Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development

Wang, Yongmei; Bikle, Daniel D.; Chang, Wenhan

doi:10.4248/br201303003

Cited by 67 publications

(55 citation statements)

References 97 publications

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“…Mechanistically, it is believed that IGF‐1−mediated chondrocyte migration occurs primarily through the mitogen‐activated protein kinase and phosphatidylinositol 3‐kinase pathways . These signaling mechanisms are further regulated by parathyroid hormone‐related protein and calcium‐sensing receptor signaling . A limitation of this study is the uncertainty regarding the exact origin of the migrated cells observed in vivo .…”

Section: Discussionmentioning

confidence: 99%

Polymeric mesh and insulin‐like growth factor 1 delivery enhance cell homing and graft−cartilage integration

Boushell

Mosher

Suri

et al. 2019

Annals of the New York Academy of Sciences

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Cartilage injury, such as full‐thickness lesions, predisposes patients to the premature development of osteoarthritis, a degenerative joint disease. While surgical management of cartilage lesions has improved, long‐term clinical efficacy has stagnated, owing to the lack of hyaline cartilage regeneration and inadequate graft−host integration. This study tests the hypothesis that integration of cartilage grafts with native cartilage can be improved by enhancing the migration of chondrocytes across the graft−host interface via the release of chemotactic factor from a degradable polymeric mesh. To this end, a polylactide‐co‐glycolide/poly‐ε‐caprolactone mesh was designed to localize the delivery of insulin‐like growth factor 1 (IGF‐1), a well‐established chondrocyte attractant. The release of IGF‐1 (100 ng/mg) enhanced cell migration from cartilage explants, and the mesh served as critical structural support for cell adhesion, growth, and production of a cartilaginous matrix in vitro, which resulted in increased integration strength compared with mesh‐free repair. Further, this neocartilage matrix was structurally contiguous with native and grafted cartilage when tested in an osteochondral explant model in vivo. These results demonstrate that this combined approach of a cell homing factor and supportive matrix will promote cell‐mediated integrative cartilage repair and improve clinical outcomes of cartilage grafts in the treatment of osteoarthritis.

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Section: Discussionmentioning

confidence: 99%

Polymeric mesh and insulin‐like growth factor 1 delivery enhance cell homing and graft−cartilage integration

Boushell

Mosher

Suri

et al. 2019

Annals of the New York Academy of Sciences

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“…IGF-1 produced by osteoclasts, osteoblasts, and osteocytes acting in an autocrine or paracrine manner also plays an important role in bone remodeling (47). Igf1 transcript levels are increased in bone marrow from colonized mice (Fig.…”

Section: (E and F)mentioning

confidence: 99%

Gut microbiota induce IGF-1 and promote bone formation and growth

Yan

Herzog

Tsang

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

558

531

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Appreciation of the role of the gut microbiome in regulating vertebrate metabolism has exploded recently. However, the effects of gut microbiota on skeletal growth and homeostasis have only recently begun to be explored. Here, we report that colonization of sexually mature germ-free (GF) mice with conventional specific pathogen-free (SPF) gut microbiota increases both bone formation and resorption, with the net effect of colonization varying with the duration of colonization. Although colonization of adult mice acutely reduces bone mass, in long-term colonized mice, an increase in bone formation and growth plate activity predominates, resulting in equalization of bone mass and increased longitudinal and radial bone growth. Serum levels of insulin-like growth factor 1 (IGF-1), a hormone with known actions on skeletal growth, are substantially increased in response to microbial colonization, with significant increases in liver and adipose tissue IGF-1 production. Antibiotic treatment of conventional mice, in contrast, decreases serum IGF-1 and inhibits bone formation. Supplementation of antibiotic-treated mice with short-chain fatty acids (SCFAs), products of microbial metabolism, restores IGF-1 and bone mass to levels seen in nonantibiotic-treated mice. Thus, SCFA production may be one mechanism by which microbiota increase serum IGF-1. Our study demonstrates that gut microbiota provide a net anabolic stimulus to the skeleton, which is likely mediated by IGF-1. Manipulation of the microbiome or its metabolites may afford opportunities to optimize bone health and growth.

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“…These observations led to the hypothesis that GH effects, particularly on growth, were mediated by IGF-1 originating from the liver (Daughaday, 2000). However GH can stimulate IGF-1 expression in other tissues, particularly bone but also skeletal muscle (Brameld et al, 1996;Velloso, 2008: Wang, Bikle & Chang, 2013. In the circulation IGF-1 is associated with…”

Section: Growth Hormonementioning

confidence: 99%

The impact of growth promoters on muscle growth and the potential consequences for meat quality

Parr

Mareko²,

Ryan

et al. 2016

Meat Science

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To meet the demands of increased global meat consumption, animal production systems will have to become more efficient, or at least maintain the current efficiency utilizing feed ingredients that are not also used for human consumption. Use of growth promoters is a potential option for increasing production animal feed efficiency and increased muscle growth. The objective of this manuscript is to describe the mechanisms by which the growth promoters, beta-adrenergic agonists and growth hormone, mediate their effects, with specific consideration of the aspects which have implications for meat quality.

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Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development

Abstract: Insulin-like growth factor-I (IGF-I

Cited by 67 publications

References 97 publications

Polymeric mesh and insulin‐like growth factor 1 delivery enhance cell homing and graft−cartilage integration

Polymeric mesh and insulin‐like growth factor 1 delivery enhance cell homing and graft−cartilage integration

Gut microbiota induce IGF-1 and promote bone formation and growth

The impact of growth promoters on muscle growth and the potential consequences for meat quality

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