Early Clinical Type 1 Diabetes in Turkey

Contact Info

Product

Resources

About