Autoantibody profiling of benign and malignant thyroid tumors and design of a prototype diagnostic array

Lanshchakov, K V; Belousov, Pavel V.; Ванушко, В Э; Abrosimov, Alexander; Kuprash, Dmitry V.; Кузнецов, Н С

doi:10.14341/2306-3513-2012-2-15-20

Cited by 3 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a somewhat similar study, we used a mini-array of 21 recombinant TAAs identified in non-thyroid human cancers to test their serological reactivity in 26 DTC and 22 FTA patients [ 141 ]. We were able to ultimately identify a three-features TAA signature (ankyrin repeat domain containing-protein 30A ANKRD30A, also known as NY-BR-1; regulator of G protein signaling 5 RGS5; and a particular isoform of hydrocephalus-inducing 2 HYDIN2 - KIAA1864) capable of significantly discriminating DTC from FTA cases both using individual TAAs (DSn of 19% for each; DSP of 95–100%) ( Figure 2 ) and combined three-features TAA panel (DSn of 50%; DSp of 95%).…”

Section: The Tumor-associated Antigens (Taas) and Their Cognate Autoa...mentioning

confidence: 99%

The Autoantibodies against Tumor-Associated Antigens as Potential Blood-Based Biomarkers in Thyroid Neoplasia: Rationales, Opportunities and Challenges

Belousov

2022

Biomedicines

View full text Add to dashboard Cite

The Autoantibodies targeting Tumor-Associated Antigens (TAA-AAbs) emerge as a result of a variety of tumor-related immunogenic stimuli and may be regarded as the eyewitnesses to the anti-tumor immune response. TAA-AAbs may be readily detected in peripheral blood to unveil the presence of a particular TAA-expressing tumor, and a fair number of TAAs eliciting the tumor-associated autoantibody response have been identified. The potential of TAA-AAbs as tumor biomarkers has been extensively studied in many human malignancies with a major influence on public health; however, tumors of the endocrine system, and, in particular, the well-differentiated follicular cell-derived thyroid neoplasms, remain understudied in this context. This review provides a detailed perspective on and legitimate rationales for the potential use of TAA-AAbs in thyroid neoplasia, with particular reference to the already established diagnostic implications of the TAA-AAbs in human cancer, to the windows for improvement and diagnostic niches in the current workup strategies in nodular thyroid disease and differentiated thyroid cancer that TAA-AAbs may successfully occupy, as well as to the proof-of-concept studies demonstrating the usefulness of TAA-AAbs in thyroid oncology, particularly for the pre-surgical discrimination between tumors of different malignant potential in the context of the indeterminate results of the fine-needle aspiration cytology.

show abstract

Section: The Tumor-associated Antigens (Taas) and Their Cognate Autoa...mentioning

confidence: 99%

The Autoantibodies against Tumor-Associated Antigens as Potential Blood-Based Biomarkers in Thyroid Neoplasia: Rationales, Opportunities and Challenges

Belousov

2022

Biomedicines

View full text Add to dashboard Cite

show abstract

Potential protein markers for differential diagnosis of thyroid neoplasms

Aksenova,

Bondarenko,

Ioutsi

et al. 2024

Clin Exp Thyroid

View full text Add to dashboard Cite

Tumors of the thyroid gland are extremely common. The incidence of malignant thyroid neoplasms has increased rapidly in recent decades, although it is unclear whether this is a true increase or the result of widespread use of screening ultrasound. The standard diagnostic procedure for determining the risk of malignancy and indications for surgical treatment of thyroid neoplasms is fine-needle aspiration biopsy followed by cytologic examination of the cellular aspirate. Despite the fact that in the majority of cases it is possible to make a differential diagnosis between thyroid cancer and benign thyroid masses, there is a diagnostic problem with intermediate categories of cytologic findings according to Bethesda, which makes it necessary to search for alternative solutions. This determines the need to expand preoperative diagnostic possibilities. One of the key directions of work on its realization is the study of proteomic data in various thyroid pathologies. The study of the proteome of thyroid tumors opens the possibility of identifying specific protein markers or mechanisms that play a key role in the oncogenesis and metastasis of thyroid tumors, as well as potential targets for new methods of diagnosis and treatment of these diseases. All this determines the relevance and practical importance of studying thyroid pathology at the molecular level, taking into account the potential of proteins as markers.

show abstract

Detection of Autoantibodies Recognizing Cancerretina Antigen Recoverin in Blood of Patients With Non-Invasive Follicular Thyroid Neoplasms With Papillary-Like Nuclear Features (Niftp)

et al. 2019

View full text Add to dashboard Cite

Autoantibodies recognizing the cancer-retina autoantigen called recoverin (RCVRN-AutoAb) may serve as a highly specific biomarker of cancer-associated retinopathy. However, they may also be found in some cancer patients without clinical evidence of retinopathy. In the present study, dot-ELISA and Western blot assays were used to demonstrate the presence of circulating RCVRN-AutoAb in 4/7 (57%) of patients with recently recognized pathological entity, non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); other thyroid tumors represented by follicular adenomas, and classical and follicular variants of papillary thyroid carcinomas, demonstrated low frequencies of RCVRN-AutoAb (0/15, 1/20 (5%) and 1/15 (7%), respectively), with no significant differences from healthy individuals (0/15). Our data implicate the circulating RCVRN-AutoAb as a potential biomarker of NIFTP capable of discrimination of this novel pathological entity from other thyroid tumors.

show abstract

Autoantibody profiling of benign and malignant thyroid tumors and design of a prototype diagnostic array

Cited by 3 publications

References 19 publications

The Autoantibodies against Tumor-Associated Antigens as Potential Blood-Based Biomarkers in Thyroid Neoplasia: Rationales, Opportunities and Challenges

The Autoantibodies against Tumor-Associated Antigens as Potential Blood-Based Biomarkers in Thyroid Neoplasia: Rationales, Opportunities and Challenges

Potential protein markers for differential diagnosis of thyroid neoplasms

Detection of Autoantibodies Recognizing Cancerretina Antigen Recoverin in Blood of Patients With Non-Invasive Follicular Thyroid Neoplasms With Papillary-Like Nuclear Features (Niftp)

Contact Info

Product

Resources

About