Autoantibody against dendrite in Plasmodium falciparum infection: A singular auto-immune phenomenon preferentially in cerebral malaria

Gallien, Sébastien; Roussilhon, Christian; Blanc, Catherine; Pérignon, Jean‐Louis; Druilhe, Pierre

doi:10.1016/j.actatropica.2011.01.005

Cited by 9 publications

(3 citation statements)

References 20 publications

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“…While it is true no previous studies carried out in Brazilian Amazon populations exposed to Hg found a correlation between autoantibodies and malaria status, it is equally true that patients with malaria have autoantibodies (Pradhan et al, 2002;Gallien et al, 2011). In a study of 173 acute hospitalized patients who were suffering from malaria, positive ANA and anti-neutrophil cytoplasmic antibodies (ANCA) test results were found in more than 20% of cases infected with Plasmodium falciparum and 15% of cases infected with Plasmodium vivax.…”

Section: Discussionmentioning

confidence: 99%

Lack of autoantibody induction by mercury exposure in artisanal gold mining settings in Colombia: Findings and a review of the epidemiology literature

Rodríguez¹,

Flórez-Vargas²,

Rodríguez-Villamizar³

et al. 2014

Journal of Immunotoxicology

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Mercury (Hg) has been implicated as an immunotoxicant in experimental animal models, but its role in the induction of human autoimmunity remains unclear due to contradictory findings. Therefore, it has been claimed that it is important to examine other populations in order to clarify the role of Hg in these diseases. The aim of this study was to investigate whether occupational Hg exposure due to artisanal gold mining is associated with the prevalence of autoimmune biomarkers. A cross-sectional study was conducted comparing Hg-exposed gold miners (n = 164) with a control population (n = 127). Hair, blood, and 24-h urine samples were collected for measures of Hg levels, as well as of anti-nuclear antibodies (ANA) and rheumatoid factor (RF). Participants were clinically evaluated by a general practice physician, a rheumatologist, and a toxicologist. Statistically significant differences (p < 0.001) were found between Hg-exposed and non-exposed groups for all Hg biomarkers tested: blood (7.03 versus 2.46 µg Hg/L), urine (3.96 versus 1.48 µg Hg/g creatinine), and hair (0.79 versus 0.39 µg Hg/g). No difference was observed in ANA (cut-off titre of 1:80; PR = 0.93, 95% CI = 0.45-1.90) and RF (cut-off = 30 IU/mL; PR = 0.062, 95% CI = 0.03-1.08) status between the groups. In conclusion, the findings here do not support the hypothesis that Hg exposure due to artisanal gold mining activities had a significant impact on autoantibodies as biomarkers of autoimmune diseases. In a review context, the epidemiological findings were interpreted in light of the conflicting data in the literature about how Hg exposure was linked to development of autoantibodies. Validation of these findings in prospective studies is needed to firmly establish the role of Hg in development of autoimmunity in human populations.

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Section: Discussionmentioning

confidence: 99%

Lack of autoantibody induction by mercury exposure in artisanal gold mining settings in Colombia: Findings and a review of the epidemiology literature

Rodríguez¹,

Flórez-Vargas²,

Rodríguez-Villamizar³

et al. 2014

Journal of Immunotoxicology

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“…In addition to the self-reactive proteins mentioned above, the dendritic tree of Purkinje cell is another host component that has been considered a target of autoimmune responses in CM. In a cohort of Thai individuals, it has been demonstrated that levels of autoantibodies against dendrites are higher in P. falciparuminfected patients with CM than in those with uncomplicated malaria (Gallien et al, 2011). The pathogenic role of such autoantibodies was attributed to their ability in inhibiting in vitro development of Purkinje cells (Calvet et al, 1993).…”

Section: Cerebral Malariamentioning

confidence: 99%

“…14-3-3 ε brain protein Degranulation of mast cells, basophils, eosinophils and/or monocytes/macrophages Protection against severe Plasmodium falciparum malaria Duarte et al, 2012 Beta tubulin III (TBB3) Cytoplasm microtubule disruption Cerebral malaria associated to P. falciparum Füchtbauer et al, 1985;Bansal et al, 2009 Dendritic tree of Purkinje cell In vitro inhibition of Purkinje cells development Cerebral malaria associated to P. falciparum Calvet et al, 1993;Gallien et al, 2011 Erythrocyte band 3 protein Rigidity increase and in vitro clearance of non-parasitized RBCs Anemia associated to Plasmodium vivax Mourão et al, 2016Mourão et al, , 2018 In vitro P. falciparum cythoadherence blockage and in vivo adherence of RBCs; parasite growth inhibition Protection against P. falciparum malaria Hogh et al, 1994 ;Brahimi et al, 2011 Lipids Kidney injury through immune complex deposition…”

Section: Clinical Outcome Referencesmentioning

confidence: 99%

Autoantibodies and Malaria: Where We Stand? Insights Into Pathogenesis and Protection

Mourão

Cardoso-Oliveira

Braga

2020

Front. Cell. Infect. Microbiol.

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Autoantibodies are frequently reported in patients with malaria, but whether they contribute to protection or to pathology is an issue of debate. A large body of evidence indicates that antibodies against host-self components are associated to malaria clinical outcomes such as cerebral malaria, renal dysfunction and anemia. Nonetheless, self-reactive immunoglobulins induced during an infection can also mediate protection. In light of these controversies, we summarize here the latest findings in our understanding of autoimmune responses in malaria, focusing on Plasmodium falciparum and Plasmodium vivax. We review the main targets of self-antibody responses in malaria as well as the current, but still limited, knowledge of their role in disease pathogenesis or protection.

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Malaria and Autoimmunity

Ohayon,

Lavine,

Mahroum

2024

Infection and Autoimmunity

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Autoantibody against dendrite in Plasmodium falciparum infection: A singular auto-immune phenomenon preferentially in cerebral malaria

Cited by 9 publications

References 20 publications

Lack of autoantibody induction by mercury exposure in artisanal gold mining settings in Colombia: Findings and a review of the epidemiology literature

Lack of autoantibody induction by mercury exposure in artisanal gold mining settings in Colombia: Findings and a review of the epidemiology literature

Autoantibodies and Malaria: Where We Stand? Insights Into Pathogenesis and Protection

Malaria and Autoimmunity

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