Autochthonous transmission of Leishmania donovani and Leishmania major with all the components of infection cycle at Europe's doorstep

Özbilgin, Ahmet; Tunalı, Varol; Akar, Şebnem Şenol; Yıldırım, Ahmet; Şen, Semra; Çavuş, İbrahim; Zorbozan, Orçun; Gündüz, Cumhur; Turgay, Nevın; İnanır, Işıl

doi:10.1016/j.actatropica.2022.106385

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Notably, there has been a noteworthy shift in the autochthonous transmission of all four species ( L. donovani , L. infantum , L. major , and L. tropica ) responsible for Old World leishmaniasis infections. This was demonstrated in a recent study, which provided evidence of local transmission of these species within the country ( Özbilgin et al, 2022 ).…”

Section: The Evolving Epidemiology Of Leishmaniasis In Turkeymentioning

confidence: 60%

“…Turkey, located at the crossroads of Europe and Asia, has experienced notable changes in the epidemiology of leishmaniasis in recent years, making it a pertinent example for Europe ( Özbilgin et al, 2022 ). Previously considered an endemic region for leishmaniasis, Turkey has witnessed shifts in the disease dynamics, including both geographical expansion and changes in the clinical presentation of cases ( Özbilgin et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Knock, knock, knocking on Europe’s door: Threat of leishmaniasis in Europe with a focus on Turkey

Tunalı,

Özbilgin

2023

Current Research in Parasitology & Vector-Borne Diseases

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Section: The Evolving Epidemiology Of Leishmaniasis In Turkeymentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Knock, knock, knocking on Europe’s door: Threat of leishmaniasis in Europe with a focus on Turkey

Tunalı,

Özbilgin

2023

Current Research in Parasitology & Vector-Borne Diseases

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Visceral Leishmaniasis Caused by Leishmania Tropica

Özbilgin,

Tunalı,

Çavuş

et al. 2023

Acta Parasit.

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The development of L. major, L. donovani and L. martiniquensis, Leishmania currently emerging in Europe, in the sand fly species Phlebotomus perniciosus and P. tobbi

Sadlova,

Hoskova,

Vojtkova

et al. 2024

PLoS Negl Trop Dis

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Background Several new species of Leishmania have recently emerged in Europe, probably as the result of global changes and increased human migration from endemic areas. In this study, we tested whether two sand fly species, the Western Mediterranean Phlebotomus perniciosus and the Eastern Mediterranean P. tobbi, are competent vectors of L. donovani, L. major and L. martiniquensis. Methodology/principal findings Sand flies were infected through the chick skin membrane using Leishmania species and strains of various geographical origins. Leishmania infections were evaluated by light microscopy and qPCR, and the representation of morphological forms was assessed from Giemsa-stained gut smears. Neither P. perniciosus nor P. tobbi supported the development of L. martiniquensis, but L. major and L. donovani in both species survived defecation of blood meal remnants, colonized the stomodeal valve and produced metacyclic stages. The results with L donovani have shown that infection rates in sand flies can be strain-specific; therefore, to determine vector competence or refractoriness, it is optimal to test at least two strains of Leishmania. Conclusions, significance Both sand fly species tested are potential vectors of L. donovani and L. major in Mediterranean area. However, further studies will be needed to identify European vectors of L. martiniquensis and to test the ability of other European sand fly species to transmit L. major, L. donovani, L. tropica and L. infantum.

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Autochthonous transmission of Leishmania donovani and Leishmania major with all the components of infection cycle at Europe's doorstep

Cited by 3 publications

References 20 publications

Knock, knock, knocking on Europe’s door: Threat of leishmaniasis in Europe with a focus on Turkey

Knock, knock, knocking on Europe’s door: Threat of leishmaniasis in Europe with a focus on Turkey

Visceral Leishmaniasis Caused by Leishmania Tropica

The development of L. major, L. donovani and L. martiniquensis, Leishmania currently emerging in Europe, in the sand fly species Phlebotomus perniciosus and P. tobbi

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