2002
DOI: 10.1016/s0304-3894(02)00044-4
|View full text |Cite
|
Sign up to set email alerts
|

Autocatalytic decomposition reactions, hazards and detection

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
24
0

Year Published

2004
2004
2020
2020

Publication Types

Select...
7
3

Relationship

0
10

Authors

Journals

citations
Cited by 50 publications
(25 citation statements)
references
References 2 publications
1
24
0
Order By: Relevance
“…2 for the Fab drug product lots. Such a kinetic profile has been reported for autocatalytic reactions, a mechanism in which at least one of the products acts as a catalyst to further promote the reaction (32)(33)(34)(35).…”
Section: Mechanism and Kinetics Of Trp Oxidation In Fab Drug Product mentioning
confidence: 74%
“…2 for the Fab drug product lots. Such a kinetic profile has been reported for autocatalytic reactions, a mechanism in which at least one of the products acts as a catalyst to further promote the reaction (32)(33)(34)(35).…”
Section: Mechanism and Kinetics Of Trp Oxidation In Fab Drug Product mentioning
confidence: 74%
“…For example, for the isothermal conditions of 130, 145 and 175 • C, 20% conversion was attained after 49, 14 and 1 min, respectively. Such an induction behavior of reaction progress against time is used to confirm the existence of autocatalytic reactions [36,37]. In autocatalytic reactions, the reaction product(s) accelerates the reaction progress with the induction period corresponding to absence of product(s) at the beginning.…”
Section: Thermal Stability Predictionsmentioning
confidence: 99%
“…The heat generation term from a zeroth‐order kinetic expression may then be combined with heat losses to estimate a temperature of no return or an adiabatic time to maximum rate ( TMR ad ) [6,16]. Equation 4 can provide an estimate of the TMR ad as a function of the observed heat rate in the DSC, q̇ at temperature T 0 for nonautocatalytic systems [6,16, 17]: These estimates can serve as an initial quantitative analysis and assist in the decision‐making process with respect to further testing or if changes in process conditions or starting materials need to be explored. Additionally, if the conservative result is not economically feasible or is impractical, then additional testing can be done that will result in more accurate modeling with a higher degree of confidence.…”
Section: Kinetic Modelingmentioning
confidence: 99%