Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD

Yan, Yaping; Li, Yujing; Fu, Ying; Yang, Li; Su, Lei; Shi, Kaibin; Li, Minshu; Liu, Qiang; Borazanci, Aimee; Liu, Yaou; He, Yong; Bennett, Jeffrey L.; Vollmer, Timothy; Shi, Fu Dong

doi:10.1007/s11427-015-4997-y

Cited by 53 publications

(49 citation statements)

References 35 publications

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“…As some patients with NMO are MOG‐IgG‐positive, it is interesting to know if there are cases doubly positive for MOG‐IgG and AQP4‐IgG. In most recent studies with MOG‐IgG‐CBA, no patients possessed both MOG‐IgG and AQP4‐IgG, but some doubly positive cases have been reported …”

Section: Cba To Detect Mog‐iggmentioning

confidence: 99%

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Myelin oligodendrocyte glycoprotein immunoglobulin G‐associated disease: An overview

Fujihara

Sato

Nakashima

et al. 2018

Clinical & Exp Neuroim

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Myelin oligodendrocyte glycoprotein (MOG) is localized at the outermost layer of the myelin sheath and is accessible for autoantibodies. Although experimental autoimmune encephalitis induced with MOG immunization has been studied for 30 years, the results of previous reports on MOG immunoglobulin G (IgG) detection with enzyme-linked immunosorbent assay and Western blot are confusing. However, after the development of human MOG-transfected cell-based assay to detect conformational-sensitive MOG-IgG, unique groups of patients have been found seropositive, and MOG-IgG-associated disease has become a hot topic in clinical neuroimmunology. Currently, the clinical spectrum of MOG-IgG-associated disease includes idiopathic optic neuritis, acute disseminated encephalomyelitis, encephalitides (brainstem and cerebral cortical), idiopathic myelitis, atypical multiple sclerosis, aquaporin-4 IgG-negative neuromyelitis optica spectrum disorders and others. MOG-IgG-associated disease occurs in both children and adults, and the female:male ratio is almost 1:1. Pleocytosis in the cerebrospinal fluids during acute exacerbation is often seen, but oligoclonal IgG bands are usually negative. T helper cell 17, B cells and neutrophil-related cytokines appear to be upregulated intrathecally. The pathology of acute lesions is characterized by active inflammation demyelination with deposition of immunoglobulins and complements. Just like aquaporin 4 IgG-positive neuromyelitis optica spectrum disorders, some disease-modifying drugs for multiple sclerosis seem to be inefficacious in MOG-IgG-associated disease, and chronic immunosuppression is required to prevent relapse, especially in patients persistently positive for MOG-IgG. Our understanding of this newly recognized disease remains insufficient, and the progress of research is much expected.

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Section: Cba To Detect Mog‐iggmentioning

confidence: 99%

“…In most recent studies with MOG-IgG-CBA, no patients possessed both MOG-IgG and AQP4-IgG, but some doubly positive cases have been reported. 22,23 Clinical, magnetic resonance imaging and laboratory features…”

Section: Cba To Detect Mog-iggmentioning

confidence: 99%

Myelin oligodendrocyte glycoprotein immunoglobulin G‐associated disease: An overview

Fujihara

Sato

Nakashima

et al. 2018

Clinical & Exp Neuroim

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“…Çin'de yapılan bir çalışmada, 125 NMOSD tanılı hastanın 10'unda çifte pozitiflik saptanmış. Bu hastalarda yıllık relaps oranının yüksek olduğu ve kalıcı sakatlığa yol açtığı bildirilmiş (19) . Çalışmamızda, hastanın da ortalama yılda bir atağı olmakla birlikte, halen sekelsiz izlenmektedir.…”

Section: Discussionunclassified

Acquired Demyelinating Syndrome: Single Center Experience

Serin¹,

Şimşek²,

Kanmaz³

et al. 2019

BUCH

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Bu hastalardan birinde hem anti-aquaporin 4 hem de anti-miyelin oligodendrosit antikorları pozitif bulundu. Nörogörüntülemede serebral beyaz cevher, spinal kord ve optik sinir tutulumuyla uyumlu bulgular mevcuttu. Tüm hastalara atak sırasında yüksek doz metilprednizolon tedavisi başlandı ve idame oral steroid ile devam edildi. Relapsları olan hastalarda uzun dönem tedavide azatioprin ve aylık IVIG tedavileri uygulandı. Sonuç: Çocukluk çağı edinsel demiyelinizan hastalıkları multiple sklerozun ilk atağı olabileceğinden hastaların takibi ve ayırıcı tanı için başvuruda ayrıntılı serolojik testlerin, BOS incelemelerinin yapılması önemlidir.

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“…These immune cells have been demonstrated to be involved in the initiation, progression and resolution of multiple sclerosis (MS). In this issue, Yan et al reported a unique group of patients with neu-romyelitis optica spectrum disorder (NMOSD) who carried autoantibodies of aquaporin-4 (AQP4) and myelin-oligodendrocyte glycoprotein (MOG) (Yan et al, 2016). They found NMOSD patients carrying both anti-AQP4 and anti-MOG antibodies exhibited combined features of prototypic NMO and relapsing-remitting form of MS, whereas NMOSD with only anti-MOG antibody exhibited an "intermediate" phenotype between NMOSD and MS, indicating that anti-MOG antibody might be pathogenic in NMOSD patients and that determination of anti-MOG antibody may be instructive for management of NMOSD patients.…”

mentioning

confidence: 99%